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Neurological Sciences

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04.01.2021 | Original Article

Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis

verfasst von: Yumiko Harada, Tomohiko Nakamura, Masashi Suzuki, Masamichi Ueda, Masaaki Hirayama, Masahisa Katsuno

Erschienen in: Neurological Sciences | Ausgabe 8/2021

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Abstract

Background

Cognitive dysfunction characterized by executive dysfunction and persistent attention function has been reported in patients with amyotrophic lateral sclerosis (ALS); however, it is unclear if this contributes to the pain processing deficits associated with the disease.

Objective

We clarified the relationship between pain processing and both cognitive function and sensory symptoms in patients with ALS.

Methods

We enrolled 23 patients with ALS and 14 healthy control subjects. We examined pain-related somatosensory evoked potentials (SEPs) using an intra-epidermal needle electrode. We evaluated cognitive function and the clinical characteristics of sensation and analyzed their relationships with pain-related SEPs.

Results

Pain-related SEP amplitudes were significantly lower, while the rate of amplitude attenuation due to habituation or change in attention was significantly greater in patients with ALS than in control subjects. There were no significant differences in pain-related SEP parameters between patients with or without sensory symptoms. Instead, pain-related SEP amplitude and its rate of attenuation were correlated with cognitive dysfunction, particularly with attention domains.

Conclusions

Our results suggest that attention deficit, but not sensory nerve involvement, is a major cause of the alterations in pain-related SEP in patients with ALS.

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Titel: Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis
verfasst von: Yumiko Harada
Tomohiko Nakamura
Masashi Suzuki
Masamichi Ueda
Masaaki Hirayama
Masahisa Katsuno
Publikationsdatum: 04.01.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 8/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-05028-7

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Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis

Abstract

Background

Objective

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Conclusions

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Springer Medizin

Abstract

Background

Objective

Methods

Results

Conclusions

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