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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 3/2020

01.03.2020 | Retinal Disorders

Impact of optical coherence tomography angiography on the non-invasive diagnosis of neovascular age-related macular degeneration

verfasst von: Audrey Giocanti-Auregan, Lise Dubois, Pauline Dourmad, Salomon Y. Cohen

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 3/2020

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Abstract

Purpose

To investigate the changes in imaging tool practice for the diagnosis of neovascular age-related macular degeneration (nAMD).

Methods

Retrospective analysis of consecutive patients diagnosed with nAMD in a tertiary care center, over a 6-month period in 2014, 2016, and 2018. Patient demographics were compared. Imaging modalities used in 2014 were fundus photography, fluorescein angiography (FA), and structural spectral-domain optical coherence tomography (SD-OCT), while OCT-angiography (OCT-A) was available from 2015. Imaging tools used in our practice were compared in the 3 cohorts.

Results

The 3 cohorts included 163, 99, and 167 patients, respectively. There was no difference in age or gender (mean age 81.7 years). OCT-A images were analyzable in 60.5% and 89.7% of patients respectively in 2016 and in 2018. In the 3 cohorts, all patients were imaged with fundus photography and structural OCT. FA was performed in 70.2, 28.8, and 22.1% of patients, respectively.

Conclusion

This study showed a shift in practice of imaging tools used for the diagnosis of nAMD, non-invasive tools being increasingly used as the first-line imaging, and FA as the second-line imaging.
Literatur
1.
Zurück zum Zitat Bressler NM, Bressler SB, Fine SL (1988) Age-related macular degeneration. Surv Ophthalmol 32:375–413CrossRef Bressler NM, Bressler SB, Fine SL (1988) Age-related macular degeneration. Surv Ophthalmol 32:375–413CrossRef
2.
Zurück zum Zitat Soubrane G, Coscas G, Français C, Koenig F (1990) Occult subretinal new vessels in age-related macular degeneration. Natural History and early laser treatment. Ophthalmology 97:649–657CrossRef Soubrane G, Coscas G, Français C, Koenig F (1990) Occult subretinal new vessels in age-related macular degeneration. Natural History and early laser treatment. Ophthalmology 97:649–657CrossRef
3.
Zurück zum Zitat Macular Photocoagulation Study Group (1994) Laser photocoagulation for juxtafoveal choroidal neovascularization. Five year results from randomized clinical trials. Arch Ophthalmol 112:500–509CrossRef Macular Photocoagulation Study Group (1994) Laser photocoagulation for juxtafoveal choroidal neovascularization. Five year results from randomized clinical trials. Arch Ophthalmol 112:500–509CrossRef
4.
Zurück zum Zitat Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Arch Ophthalmol 117:1329–1345CrossRef Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Arch Ophthalmol 117:1329–1345CrossRef
5.
Zurück zum Zitat Puliafito CA, Hee MR, Lin CP, Reichel E, Schuman JS, Duker JS, Izatt JA, Swanson EA, Fujimoto JG (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102:217–229CrossRef Puliafito CA, Hee MR, Lin CP, Reichel E, Schuman JS, Duker JS, Izatt JA, Swanson EA, Fujimoto JG (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102:217–229CrossRef
6.
Zurück zum Zitat Hee MR, Baumal CR, Puliafito CA, Duker JS, Reichel E, Wilkins JR, Coker JG, Schuman JS, Swanson EA, Fujimoto JG (1996) Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology 103:1260–1270CrossRef Hee MR, Baumal CR, Puliafito CA, Duker JS, Reichel E, Wilkins JR, Coker JG, Schuman JS, Swanson EA, Fujimoto JG (1996) Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology 103:1260–1270CrossRef
7.
