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08.04.2020 | Original Paper

Impact of ultra-marathon and marathon on biomarkers of myocyte necrosis and cardiac congestion: a prospective observational study

verfasst von: Claudia Wegberger, Maximilian Tscharre, Paul M. Haller, Edita Piackova, Irena Vujasin, Alja Gomiscek, Ioannis Tentzeris, Matthias K. Freynhofer, Bernhard Jäger, Johann Wojta, Kurt Huber

Erschienen in: Clinical Research in Cardiology | Ausgabe 11/2020

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Abstract

Background

An elevation of cardiac biomarkers is observed after intense or long-lasting physical activity. However, a recent meta-analysis has suggested that there might be an inverse relationship between duration of exercise and degree of biomarker elevation. The objective of this observational study was to investigate the impact of ultra-marathon (UM) vs. marathon (M) on biomarkers of myocyte necrosis and hemodynamic stress/congestion.

Methods

Well-trained endurance athletes were recruited to participate in a 130-km UM and a M run. Troponin I (TnI), creatine kinase (CK), N-terminal pro-brain natriuretic peptide (NT-proBNP), mid-regional pro-adrenomedullin (MR-proADM), and copeptin were measured after both events, respectively.

Results

Fifteen athletes (14 males, one female) were included. There was no difference in exercise intensity according to the Borg scale (UM 16 [IQR 15–17], M 16 [IQR 14–17]; p = 0.424). Biomarkers of myocyte necrosis both differed significantly with higher levels of TnI (UM 0.056 ng/L [IQR 0.022–0.104), M 0.028 ng/L [IQR 0.022–0.049]; p = 0.016) and CK (UM 6992 U/l [IQR 2886–23038], M 425 U/l [IQR 327–681]; p = 0.001) after UM compared to M. Also, NT-proBNP (UM 723 ng/L [IQR 378–1152], M 132 ng/L [IQR 64–198]; p = 0.001) and MR-proADM (UM 1.012 nmol/L [IQR 0.753–0.975], M 0.877 nmol/L [IQR 0.550–0.985]; p = 0.023) as markers of myocardial congestion were significantly higher after UM. There was a tendency for elevated copeptin levels after M, but did not reach statistical significance (p = 0.078).

Conclusion

Ultra-marathon is associated with higher levels of biomarkers of myocyte necrosis and cardiac congestion compared to marathon, highlighting the impact of exercise duration on the cardiovascular system.

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Titel: Impact of ultra-marathon and marathon on biomarkers of myocyte necrosis and cardiac congestion: a prospective observational study
verfasst von: Claudia Wegberger
Maximilian Tscharre
Paul M. Haller
Edita Piackova
Irena Vujasin
Alja Gomiscek
Ioannis Tentzeris
Matthias K. Freynhofer
Bernhard Jäger
Johann Wojta
Kurt Huber
Publikationsdatum: 08.04.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 11/2020
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-020-01634-9

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Conclusion

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