Impact of pathologic diagnosis of internal mammary lymph node metastasis in clinical N2b and N3b breast cancer patients
- 07.08.2017
- Clinical trial
Erschienen in:
- Verfasst von
- Ji Hyeon Joo
- Su Ssan Kim
- Seung-Do Ahn
- Eun Kyung Choi
- Jin Hong Jung
- Yuri Jeong
- Sei Hyun Ahn
- Byung Ho Son
- Jong Won Lee
- Hee Jung Kim
- Beom Seok Go
- Hak Hee Kim
- Joo Hee Cha
- Hee Jung Shin
- Eun Young Chae
- Erschienen in
- Breast Cancer Research and Treatment | Ausgabe 2/2017
Abstract
Purpose
To analyze the prognostic role of pathologic confirmation of internal mammary lymph nodes (IMNs) for breast cancer patients who received neoadjuvant chemotherapy.
Methods
Of the patients who were treated with neoadjuvant chemotherapy, surgery, and radiation therapy between 2009 and 2013, 114 women had suspicious IMNs and FNAB was attempted. Clinical IMN metastasis was diagnosed by 18F-FDG PET/CT positivity or pathologic confirmation (N = 70). Patients were divided into the FNAB(+) or FNAB(−) IMN group.
Results
The pathologic confirmation rate was 57% (40 of 70 patients). Rates were 74% in US-positive, 70% in MRI-positive, and 55% in PET-positive patients. Nodal stage was cN2b (6%) or cN3b (94%). Five-year progression-free survival (PFS) was significantly worse in patients with FNAB(+) IMN metastasis than FNAB(−) IMN metastasis (61% vs. 87%, P = 0.03). FNAB(+) IMN patients showed worse distant metastasis and regional recurrence-free survival without statistical significance (69% vs. 86%, P = 0.06, and 81% vs. 96%, P = 0.06). With median follow-up of 50.5 months (13.0–97.0 months), overall survival at 5 years was 77%, and PFS was 72%.
Conclusions
Patients with FNAB-proven IMN metastasis had worse treatment outcomes compared to patients with clinically diagnosed IMN metastasis in cN2b/N3b breast cancer.
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- Titel
- Impact of pathologic diagnosis of internal mammary lymph node metastasis in clinical N2b and N3b breast cancer patients
- Verfasst von
-
Ji Hyeon Joo
Su Ssan Kim
Seung-Do Ahn
Eun Kyung Choi
Jin Hong Jung
Yuri Jeong
Sei Hyun Ahn
Byung Ho Son
Jong Won Lee
Hee Jung Kim
Beom Seok Go
Hak Hee Kim
Joo Hee Cha
Hee Jung Shin
Eun Young Chae
- Publikationsdatum
- 07.08.2017
- Verlag
- Springer US
- Erschienen in
-
Breast Cancer Research and Treatment / Ausgabe 2/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217 - DOI
- https://doi.org/10.1007/s10549-017-4422-2
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