Zurück zum Zitat Khurana RN, Dupas B, Bressler NM (2010) Agreement of time-domain and spectral-domain optical coherence tomography with fluorescein leakage from choroidal neovascularization. Ophthalmology 117:1376–1380CrossRef Khurana RN, Dupas B, Bressler NM (2010) Agreement of time-domain and spectral-domain optical coherence tomography with fluorescein leakage from choroidal neovascularization. Ophthalmology 117:1376–1380CrossRef
8.
Zurück zum Zitat Ores R, Puche N, Querques G, Blanco-Garavito R, Merle B, Coscas G, Oubraham H, Semoun O, Souied EH (2014) Gray hyper-reflective subretinal exudative lesions in exudative age-related macular degeneration. Am J Ophthalmol 158:354–361CrossRef Ores R, Puche N, Querques G, Blanco-Garavito R, Merle B, Coscas G, Oubraham H, Semoun O, Souied EH (2014) Gray hyper-reflective subretinal exudative lesions in exudative age-related macular degeneration. Am J Ophthalmol 158:354–361CrossRef
9.
Zurück zum Zitat Freund KB, Zweifel SA, Engelbert M (2010) Do we need a new classification for choroidal neovascularization in age-related macular degeneration? Retina 30:1333–1349CrossRef Freund KB, Zweifel SA, Engelbert M (2010) Do we need a new classification for choroidal neovascularization in age-related macular degeneration? Retina 30:1333–1349CrossRef
10.
Zurück zum Zitat Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710–4725CrossRef Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710–4725CrossRef
11.
Zurück zum Zitat Jia Y, Bailey ST, Wilson DJ, Tan O, Klein ML, Flaxel CJ, Potsaid B, Liu JJ, Lu CD, Kraus MF, Fujimoto JG, Huang D (2014) Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology 121:1435–1444CrossRef Jia Y, Bailey ST, Wilson DJ, Tan O, Klein ML, Flaxel CJ, Potsaid B, Liu JJ, Lu CD, Kraus MF, Fujimoto JG, Huang D (2014) Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology 121:1435–1444CrossRef
12.
Zurück zum Zitat de Carlo TE, Bonini Filho MA, Chin AT, Adhi M, Ferrara D, Baumal CR, Witkin AJ, Reichel E, Duker JS, Waheed NK (2015) Spectral-domain optical coherence tomography angiography of choroidal neovascularization. Ophthalmology 122:1228–1238CrossRef de Carlo TE, Bonini Filho MA, Chin AT, Adhi M, Ferrara D, Baumal CR, Witkin AJ, Reichel E, Duker JS, Waheed NK (2015) Spectral-domain optical coherence tomography angiography of choroidal neovascularization. Ophthalmology 122:1228–1238CrossRef
13.
Zurück zum Zitat El Ameen A, Cohen SY, Semoun O, Miere A, Srour M, Quaranta-El Maftouhi M, Oubraham H, Blanco-Garavito R, Querques G, Souied EH (2015) Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography. Retina 35:2212–2218CrossRef El Ameen A, Cohen SY, Semoun O, Miere A, Srour M, Quaranta-El Maftouhi M, Oubraham H, Blanco-Garavito R, Querques G, Souied EH (2015) Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography. Retina 35:2212–2218CrossRef
14.
Zurück zum Zitat Iafe NA, Phasukkijwatana N, Sarraf D (2016) Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration. Dev Ophthalmol 56:45–51CrossRef Iafe NA, Phasukkijwatana N, Sarraf D (2016) Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration. Dev Ophthalmol 56:45–51CrossRef
15.
Zurück zum Zitat Lumbroso B, Rispoli M, Savastano MC (2015) Longitudinal optical coherence tomography-angiography study of type 2 naive choroidal neovascularization early response after treatment. Retina 35:2242–2251CrossRef Lumbroso B, Rispoli M, Savastano MC (2015) Longitudinal optical coherence tomography-angiography study of type 2 naive choroidal neovascularization early response after treatment. Retina 35:2242–2251CrossRef
16.
Zurück zum Zitat Huang D, Jia Y, Rispoli M, Tan O, Lumbroso B (2015) Optical coherence tomography angiography of time course of choroidal neovascularization in response to anti-angiogenic treatment. Retina 35:2260–2264CrossRef Huang D, Jia Y, Rispoli M, Tan O, Lumbroso B (2015) Optical coherence tomography angiography of time course of choroidal neovascularization in response to anti-angiogenic treatment. Retina 35:2260–2264CrossRef
