Impact of Preoperative Muscle and Fat Indices on Post-Sleeve Gastrectomy Weight Loss
- 13.09.2025
- Research
Erschienen in:
- Verfasst von
- JingHao Xu
- DanLu Liu
- YuTong Chen
- YuJie Pu
- Mulusa Fumpa
- Qiang Du
- QianYi Wan
- Rui Zhao
- GuiXiang Zhang
- Xiao Du
- Zhong Cheng
- Jason Widjaja
- Yi Chen
- Erschienen in
- Obesity Surgery | Ausgabe 10/2025
Abstract
Background
Obesity, a chronic disease characterized by pathological fat accumulation, requires effective therapeutic strategies. While sleeve gastrectomy (SG) demonstrates superior efficacy for sustained weight loss, clinical guidelines lack integration of objective body composition metrics used in chronic disease management. This study aims to investigate the relationship between preoperative body composition and postoperative weight loss outcomes in patients undergoing SG.
Methods
Patients with obesity who underwent SG at our center between October 2019 and May 2024 were enrolled. Preoperative body composition was assessed using abdominal computed tomography (CT) and bioelectrical impedance analysis (BIA). Weight loss outcomes were evaluated using body mass index (BMI), percentage of excess weight loss (%EWL), and percentage of total weight loss (%TWL). Regression and receiver operating characteristic (ROC) analyses were performed to identify predictors of surgical success.
Results
In a study of 315 individuals (63.5% female). CT analysis showed that males had significantly higher core muscle mass, including psoas major index (10.71 ± 2.35 vs. 7.12 ± 1.54 cm2/m2, p < 0.001) and abdominal wall muscle index (58.19 ± 7.51 vs. 46.69 ± 5.83 cm2/m2, p = 0.01), with no significant sex differences in fat distribution. Female patients achieved higher 1-year %EWL than males (1.162 ± 0.491 vs. 1.021 ± 0.513, p < 0.001). Multivariate regression identified age (OR = 0.925, 95% CI 0.861–0.993; p = 0.032), wall muscle area (OR = 0.557, 0.349–0.888; p = 0.014) and wall muscle index (OR = 4.214, 1.226–14.489; p = 0.02) as independent predictors of weight loss. The combined model had better predictive accuracy for percent weight loss than body mass index alone (AUC = 0.840 vs ≤ 0.682; p < 0.001).
Conclusion
Preoperative body composition, particularly core muscle mass and subcutaneous fat distribution, is strongly associated with postoperative weight loss outcomes after SG. CT-based assessments may offer valuable prognostic insight predict surgical outcomes and adjust interventions accordingly.
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- Titel
- Impact of Preoperative Muscle and Fat Indices on Post-Sleeve Gastrectomy Weight Loss
- Verfasst von
-
JingHao Xu
DanLu Liu
YuTong Chen
YuJie Pu
Mulusa Fumpa
Qiang Du
QianYi Wan
Rui Zhao
GuiXiang Zhang
Xiao Du
Zhong Cheng
Jason Widjaja
Yi Chen
- Publikationsdatum
- 13.09.2025
- Verlag
- Springer US
- Erschienen in
-
Obesity Surgery / Ausgabe 10/2025
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428 - DOI
- https://doi.org/10.1007/s11695-025-08089-9
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