Anzeige
Erschienen in:
03.05.2020 | Original Article
Impacts of anemia and transfusion on oncologic outcomes in patients undergoing surgery for colorectal cancer
Erschienen in: International Journal of Colorectal Disease | Ausgabe 7/2020
Einloggen, um Zugang zu erhaltenAbstract
Purpose
This study aimed to evaluate the prevalence of preoperative anemia
and impacts of anemia and transfusion on survival in patients undergoing surgery
for colorectal cancer.
Methods
This study included patients who underwent surgery for primary
colorectal cancer between 2011 and 2012. The influence of preoperative anemia
and postoperative transfusion on recurrence-free survival and overall survival
were retrospectively investigated. Anemia was defined as hemoglobin level
< 13 g/dL in males and < 12 g/dL in females. The primary outcome was the
prevalence of preoperative anemia in patients with colorectal cancer. Secondary
outcomes included preoperative anemia management, postoperative 30-day mortality
and morbidity, tumor recurrence, and overall survival.
Results
Among a total of 1899 patients, 823 patients (43.3%) were anemic
preoperatively, and 264 patients (13.9%) received postoperative transfusions.
Postoperative transfusion was associated with 30-day postoperative complications
(OR = 1.514, 95% CI = 1.020 ~ 2.247) but not preoperative anemia (OR = 1.143,
95% CI, 0.811 ~ 1.611). Preoperative anemia (HR = 1.459, 95% CI = 1.104 ~ 1.929)
and postoperative transfusion (HR = 1.566, 95% CI = 1.089 ~ 2.252) were
significantly associated with worse recurrence-free survival in multivariable
analysis. Preoperative anemia (HR = 1.572, 95% CI = 1.274 ~ 1.940) and
postoperative transfusion (HR = 1.381, 95% CI = 1.076 ~ 1.773) were significant
independent risk factors for worse overall survival.
Conclusions
Preoperative anemia and postoperative transfusion were associated
with worse survival in patients undergoing surgery for colorectal cancer. An
alternative therapy to treat anemia and reduce transfusions should be introduced
to improve oncologic outcomes.