17.
Zurück zum Zitat Rosenfeld PJ (2016) Optical coherence tomography and the development of antiangiogenic therapies in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 57:OCT14–OCT26CrossRef Rosenfeld PJ (2016) Optical coherence tomography and the development of antiangiogenic therapies in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 57:OCT14–OCT26CrossRef
18.
Zurück zum Zitat Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH (2015) Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina 35:2219–2228CrossRef Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH (2015) Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina 35:2219–2228CrossRef
19.
Zurück zum Zitat Kuehlewein L, Sadda SR, Sarraf D (2015) OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy. Eye (Lond) 29:932–935CrossRef Kuehlewein L, Sadda SR, Sarraf D (2015) OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy. Eye (Lond) 29:932–935CrossRef
20.
Zurück zum Zitat Coscas G, Lupidi M, Coscas F, Français C, Cagini C, Souied EH (2015) Optical coherence tomography angiography during follow-up: qualitative and quantitative analysis of mixed type I and II choroidal neovascularization after vascular endothelial growth factor trap therapy. Ophthalmic Res 54:57–63CrossRef Coscas G, Lupidi M, Coscas F, Français C, Cagini C, Souied EH (2015) Optical coherence tomography angiography during follow-up: qualitative and quantitative analysis of mixed type I and II choroidal neovascularization after vascular endothelial growth factor trap therapy. Ophthalmic Res 54:57–63CrossRef
21.
Zurück zum Zitat Cohen SY, Mrejen S (2017) Imaging of exudative age-related macular degeneration: toward a shift in the diagnostic paradigm? Retina 37:1625–1629CrossRef Cohen SY, Mrejen S (2017) Imaging of exudative age-related macular degeneration: toward a shift in the diagnostic paradigm? Retina 37:1625–1629CrossRef
22.
Zurück zum Zitat Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G (2018) Optical coherence tomography angiography. Prog Retin Eye Res 64:1–55CrossRef Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G (2018) Optical coherence tomography angiography. Prog Retin Eye Res 64:1–55CrossRef
23.
Zurück zum Zitat Kuehlewein L, Dansingani KK, de Carlo TE, Bonini Filho MA, Iafe NA, Lenis TL, Freund KB, Waheed NK, Duker JS, Sadda SR, Sarraf D (2015) Optical coherence tomography angiography of type 3 neovascularization secondary to age-related macular degeneration. Retina 35:2229–2235CrossRef Kuehlewein L, Dansingani KK, de Carlo TE, Bonini Filho MA, Iafe NA, Lenis TL, Freund KB, Waheed NK, Duker JS, Sadda SR, Sarraf D (2015) Optical coherence tomography angiography of type 3 neovascularization secondary to age-related macular degeneration. Retina 35:2229–2235CrossRef
24.
Zurück zum Zitat Miere A, Querques G, Semoun O, Amoroso F, Zambrowski O, Chapron T, Capuano V, Souied EH (2017) Optical coherence tomography angiography changes in early type 3 neovascularization after anti-vascular endothelial growth factor treatment. Retina 37:1873–1879CrossRef Miere A, Querques G, Semoun O, Amoroso F, Zambrowski O, Chapron T, Capuano V, Souied EH (2017) Optical coherence tomography angiography changes in early type 3 neovascularization after anti-vascular endothelial growth factor treatment. Retina 37:1873–1879CrossRef
25.
Zurück zum Zitat Tan AC, Dansingani KK, Yannuzzi LA, Sarraf D, Freund KB (2017) Type 3 neovascularization imaged with cross-sectional and en face optical coherence tomography angiography. Retina 37:234–246CrossRef Tan AC, Dansingani KK, Yannuzzi LA, Sarraf D, Freund KB (2017) Type 3 neovascularization imaged with cross-sectional and en face optical coherence tomography angiography. Retina 37:234–246CrossRef
