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10.01.2022

Impact of patient-reported nasal symptoms on quality of life after endoscopic pituitary surgery: a prospective cohort study

verfasst von: Merel van der Meulen, Marco J. T. Verstegen, Daniel J. Lobatto, Maarten C. Kleijwegt, Alberto M. Pereira, Nienke R. Biermasz, Wouter R. van Furth, Amir H. Zamanipoor Najafabadi

Erschienen in: Pituitary | Ausgabe 2/2022

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Abstract

Purpose

Endoscopic transsphenoidal surgery causes nasal morbidity and negatively affects health-related quality of life (HRQoL). Knowledge on actionable symptoms that could improve postoperative HRQoL is therefore important. This study assessed the impact of nasal symptoms on postoperative HRQoL.

Methods

This perioperative cohort study included 103 adult patients undergoing endoscopic pituitary adenoma resection (August 2016–December 2018), with measurements preoperatively, and 5 days, 6 weeks and 6 months after surgery. Nasal symptoms were measured with the Anterior Skull base nasal inventory-12, and HRQoL with the Short Form-36 (SF-36) physical (PCS) and mental component scores (MCS). Linear regression analysis was used to assess (1) determinants of postoperative nasal morbidity, (2) associations between number of symptoms or (3) individual symptoms and HRQoL, and (4) the percentage of variance of HRQoL explained by nasal symptoms.

Results

The number of nasal symptoms transiently increased after surgery. No significant treatment- or disease-related determinants of nasal morbidity were identified. The number of nasal symptoms was significantly associated with a lower PCS (β = − 1.0; 95%CI − 1.5, − 0.4), but not with MCS at 6 weeks. Similar results were observed at 6 months. Headaches (42.2%), problems with smell (42.0%), and taste (36.0%) were the most prevalent symptoms, while sense of smell and taste, and nasal discharge showed the strongest associations with HRQoL.

Conclusions

Postoperative nasal symptoms, in particular problems with smell and taste, significantly affect pituitary patients’ physical HRQoL. Monitoring of these symptoms may aid in determining which patients may benefit from intensified follow-up and treatment, aiming to optimize HRQoL.

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Titel: Impact of patient-reported nasal symptoms on quality of life after endoscopic pituitary surgery: a prospective cohort study
verfasst von: Merel van der Meulen
Marco J. T. Verstegen
Daniel J. Lobatto
Maarten C. Kleijwegt
Alberto M. Pereira
Nienke R. Biermasz
Wouter R. van Furth
Amir H. Zamanipoor Najafabadi
Publikationsdatum: 10.01.2022
Verlag: Springer US
Erschienen in: Pituitary / Ausgabe 2/2022
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-021-01199-4

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Impact of patient-reported nasal symptoms on quality of life after endoscopic pituitary surgery: a prospective cohort study