nach oben

The International Journal of Cardiovascular Imaging

Erschienen in:

09.11.2019 | Original Paper

Impact of posteromedial papillary muscle infarction on mitral regurgitation during ST-segment elevation myocardial infarction

verfasst von: Gert Klug, Hans-Josef Feistritzer, Sebastian J. Reinstadler, Martin Reindl, Christina Tiller, Magdalena Holzknecht, Agnes Mayr, Silvana Müller, Axel Bauer, Bernhard Metzler

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 3/2020

Einloggen, um Zugang zu erhalten

Abstract

The exact role of papillary muscle infarction (PMI) during the acute phase of acute ST-segment elevation myocardial infarction (STEMI) is not well understood, as existing data on the impact of PMI location is conflicting. We hypothesized that infarction of the posteromedial papillary muscle (PM-PMI) as determined by cardiac magnetic resonance imaging might be associated with an increased incidence of mitral valve regurgitation in the first week after STEMI. 242 patients with first STEMI underwent a late-enhancement (LGE-) cardiac magnetic resonance imaging within a median of 2 (IQR 2–5) days and echocardiography within 3 (IQR 2–5) days after primary angioplasty for the index event. PMI was scored based on short axis slices (AL-PMI: anterolateral PMI, PM-PMI, AL/PM-PMI: AL- and PM-PMI). Patients with PM-PMI had significantly higher odds (OR 2.62, p < 0.01) for the occurrence of mitral regurgitation than patients with no-PMI, AL-PMI or AL/PM-PMI. Furthermore, advanced age, non-anterior infarct location and longer pain-to-balloon time were identified as risk factors for the occurrence of mitral regurgitation. Binary logistic regression analysis revealed that PM-PMI is a predictor of mitral regurgitation independent of infarct location and age (OR 2.229, CI 1.078–4.903, p = 0.031). PM-PMI as determined by cardiac magnetic resonance imaging is an independent predictor of mitral regurgitation in the setting of acute STEMI. Our data might improve our understanding of the dynamic nature of functional mitral regurgitation.

Tanimoto T, Imanishi T, Kitabata H, Nakamura N, Kimura K, Yamano T, Ishibashi K, Komukai K, Ino Y, Takarada S, Kubo T, Hirata K, Mizukoshi M, Tanaka A, Akasaka T (2010) Prevalence and clinical significance of papillary muscle infarction detected by late gadolinium-enhanced magnetic resonance imaging in patients with ST-segment elevation myocardial infarction. Circulation 122(22):2281–2287. https://doi.org/10.1161/CIRCULATIONAHA.109.935338 CrossRefPubMed

Eitel I, Gehmlich D, Amer O, Wohrle J, Kerber S, Lauer B, Pauschinger M, Schwab J, Birkemeyer R, Zimmermann R, Mende M, de Waha S, Desch S, Gutberlet M, Schuler G, Thiele H (2013) Prognostic relevance of papillary muscle infarction in reperfused infarction as visualized by cardiovascular magnetic resonance. Circ Cardiovasc Imaging 6(6):890–898. https://doi.org/10.1161/CIRCIMAGING.113.000411 CrossRefPubMed

Amigoni M, Meris A, Thune JJ, Mangalat D, Skali H, Bourgoun M, Warnica JW, Barvik S, Arnold JM, Velazquez EJ, Van de Werf F, Ghali J, McMurray JJ, Kober L, Pfeffer MA, Solomon SD (2007) Mitral regurgitation in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: prognostic significance and relation to ventricular size and function. Eur Heart J 28(3):326–333. https://doi.org/10.1093/eurheartj/ehl464 CrossRefPubMed

Ennezat PV, Darchis J, Lamblin N, Tricot O, Elkohen M, Aumegeat V, Equine O, Dujardin X, Saadouni H, Le Tourneau T, de Groote P, Bauters C (2008) Left ventricular remodeling is associated with the severity of mitral regurgitation after inaugural anterior myocardial infarction–optimal timing for echocardiographic imaging. Am Heart J 155(5):959–965. https://doi.org/10.1016/j.ahj.2007.12.007 CrossRefPubMed

Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ (2001) Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 103(13):1759–1764CrossRef

Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, Levine RA (2008) Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J Am Coll Cardiol 51(4):476–486. https://doi.org/10.1016/j.jacc.2007.07.093 CrossRefPubMed

Beaudoin J, Levine RA, Guerrero JL, Yosefy C, Sullivan S, Abedat S, Handschumacher MD, Szymanski C, Gilon D, Palmeri NO, Vlahakes GJ, Hajjar RJ, Beeri R (2013) Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair. Circulation 128(11 Suppl 1):S248–S252. https://doi.org/10.1161/CIRCULATIONAHA.112.000124 CrossRefPubMedPubMedCentral

