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Erschienen in:

29.08.2020 | Original Article

Impact of pretreatment asymptomatic renal dysfunction on clinical course after esophagectomy

verfasst von: Yuki Kirihataya, Kohei Wakatsuki, Sohei Matsumoto, Hiroshi Nakade, Tomohiro Kunishige, Shintaro Miyao, Masayuki Sho

Erschienen in: Surgery Today | Ausgabe 1/2021

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Abstract

Purpose

Recent large-scale clinical studies have shown that preoperative renal insufficiency is associated with an increased risk of postoperative complications after esophagectomy; however, it remains unclear whether asymptomatic renal dysfunction affects the postoperative course after esophagectomy.

Methods

The subjects of this retrospective study were 177 patients who underwent esophagectomy between May, 2009 and December, 2018. Renal function was evaluated based on the pretreatment estimated glomerular filtration rate (eGFR). Patients were divided into two groups according to the eGFR cut-off value of 55 ml/min per 1.73 m2.

Results

There were 17 patients in the low eGFR group and 160 patients in the normal group eGFR group. The rate of severe complications was significantly higher in the low eGFR than in the normal eGFR group. A low eGFR was the only significant complication risk factor identified; however, there were no marked differences in mortality or survival between the low and normal eGFR groups.

Conclusion

Our findings demonstrate that pretreatment asymptomatic renal dysfunction may be a significant risk factor for severe morbidity after esophagectomy.
Literatur
1.
Zurück zum Zitat Yoshida N, Watanabe M, Baba Y, Iwagami S, Ishimoto T, Iwatsuki M, et al. Risk factors for pulmonary complications after esophagectomy for esophageal cancer. Surg Today. 2014;44(3):526–32.PubMedCrossRef Yoshida N, Watanabe M, Baba Y, Iwagami S, Ishimoto T, Iwatsuki M, et al. Risk factors for pulmonary complications after esophagectomy for esophageal cancer. Surg Today. 2014;44(3):526–32.PubMedCrossRef
2.
Zurück zum Zitat Fuchs HF, Harnsberger CR, Broderick RC, Chang DC, Sandler BJ, Jacobsen GR, et al. Mortality after esophagectomy is heavily impacted by center volume : retrospective analysis of the nationwide inpatient sample. Surg Endosc. 2017;31(6):2491–7.PubMedCrossRef Fuchs HF, Harnsberger CR, Broderick RC, Chang DC, Sandler BJ, Jacobsen GR, et al. Mortality after esophagectomy is heavily impacted by center volume : retrospective analysis of the nationwide inpatient sample. Surg Endosc. 2017;31(6):2491–7.PubMedCrossRef
3.
Zurück zum Zitat Kataoka K, Takeuchi H, Igaki H, Ozawa S, Kato K, Ando N, et al. Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: exploratory analysis of JCOG9907. Ann Surg. 2017;265(6):1152–7.PubMedCrossRef Kataoka K, Takeuchi H, Igaki H, Ozawa S, Kato K, Ando N, et al. Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: exploratory analysis of JCOG9907. Ann Surg. 2017;265(6):1152–7.PubMedCrossRef
5.
Zurück zum Zitat Ferguson MK, Durkin AE. Preoperative prediction of the risk of pulmonary complications after esophagectomy for cancer. J Thorac Cardiovasc Surg. 2002;123(4):661–9.PubMedCrossRef Ferguson MK, Durkin AE. Preoperative prediction of the risk of pulmonary complications after esophagectomy for cancer. J Thorac Cardiovasc Surg. 2002;123(4):661–9.PubMedCrossRef
6.
Zurück zum Zitat Tabira Y, Okuma T, Kondo K, Yoshioka M, Mori T, Tanaka M, et al. Does neoadjuvant chemotherapy for carcinoma in the thoracic esophagus increase postoperative morbidity? Jpn J Thorac Cardiovasc Surg. 1999;47(8):361–7.PubMedCrossRef Tabira Y, Okuma T, Kondo K, Yoshioka M, Mori T, Tanaka M, et al. Does neoadjuvant chemotherapy for carcinoma in the thoracic esophagus increase postoperative morbidity? Jpn J Thorac Cardiovasc Surg. 1999;47(8):361–7.PubMedCrossRef
