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01.12.2011

Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn’s Disease and Ankylosing Spondylitis

verfasst von: Asgar Ergin, Uta Syrbe, Rebecca Scheer, Andreas Thiel, Thomas Adam, Konrad Büssow, Rainer Duchmann, Martin Zeitz, Joachim Sieper

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2011

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Abstract

Background

To clarify the impact of T cell responses towards enteric antigens for chronic intestinal inflammation, we determined T helper 1 reactivity towards conserved Escherichia coli proteins in patients with Crohn’s disease (CD) and healthy individuals and patients with ankylosing spondylitis (AS), who also often show microscopic inflammatory lesions within the gut or even develop overt inflammatory bowel disease.

Methods

We determined the frequency of IFNγ+CD40L+ cells/CD4+ T cells after stimulation of whole blood with pools of E. coli proteins.

Results

The E. coli-specific Th1 response was significantly reduced in CD patients and to a lower extent also in AS patients.

Conclusions

E. coli is a target for polyclonal Th1 responses in healthy individuals. The impairment of these responses in CD and AS patients might be due to recruitment of enterobacteria-specific Th1 cells to the gut or might reflect inadequate priming of adaptive immune response.

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Titel: Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn’s Disease and Ankylosing Spondylitis
verfasst von: Asgar Ergin
Uta Syrbe
Rebecca Scheer
Andreas Thiel
Thomas Adam
Konrad Büssow
Rainer Duchmann
Martin Zeitz
Joachim Sieper
Publikationsdatum: 01.12.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 6/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-011-9575-x

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Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn’s Disease and Ankylosing Spondylitis

Abstract

Background

Methods

Results

Conclusions

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