26.
Zurück zum Zitat Mrejen S, Giocanti-Auregan A, Tabary S, Cohen SY (2018) Sensitivity of 840-nm spectral domain optical coherence tomography angiography in detecting type 1 neovascularization according to the height of the associated pigment epithelial detachment. Retina Mrejen S, Giocanti-Auregan A, Tabary S, Cohen SY (2018) Sensitivity of 840-nm spectral domain optical coherence tomography angiography in detecting type 1 neovascularization according to the height of the associated pigment epithelial detachment. Retina
27.
Zurück zum Zitat Yannuzzi LA, Slakter JS, Sorenson JA, Guyer DR, Orlock DA (1992) Digital indocyanine green videoangiography and choroidal neovascularization. Retina 12:191–223CrossRef Yannuzzi LA, Slakter JS, Sorenson JA, Guyer DR, Orlock DA (1992) Digital indocyanine green videoangiography and choroidal neovascularization. Retina 12:191–223CrossRef
28.
Zurück zum Zitat Spaide RF, Fujimoto JG, Waheed NK (2015) Image artifacts in optical coherence tomography angiography. Retina 35:2163–2180CrossRef Spaide RF, Fujimoto JG, Waheed NK (2015) Image artifacts in optical coherence tomography angiography. Retina 35:2163–2180CrossRef
29.
Zurück zum Zitat Hage R, Mrejen S, Krivosic V, Quentel G, Tadayoni R, Gaudric A (2015) Flat irregular retinal pigment epithelium detachments in chronic central serous chorioretinopathy and choroidal neovascularization. Am J Ophthalmol 159:890–903CrossRef Hage R, Mrejen S, Krivosic V, Quentel G, Tadayoni R, Gaudric A (2015) Flat irregular retinal pigment epithelium detachments in chronic central serous chorioretinopathy and choroidal neovascularization. Am J Ophthalmol 159:890–903CrossRef
30.
Zurück zum Zitat Astroz P, Miere A, Mrejen S, Sekfali R, Souied EH, Jung C, Nghiem-Buffet S, Cohen SY (2018) Optical coherence tomography angiography to distinguish choroidal neovascularization from macular inflammatory lesions in multifocal choroiditis. Retina 38:299–309CrossRef Astroz P, Miere A, Mrejen S, Sekfali R, Souied EH, Jung C, Nghiem-Buffet S, Cohen SY (2018) Optical coherence tomography angiography to distinguish choroidal neovascularization from macular inflammatory lesions in multifocal choroiditis. Retina 38:299–309CrossRef
31.
Zurück zum Zitat Yannuzzi LA, Rohrer KT, Tindel LJ, Sobel RS, Costanza MA, Shields W, Zang E (1986) Fluorescein angiography complication survey. Ophthalmology 93:611–617CrossRef Yannuzzi LA, Rohrer KT, Tindel LJ, Sobel RS, Costanza MA, Shields W, Zang E (1986) Fluorescein angiography complication survey. Ophthalmology 93:611–617CrossRef
32.
Zurück zum Zitat Carnevali A, Cicinelli MV, Capuano V, Corvi F, Mazzaferro A, Querques L, Scorcia V, Souied EH, Bandello F, Querques G (2016) Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization. Am J Ophthalmol 169:189–198CrossRef Carnevali A, Cicinelli MV, Capuano V, Corvi F, Mazzaferro A, Querques L, Scorcia V, Souied EH, Bandello F, Querques G (2016) Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization. Am J Ophthalmol 169:189–198CrossRef
33.
Zurück zum Zitat Wolff B, De Bats F, Tick S, Cornut PL, Souied É, Cohen SY (2018) Update from France macula federation: diagnosis of wet AMD. J Fr Ophtalmol 41:857–861CrossRef Wolff B, De Bats F, Tick S, Cornut PL, Souied É, Cohen SY (2018) Update from France macula federation: diagnosis of wet AMD. J Fr Ophtalmol 41:857–861CrossRef
Metadaten
Titel
Impact of optical coherence tomography angiography on the non-invasive diagnosis of neovascular age-related macular degeneration
verfasst von
Audrey Giocanti-Auregan
Lise Dubois
Pauline Dourmad
Salomon Y. Cohen
Publikationsdatum
01.03.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 3/2020
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04581-y

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