Kumanohoso T, Otsuji Y, Yoshifuku S, Matsukida K, Koriyama C, Kisanuki A, Minagoe S, Levine RA, Tei C (2003) Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: quantitative analysis of left ventricular and mitral valve geometry in 103 patients with prior myocardial infarction. J Thorac Cardiovasc Surg 125(1):135–143. https://doi.org/10.1067/mva.2003.78 CrossRefPubMed

Srichai MB, Grimm RA, Stillman AE, Gillinov AM, Rodriguez LL, Lieber ML, Lara A, Weaver JA, McCarthy PM, White RD (2005) Ischemic mitral regurgitation: impact of the left ventricle and mitral valve in patients with left ventricular systolic dysfunction. Ann Thorac Surg 80(1):170–178. https://doi.org/10.1016/j.athoracsur.2005.01.068 CrossRefPubMed

10.

D’Ancona G, Biondo D, Mamone G, Marrone G, Pirone F, Santise G, Sciacca S, Pilato M (2008) Ischemic mitral valve regurgitation in patients with depressed ventricular function: cardiac geometrical and myocardial perfusion evaluation with magnetic resonance imaging. Eur J Cardiothorac Surg 34(5):964–968. https://doi.org/10.1016/j.ejcts.2008.07.056 CrossRefPubMed

11.

Asgar AW, Mack MJ, Stone GW (2015) Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations. J Am Coll Cardiol 65(12):1231–1248. https://doi.org/10.1016/j.jacc.2015.02.009 CrossRefPubMed

12.

Okayama S, Uemura S, Soeda T, Onoue K, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Fujimoto S, Saito Y (2011) Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction. Int J Cardiol 146(1):73–79. https://doi.org/10.1016/j.ijcard.2010.04.037 CrossRefPubMed

13.

Chinitz JS, Chen D, Goyal P, Wilson S, Islam F, Nguyen T, Wang Y, Hurtado-Rua S, Simprini L, Cham M, Levine RA, Devereux RB, Weinsaft JW (2013) Mitral apparatus assessment by delayed enhancement CMR: relative impact of infarct distribution on mitral regurgitation. JACC Cardiovasc Imaging 6(2):220–234. https://doi.org/10.1016/j.jcmg.2012.08.016 CrossRefPubMedPubMedCentral

14.

Tsakiris AG, Rastelli GC, Amorim Dde S, Titus JL, Wood EH (1970) Effect of experimental papillary muscle damage on mitral valve closure in intact anesthetized dogs. Mayo Clin Proc 45(4):275–285PubMed

15.

Messas E, Guerrero JL, Handschumacher MD, Chow CM, Sullivan S, Schwammenthal E, Levine RA (2001) Paradoxic decrease in ischemic mitral regurgitation with papillary muscle dysfunction: insights from three-dimensional and contrast echocardiography with strain rate measurement. Circulation 104(16):1952–1957CrossRef

16.

Uemura T, Otsuji Y, Nakashiki K, Yoshifuku S, Maki Y, Yu B, Mizukami N, Kuwahara E, Hamasaki S, Biro S, Kisanuki A, Minagoe S, Levine RA, Tei C (2005) Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling: insights from tissue Doppler strain imaging. J Am Coll Cardiol 46(1):113–119. https://doi.org/10.1016/j.jacc.2005.03.049 CrossRefPubMed

17.

Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, Klocke FJ, Bonow RO, Kim RJ, Judd RM (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361(9355):374–379. https://doi.org/10.1016/S0140-6736(03)12389-6 CrossRefPubMed

18.

Bouma W, Willemsen HM, Lexis CP, Prakken NH, Lipsic E, van Veldhuisen DJ, Mariani MA, van der Harst P, van der Horst IC (2016) Chronic ischemic mitral regurgitation and papillary muscle infarction detected by late gadolinium-enhanced cardiac magnetic resonance imaging in patients with ST-segment elevation myocardial infarction. Clin Res Cardiol. https://doi.org/10.1007/s00392-016-1006-9 CrossRefPubMedPubMedCentral

19.

Reinstadler SJ, Klug G, Feistritzer HJ, Kofler M, Pernter B, Gobel G, Henninger B, Muller S, Franz WM, Metzler B (2016) Prognostic value of left ventricular global function index in patients after ST-segment elevation myocardial infarction. Eur Heart J Cardiovasc Imaging 17(2):169–176. https://doi.org/10.1093/ehjci/jev129 CrossRefPubMed

20.

Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Katus HA, Apple FS, Lindahl B, Morrow DA, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Torbicki A, Vahanian A, Windecker S, Morais J, Aguiar C, Almahmeed W, Arnar DO, Barili F, Bloch KD, Bolger AF, Botker HE, Bozkurt B, Bugiardini R, Cannon C, de Lemos J, Eberli FR, Escobar E, Hlatky M, James S, Kern KB, Moliterno DJ, Mueller C, Neskovic AN, Pieske BM, Schulman SP, Storey RF, Taubert KA, Vranckx P, Wagner DR (2012) Third universal definition of myocardial infarction. J Am Coll Cardiol 60(16):1581–1598. https://doi.org/10.1016/j.jacc.2012.08.001 CrossRefPubMed

21.

Feistritzer HJ, Klug G, Reinstadler SJ, Grober MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B (2015) Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI. Open Heart 2(1):e000244. https://doi.org/10.1136/openhrt-2015-000244 CrossRefPubMedPubMedCentral

22.

Reinstadler SJ, Klug G, Feistritzer HJ, Mayr A, Harrasser B, Mair J, Bader K, Streil K, Hammerer-Lercher A, Esterhammer R, Metzler B (2013) Association of copeptin with myocardial infarct size and myocardial function after ST segment elevation myocardial infarction. Heart 99(20):1525–1529. https://doi.org/10.1136/heartjnl-2013-303975 CrossRefPubMed

23.

Veltman CE, van der Hoeven BL, Hoogslag GE, Boden H, Kharbanda RK, de Graaf MA, Delgado V, van Zwet EW, Schalij MJ, Bax JJ, Scholte AJ (2015) Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction. Eur Heart J 36(17):1023–1030. https://doi.org/10.1093/eurheartj/ehu236 CrossRefPubMed

24.

Klug G, Mayr A, Schenk S, Esterhammer R, Schocke M, Nocker M, Jaschke W, Pachinger O, Metzler B (2012) Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 14:46. https://doi.org/10.1186/1532-429X-14-46 CrossRefPubMedPubMedCentral

25.

Klug G, Trieb T, Schocke M, Nocker M, Skalla E, Mayr A, Nowosielski M, Pedarnig K, Bartel T, Moes N, Pachinger O, Metzler B (2009) Quantification of regional functional improvement of infarcted myocardium after primary PTCA by contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 29(2):298–304. https://doi.org/10.1002/jmri.21498 CrossRefPubMed

26.

Lancellotti P, Moura L, Pierard LA, Agricola E, Popescu BA, Tribouilloy C, Hagendorff A, Monin JL, Badano L, Zamorano JL (2010) European Association of Echocardiography recommendations for the assessment of valvular regurgitation Part 2: mitral and tricuspid regurgitation (native valve disease). Eur J Echocardiogr 11(4):307–332. https://doi.org/10.1093/ejechocard/jeq031 CrossRefPubMed

27.

Miller GE Jr, Kerth WJ, Gerbode F (1968) Experimental papillary muscle infarction. J Thorac Cardiovasc Surg 56(5):611–616CrossRef

28.

Bouma W, Lexis CP, Willems TP, Suurmeijer A, van der Horst I, Ebels T, Mariani MA (2011) Successful surgical excision of primary right atrial angiosarcoma. J Cardiothorac Surg 6:47. https://doi.org/10.1186/1749-8090-6-47 CrossRefPubMedPubMedCentral

Titel: Impact of posteromedial papillary muscle infarction on mitral regurgitation during ST-segment elevation myocardial infarction
verfasst von: Gert Klug
Hans-Josef Feistritzer
Sebastian J. Reinstadler
Martin Reindl
Christina Tiller
Magdalena Holzknecht
Agnes Mayr
Silvana Müller
Axel Bauer
Bernhard Metzler
Publikationsdatum: 09.11.2019
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 3/2020
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-019-01726-2

Neu im Fachgebiet Kardiologie

19.04.2024 | Vorhofflimmern | Nachrichten

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Impact of posteromedial papillary muscle infarction on mitral regurgitation during ST-segment elevation myocardial infarction

Abstract

Neu im Fachgebiet Kardiologie

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Kardiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2020

Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

Cardiovascular MRI evidence of reduced systolic function and reduced LV mass in rheumatoid arthritis: impact of disease phenotype

Echocardiographic assessment of residuals after transvenous intracardiac lead extraction

Apical variant hypertrophic cardiomyopathy “multimodality imaging evaluation”

Three dimensional transesophageal echocardiography: a missing link in infective endocarditis imaging?

Combined use of electro-anatomic mapping system and intracardiac echocardiography to achieve zero-fluoroscopy catheter ablation for treatment of paroxysmal atrial fibrillation: a single centre experience

Neu im Fachgebiet Kardiologie

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Kardiologie