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13.04.2024 | Original Article

Impact of surgical proximal and distal margins on the recurrence of resectable colon cancer: a single-center observational cohort study

verfasst von: Tetsuro Kawazoe, Satoshi Toyota, Ryota Nakanishi, Hirotada Tajiri, Yoko Zaitsu, Yuichiro Nakashima, Mitsuhiko Ota, Eiji Oki, Tomoharu Yoshizumi

Erschienen in: Surgery Today | Ausgabe 10/2024

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Abstract

Purpose

Few studies have investigated the impact of the surgical proximal and distal margins on colon cancer recurrence. We conducted this study to investigate the effect of resection margins on the prognosis of resectable colon cancer.

Methods

We analyzed data on 1458 patients who underwent colorectal resection in our institute between January, 2004 and March, 2020, including 579 patients with resectable colon cancer. The association between the resection margin and recurrence for each oncological status was assessed and the value of the resection length that influenced recurrence was analyzed.

Results

Patients who had pT4 colon cancer with margins of more than 7 cm had a trend of fewer recurrences and longer relapse-free survival (RFS) than those with colon cancer of other stages (P = 0.033; hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.20–0.89). Multivariate analysis identified a margin of < 7 cm as an independent risk factor for RFS in patients with pT4 colon cancer (P = 0.023; HR, 2.65; 95% CI 1.013–6.17). No correlation was found between resection margins and recurrence, depending on the extent of lymph node metastasis and tumor location.

Conclusion

A resection margin of at least 7 cm should be maintained for patients with pT4 colon cancer.

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Titel: Impact of surgical proximal and distal margins on the recurrence of resectable colon cancer: a single-center observational cohort study
verfasst von: Tetsuro Kawazoe
Satoshi Toyota
Ryota Nakanishi
Hirotada Tajiri
Yoko Zaitsu
Yuichiro Nakashima
Mitsuhiko Ota
Eiji Oki
Tomoharu Yoshizumi
Publikationsdatum: 13.04.2024
Verlag: Springer Nature Singapore
Erschienen in: Surgery Today / Ausgabe 10/2024
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-024-02836-8

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Impact of surgical proximal and distal margins on the recurrence of resectable colon cancer: a single-center observational cohort study