Background
Methods
Study population
Assessment of renal function
Blood sampling and platelet function tests
Pharmacodynamic endpoints
Statistical analysis
Results
Baseline characteristics of the study patients
Transplant group (n = 36) | Control group (n = 126) |
p
| |
---|---|---|---|
Demographic data | |||
Age (years) | 58.3 ± 1.6 | 72.6 ± 1.1 | <0.001 |
Male sex, n (%) | 26 (72 %) | 79 (63 %) | 0.33 |
Cardiovascular risk factors | |||
Diabetes mellitus, n (%) | 14 (39 %) | 73 (58 %) | 0.025 |
Hypertension, n (%) | 33 (92 %) | 108 (86 %) | 0.16 |
Current smoking, n (%) | 14 (39 %) | 60 (48 %) | 0.12 |
Hypercholesterolemia, n (%) | 30 (83 %) | 104 (83 %) | 0.15 |
Body mass index (kg/m2) | 25.2 ± 0.8 | 27.2 ± 0.5 | 0.05 |
Biological data | |||
eGFR (MDRD formula) (mL/min/1.73 m2) | 47.9 ± 3.7 | 39.5 ± 2.9 | 0.15 |
Anemia (Hb <12.5 g/dL), n (%) | 17 (47 %) | 68 (54 %) | 0.47 |
CRP (mg/dL) | 7.6 ± 1.5 | 25.4 ± 4.1 | 0.02 |
Pharmacodynamic results: biological response to clopidogrel
Variable | OR | CI (95 %) |
p
|
---|---|---|---|
Age (years) | 0.98 | 0.96–1.00 | 0.15 |
Sex (male) | 1.63 | 0.85–3.14 | 0.15 |
Diabetes mellitus | 1.54 | 0.80–2.96 | 0.20 |
Body mass index (kg/m2) | 1.08 | 1.01–1.15 | 0.02 |
Hypertension | 1.94 | 0.72–5.26 | 0.19 |
Tobacco | 1.18 | 0.63–2.22 | 0.61 |
Dyslipidemia | 1.93 | 0.83–4.50 | 0.13 |
eGFR (mL/min/1.73 m2) | 0.99 | 0.98–1.00 | 0.09 |
CRP (mg/dL) | 0.99 | 0.97–1.00 | 0.09 |
Kidney transplantation | 2.61 | 1.22–5.55 | 0.01 |
Calcineurin inhibitors use | 3.15 | 1.41–7.02 | 0.005 |
Anti-metabolites use | 1.94 | 0.87–4.31 | 0.11 |
Proton pump inhibitor use | 1.15 | 0.58–2.29 | 0.69 |
Predictors of high on-treatment platelet reactivity
Variable | OR | CI (95 %) |
p
|
---|---|---|---|
Age (years) | 0.99 | 0.96–1.02 | 0.48 |
Sex (male) | 0.54 | 0.26–1.13 | 0.10 |
Body mass index (kg/m2) | 1.71 | 0.74–3.97 | 0.21 |
Hypertension | 1.68 | 0.57–4.98 | 0.35 |
Dyslipidemia | 1.40 | 0.55–3.59 | 0.48 |
eGFR (mL/min/1.73 m2) | 0.99 | 0.98–1.00 | 0.65 |
CRP (mg/dL) | 0.99 | 0.98–1.00 | 0.24 |
Kidney transplantation | 2.64 | 1.03–6.72 | 0.04 |