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Erschienen in: European Archives of Oto-Rhino-Laryngology 3/2012

01.03.2012 | Head and Neck

Impact of radiotherapy on laryngeal intrinsic muscles

verfasst von: Miroslav Tedla, Matúš Valach, Ricardo L. Carrau, Ivan Varga, Milan Profant, Peter Mráz, Peter Weismann

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2012

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Abstract

Ionizing radiation as a cancer therapy is associated with a variety of undesirable side effects. Consequently, radiotherapy can negatively affect neuromuscular function. Clinical observations have identified problems with swallowing and voice function. Our study aims to evaluate the impact of radiotherapy on laryngeal soft tissues using image analysis to quantify its effect on the structure of the vocalis and thyroarytenoid muscles. Case control study, retrospective analysis. We collected total laryngectomy specimens from six patients with persistent or recurrent cancer who had received preoperative radiotherapy (60–66 Gy). The control group consisted of total laryngectomy specimens from six patients who underwent surgery as primary treatment. Sampling of the specimens only included non-cancerous laryngeal tissue. Laryngeal histological slices were evaluated using digital morphometric analysis system. Percentage of fibrosis and density of muscle fibers within the thyroarytenoid muscle were evaluated in both groups. We found no significant quantitative differences in muscle fibrosis (7.92% vs. 7.52%, P > 0.1). Changes were rather qualitative and included changes in the organization of the muscular fibers. A significant reduction in muscle fibers, however, was observed in the samples from irradiated larynges (66.45% vs. 42.03%, P < 0.01). Our analysis suggests that radiotherapy is responsible for a significant reduction in muscle fibers in the thyroarytenoid muscle and that these changes occur during treatment or relatively early after its completion. Loss of muscle mass after irradiation correlates with clinical observations of muscle weakness and decreased function in patients who undergo radiotherapy.
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Metadaten
Titel
Impact of radiotherapy on laryngeal intrinsic muscles
verfasst von
Miroslav Tedla
Matúš Valach
Ricardo L. Carrau
Ivan Varga
Milan Profant
Peter Mráz
Peter Weismann
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2012
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-011-1686-8

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