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Erschienen in: International Journal of Colorectal Disease 4/2019

24.01.2019 | Original Article

Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis

verfasst von: Guangwei Sun, Yalun Li, Yangjie Peng, Dapeng Lu, Fuqiang Zhang, Xueyang Cui, Qingyue Zhang, Zhuang Li

Erschienen in: International Journal of Colorectal Disease | Ausgabe 4/2019

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Abstract

Purpose

We aimed to explore whether the preoperative prognostic nutritional index (PNI) could be an indicator of prognostic outcomes in colorectal cancer (CRC) patients.

Methods

A systematic review and meta-analysis was conducted using the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to a high PNI versus a low PNI in CRC patients were included.

Results

A total of 10 studies involving 6372 patients were included in our meta-analysis. Our overall analysis indicated that the low-PNI group had a significantly reduced overall survival (OS) (HR = 1.87, 95% CI = 1.45–2.42, P < 0.01), cancer-specific survival (HR = 1.53, 95% CI = 1.07–2.19, P = 0.02), and disease-free survival (HR = 1.67, 95% CI = 1.23–2.26, P < 0.01) compared with the high-PNI group. Furthermore, our subgroup results indicated that a high PNI could be a significant indicator of improved OS in TNM stage II (HR = 1.93, 95% CI = 1.29–2.90, P < 0.01) and III (HR = 1.71, 95% CI = 1.25–2.34, P < 0.01), and a similar trend in TNM stage I or IV could also be observed though without statistical significance. Regarding postoperative complications, our pooled results indicated that the low-PNI group had a significantly increased incidence of total and severe postoperative complications.

Conclusions

Our findings indicated that CRC patients with a preoperative high PNI had a significantly improved OS. However, almost only Asian CRC patients were included based on current issue.
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Metadaten
Titel
Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis
verfasst von
Guangwei Sun
Yalun Li
Yangjie Peng
Dapeng Lu
Fuqiang Zhang
Xueyang Cui
Qingyue Zhang
Zhuang Li
Publikationsdatum
24.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Colorectal Disease / Ausgabe 4/2019
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-019-03241-1

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