7.
Zurück zum Zitat Raymond DP, Seder CW, Wright CD, Magee MJ, Kosinski AS, Cassivi SD, et al. Predictors of major morbidity or mortality after resection for esophageal cancer : a society of thoracic surgeons general thoracic surgery database risk adjustment model. Ann Thorac Surg. 2016;102(1):207–14.PubMedPubMedCentralCrossRef Raymond DP, Seder CW, Wright CD, Magee MJ, Kosinski AS, Cassivi SD, et al. Predictors of major morbidity or mortality after resection for esophageal cancer : a society of thoracic surgeons general thoracic surgery database risk adjustment model. Ann Thorac Surg. 2016;102(1):207–14.PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Mokart D, Giaoui E, Barbier L, Lambert J, Sannini A, Chow-Chine L, et al. Postoperative sepsis in cancer patients undergoing major elective digestive surgery is associated with increased long-term mortality. J Crit Care. 2016;31(1):48–53.PubMedCrossRef Mokart D, Giaoui E, Barbier L, Lambert J, Sannini A, Chow-Chine L, et al. Postoperative sepsis in cancer patients undergoing major elective digestive surgery is associated with increased long-term mortality. J Crit Care. 2016;31(1):48–53.PubMedCrossRef
9.
Zurück zum Zitat Abe H, ichi MK. Risk factors for maintenance hemodialysis patients undergoing elective and emergency abdominal surgery. Surg Today. 2014;44(10):1906–11.PubMedPubMedCentralCrossRef Abe H, ichi MK. Risk factors for maintenance hemodialysis patients undergoing elective and emergency abdominal surgery. Surg Today. 2014;44(10):1906–11.PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Newman LA, Mittman N, Hunt Z, Alfonso AE. Survival among chronic renal failure patients requiring major abdominal surgery. J Am Coll Surg. 1999;188(3):310–4.PubMedCrossRef Newman LA, Mittman N, Hunt Z, Alfonso AE. Survival among chronic renal failure patients requiring major abdominal surgery. J Am Coll Surg. 1999;188(3):310–4.PubMedCrossRef
11.
Zurück zum Zitat Nakazato T, Nakamura T, Sekiya N, Sawa Y. Preoperative estimated glomerular filtration rate is an independent predictor of late cardiovascular morbidity after mitral valve surgery. Ann Thorac Cardiovasc Surg. 2014;20(5):390–7.PubMedCrossRef Nakazato T, Nakamura T, Sekiya N, Sawa Y. Preoperative estimated glomerular filtration rate is an independent predictor of late cardiovascular morbidity after mitral valve surgery. Ann Thorac Cardiovasc Surg. 2014;20(5):390–7.PubMedCrossRef
12.
Zurück zum Zitat Wang F, Dupuis JY, Nathan H, Williams K. An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function. Chest. 2003;124(5):1852–62.PubMedCrossRef Wang F, Dupuis JY, Nathan H, Williams K. An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function. Chest. 2003;124(5):1852–62.PubMedCrossRef
13.
Zurück zum Zitat Nagai M, Sho M, Akahori T, Tanaka T, Kinoshita S, Nishiofuku H, et al. Impact of preoperative asymptomatic renal dysfunction on clinical course after pancreatoduodenectomy. J Hepatobiliary Pancreat Sci. 2015;22(11):810–8.PubMedCrossRef Nagai M, Sho M, Akahori T, Tanaka T, Kinoshita S, Nishiofuku H, et al. Impact of preoperative asymptomatic renal dysfunction on clinical course after pancreatoduodenectomy. J Hepatobiliary Pancreat Sci. 2015;22(11):810–8.PubMedCrossRef
14.
