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Erschienen in: Sleep and Breathing 2/2022

12.08.2021 | Psychiatrics • Original Article

Impact of transdermal trigeminal electrical neuromodulation on subjective and objective sleep parameters in patients with insomnia: a pilot study

verfasst von: Yoo Hyun Um, Sheng-Min Wang, Dong Woo Kang, Nak-Young Kim, Hyun Kook Lim

Erschienen in: Sleep and Breathing | Ausgabe 2/2022

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Abstract

Purpose

Transcutaneous trigeminal electrical neuromodulation (TTEN) is a new treatment modality that has a potential to improve sleep through the suppression of noradrenergic activity. This study aimed to explore the changes of subjective and objective sleep parameters after 4-weeks of daily session of transcutaneous trigeminal electrical neuromodulation in a group of patients with insomnia.

Methods

In a group of patients with insomnia, TTEN targeting the ophthalmic division of the trigeminal nerve was utilized to test the effects of transcutaneous trigeminal electrical neuromodulation. Patients went through daily 20-min sessions of TTEN for 4 weeks. Polysomnography parameters, Pittsburgh sleep quality index, insomnia severity index, and Epworth sleepiness scale were obtained pre- and post-intervention. Changes in these parameters were compared and analyzed.

Results

Among 13 patients with insomnia there was a statistically significant reduction in Pittsburgh sleep quality index, insomnia severity index, and Epworth sleepiness scale scores after 4-week daily sessions of TTEN. There were no differences in polysomnography parameters pre- and post-intervention.

Conclusion

This is the first study to demonstrate the effects of TTEN in a group of insomnia patients. TTEN may improve subjective parameters in patients with insomnia. Further replication studies are needed to support this finding.

Trial registration

The data presented in the study are from a study exploring the effect of TTEN on insomnia (www.​clinicaltrials.​gov, registration number: NCT04838067, date of registration: April 8, 2021, “retrospectively registered”)
Literatur
5.
Zurück zum Zitat Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med : JCSM : Off Publ Am Acad Sleep Med 13:307–349. https://doi.org/10.5664/jcsm.6470CrossRef Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med : JCSM : Off Publ Am Acad Sleep Med 13:307–349. https://​doi.​org/​10.​5664/​jcsm.​6470CrossRef
12.
Zurück zum Zitat Frase L, Piosczyk H, Zittel S, Jahn F, Selhausen P, Krone L, Feige B, Mainberger F, Maier JG, Kuhn M, Klöppel S, Normann C, Sterr A, Spiegelhalder K, Riemann D, Nitsche MA, Nissen C (2016) Modulation of total sleep time by transcranial direct current stimulation (tDCS). Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 41:2577–2586. https://doi.org/10.1038/npp.2016.65CrossRef Frase L, Piosczyk H, Zittel S, Jahn F, Selhausen P, Krone L, Feige B, Mainberger F, Maier JG, Kuhn M, Klöppel S, Normann C, Sterr A, Spiegelhalder K, Riemann D, Nitsche MA, Nissen C (2016) Modulation of total sleep time by transcranial direct current stimulation (tDCS). Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 41:2577–2586. https://​doi.​org/​10.​1038/​npp.​2016.​65CrossRef
18.
Zurück zum Zitat Boasso AM, Mortimore H, Silva R, Aven L, Tyler WJ (2016) Transdermal electrical neuromodulation of the trigeminal sensory nuclear complex improves sleep quality and mood. bioRxiv:043901. https://doi.org/10.1101/043901 Boasso AM, Mortimore H, Silva R, Aven L, Tyler WJ (2016) Transdermal electrical neuromodulation of the trigeminal sensory nuclear complex improves sleep quality and mood. bioRxiv:043901. https://​doi.​org/​10.​1101/​043901
23.
Zurück zum Zitat Sohn SI, Kim DH, Lee MY, Cho YWJS (2012) Breathing. Reliab Validity Korean Version Pittsburgh Sleep Qual Index 16:803–812 Sohn SI, Kim DH, Lee MY, Cho YWJS (2012) Breathing. Reliab Validity Korean Version Pittsburgh Sleep Qual Index 16:803–812
32.
Zurück zum Zitat Yamamoto K, Shinba T (2009) Central noradrenergic system in psychiatry. Seishin Shinkeigaku Zasshi 111:741–761PubMed Yamamoto K, Shinba T (2009) Central noradrenergic system in psychiatry. Seishin Shinkeigaku Zasshi 111:741–761PubMed
33.
Zurück zum Zitat Starling AJ, Tepper SJ, Marmura MJ, Shamim EA, Robbins MS, Hindiyeh N, Charles AC, Goadsby PJ, Lipton RB, Silberstein SD, Gelfand AA, Chiacchierini RP, Dodick DW (2018) A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study). Cephalalgia : Int J Headache 38:1038–1048. https://doi.org/10.1177/0333102418762525CrossRefPubMed Starling AJ, Tepper SJ, Marmura MJ, Shamim EA, Robbins MS, Hindiyeh N, Charles AC, Goadsby PJ, Lipton RB, Silberstein SD, Gelfand AA, Chiacchierini RP, Dodick DW (2018) A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study). Cephalalgia : Int J Headache 38:1038–1048. https://​doi.​org/​10.​1177/​0333102418762525​CrossRefPubMed
Metadaten
Titel
Impact of transdermal trigeminal electrical neuromodulation on subjective and objective sleep parameters in patients with insomnia: a pilot study
verfasst von
Yoo Hyun Um
Sheng-Min Wang
Dong Woo Kang
Nak-Young Kim
Hyun Kook Lim
Publikationsdatum
12.08.2021
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 2/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02459-0

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