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Erschienen in: Pituitary 2/2022

10.01.2022

Impact of patient-reported nasal symptoms on quality of life after endoscopic pituitary surgery: a prospective cohort study

verfasst von: Merel van der Meulen, Marco J. T. Verstegen, Daniel J. Lobatto, Maarten C. Kleijwegt, Alberto M. Pereira, Nienke R. Biermasz, Wouter R. van Furth, Amir H. Zamanipoor Najafabadi

Erschienen in: Pituitary | Ausgabe 2/2022

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Abstract

Purpose

Endoscopic transsphenoidal surgery causes nasal morbidity and negatively affects health-related quality of life (HRQoL). Knowledge on actionable symptoms that could improve postoperative HRQoL is therefore important. This study assessed the impact of nasal symptoms on postoperative HRQoL.

Methods

This perioperative cohort study included 103 adult patients undergoing endoscopic pituitary adenoma resection (August 2016–December 2018), with measurements preoperatively, and 5 days, 6 weeks and 6 months after surgery. Nasal symptoms were measured with the Anterior Skull base nasal inventory-12, and HRQoL with the Short Form-36 (SF-36) physical (PCS) and mental component scores (MCS). Linear regression analysis was used to assess (1) determinants of postoperative nasal morbidity, (2) associations between number of symptoms or (3) individual symptoms and HRQoL, and (4) the percentage of variance of HRQoL explained by nasal symptoms.

Results

The number of nasal symptoms transiently increased after surgery. No significant treatment- or disease-related determinants of nasal morbidity were identified. The number of nasal symptoms was significantly associated with a lower PCS (β = − 1.0; 95%CI − 1.5, − 0.4), but not with MCS at 6 weeks. Similar results were observed at 6 months. Headaches (42.2%), problems with smell (42.0%), and taste (36.0%) were the most prevalent symptoms, while sense of smell and taste, and nasal discharge showed the strongest associations with HRQoL.

Conclusions

Postoperative nasal symptoms, in particular problems with smell and taste, significantly affect pituitary patients’ physical HRQoL. Monitoring of these symptoms may aid in determining which patients may benefit from intensified follow-up and treatment, aiming to optimize HRQoL.
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Literatur
6.
Zurück zum Zitat Zamanipoor Najafabadi AH, Zandbergen IM, de Vries F, Broersen LHA, van den Akker-van Marle ME, Pereira AM, Peul WC, Dekkers OM, van Furth WR, Biermasz NR (2020) Surgery as a viable alternative first-line treatment for prolactinoma patients. A systematic review and meta-analysis. J Clin Endocrinol Metab 105(3):e32-41. https://​doi.​org/​10.​1210/​clinem/​dgz144 CrossRef Zamanipoor Najafabadi AH, Zandbergen IM, de Vries F, Broersen LHA, van den Akker-van Marle ME, Pereira AM, Peul WC, Dekkers OM, van Furth WR, Biermasz NR (2020) Surgery as a viable alternative first-line treatment for prolactinoma patients. A systematic review and meta-analysis. J Clin Endocrinol Metab 105(3):e32-41. https://​doi.​org/​10.​1210/​clinem/​dgz144 CrossRef
15.
Zurück zum Zitat Lobatto DJ, Zamanipoor Najafabadi AH, de Vries F, Andela CD, van den Hout WB, Pereira AM, Peul WC, Vliet Vlieland TPM, van Furth WR, Biermasz NR (2019) Toward value based health care in pituitary surgery: application of a comprehensive outcome set in perioperative care. Eur J Endocrinol 181(4):375–387. https://​doi.​org/​10.​1530/​eje-19-0344 CrossRefPubMed Lobatto DJ, Zamanipoor Najafabadi AH, de Vries F, Andela CD, van den Hout WB, Pereira AM, Peul WC, Vliet Vlieland TPM, van Furth WR, Biermasz NR (2019) Toward value based health care in pituitary surgery: application of a comprehensive outcome set in perioperative care. Eur J Endocrinol 181(4):375–387. https://​doi.​org/​10.​1530/​eje-19-0344 CrossRefPubMed
17.
Zurück zum Zitat Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483 CrossRefPubMed Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483 CrossRefPubMed
20.
32.
Zurück zum Zitat Little AS, Kelly DF, Milligan J, Griffiths C, Prevedello DM, Carrau RL, Rosseau G, Barkhoudarian G, Jahnke H, Chaloner C, Jelinek KL, Chapple K, White WL (2015) Comparison of sinonasal quality of life and health status in patients undergoing microscopic and endoscopic transsphenoidal surgery for pituitary lesions: a prospective cohort study. J Neurosurg 123(3):799–807. https://​doi.​org/​10.​3171/​2014.​10.​Jns14921 CrossRefPubMed Little AS, Kelly DF, Milligan J, Griffiths C, Prevedello DM, Carrau RL, Rosseau G, Barkhoudarian G, Jahnke H, Chaloner C, Jelinek KL, Chapple K, White WL (2015) Comparison of sinonasal quality of life and health status in patients undergoing microscopic and endoscopic transsphenoidal surgery for pituitary lesions: a prospective cohort study. J Neurosurg 123(3):799–807. https://​doi.​org/​10.​3171/​2014.​10.​Jns14921 CrossRefPubMed
Metadaten
Titel
Impact of patient-reported nasal symptoms on quality of life after endoscopic pituitary surgery: a prospective cohort study
verfasst von
Merel van der Meulen
Marco J. T. Verstegen
Daniel J. Lobatto
Maarten C. Kleijwegt
Alberto M. Pereira
Nienke R. Biermasz
Wouter R. van Furth
Amir H. Zamanipoor Najafabadi
Publikationsdatum
10.01.2022
Verlag
Springer US
Erschienen in
Pituitary / Ausgabe 2/2022
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-021-01199-4

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