Zurück zum Zitat Matsumoto S, Takayama T, Wakatsuki K, Tanaka T, Migita K, Nakajima Y. Short-term and long-term outcomes after gastrectomy for gastric cancer in patients with chronic kidney disease. World J Surg. 2014;38(6):1453–60.PubMedCrossRef Matsumoto S, Takayama T, Wakatsuki K, Tanaka T, Migita K, Nakajima Y. Short-term and long-term outcomes after gastrectomy for gastric cancer in patients with chronic kidney disease. World J Surg. 2014;38(6):1453–60.PubMedCrossRef
15.
Zurück zum Zitat Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53(6):982–92.PubMedCrossRef Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53(6):982–92.PubMedCrossRef
16.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.PubMedPubMedCentralCrossRef Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Iii MHS, Lad NL, Fisher SB, Kooby DA, Weber SM, Brinkman A, et al. The effect of preoperative renal insufficiency on postoperative outcomes after major hepatectomy: a multi-institutional analysis of 1170 patients. J Am Coll Surg. 2014;219(5):914–22.CrossRef Iii MHS, Lad NL, Fisher SB, Kooby DA, Weber SM, Brinkman A, et al. The effect of preoperative renal insufficiency on postoperative outcomes after major hepatectomy: a multi-institutional analysis of 1170 patients. J Am Coll Surg. 2014;219(5):914–22.CrossRef
19.
21.
Zurück zum Zitat Viana JL, Kosmadakis GC, Watson EL, Bevington A, Feehally J, Bishop NC, et al. Evidence for anti-inflammatory effects of exercise in CKD. J Am Soc Nephrol. 2014;25(9):2121–30.PubMedPubMedCentralCrossRef Viana JL, Kosmadakis GC, Watson EL, Bevington A, Feehally J, Bishop NC, et al. Evidence for anti-inflammatory effects of exercise in CKD. J Am Soc Nephrol. 2014;25(9):2121–30.PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Uchihara T, Yoshida N, Baba Y, Yagi T, Toihata T, Oda E. Risk factors for pulmonary morbidities after minimally invasive esophagectomy for esophageal cancer. Surg Endosc. 2018;32(6):2852–8.PubMedCrossRef Uchihara T, Yoshida N, Baba Y, Yagi T, Toihata T, Oda E. Risk factors for pulmonary morbidities after minimally invasive esophagectomy for esophageal cancer. Surg Endosc. 2018;32(6):2852–8.PubMedCrossRef
23.
Zurück zum Zitat Ohi M, Toiyama Y, Omura Y, Ichikawa T, Yasuda H, Okugawa Y. Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer. Surg Today. 2019;49(2):176–86.PubMedCrossRef Ohi M, Toiyama Y, Omura Y, Ichikawa T, Yasuda H, Okugawa Y. Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer. Surg Today. 2019;49(2):176–86.PubMedCrossRef
24.
Zurück zum Zitat Takeuchi H, Miyata H, Baba H, Shimada M, Mori M. A risk model for esophagectomy using data of 5354 patients included in a japanese nationwide web-based database. Ann Surg. 2014;260(2):259–66.CrossRefPubMed Takeuchi H, Miyata H, Baba H, Shimada M, Mori M. A risk model for esophagectomy using data of 5354 patients included in a japanese nationwide web-based database. Ann Surg. 2014;260(2):259–66.CrossRefPubMed
25.
Zurück zum Zitat Zingg U, Smithers BM, Gotley DC, Smith G, Aly A, Clough A, et al. Factors associated with postoperative pulmonary morbidity after esophagectomy for cancer. Ann Surg Oncol. 2011;18(5):1460–8.PubMedCrossRef Zingg U, Smithers BM, Gotley DC, Smith G, Aly A, Clough A, et al. Factors associated with postoperative pulmonary morbidity after esophagectomy for cancer. Ann Surg Oncol. 2011;18(5):1460–8.PubMedCrossRef
Metadaten
Titel
Impact of pretreatment asymptomatic renal dysfunction on clinical course after esophagectomy
verfasst von
Yuki Kirihataya
Kohei Wakatsuki
Sohei Matsumoto
Hiroshi Nakade
Tomohiro Kunishige
Shintaro Miyao
Masayuki Sho
Publikationsdatum
29.08.2020
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 1/2021
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-02118-z

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