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25.01.2018 | Original Article

Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity

verfasst von: Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Yusuke Itani, Norihiko Kodama, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2018

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Abstract

Introduction

Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglobin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and hemoglobin parameters in the tibialis anterior decreased following allo-HSCT, and whether these results were associated with declines in exercise capacity.

Methods

We used near-infrared spectroscopy during and following a repeated isometric contraction task at 50% of maximal voluntary contraction in 18 patients before and after allo-HSCT.

Results

The rate of decrease in the muscle oxy-hemoglobin saturation (SmO₂; an index of skeletal muscle oxygenation) was significantly lower after allo-HSCT (P < 0.01). In contrast, total hemoglobin (an index of hemoglobin) was not different after allo-HSCT. Furthermore, SmO₂ during and following exercise was associated with exercise capacity (r = 0.648; P = 0.004 vs. r = 0.632; P = 0.005).

Conclusion

The results of this study reveal that although the peripheral hemoglobin response was not altered by allo-HSCT, skeletal muscle oxygenation was decreased following allo-HSCT. Furthermore, the decrease in skeletal muscle oxygenation was associated with a reduction in exercise capacity.

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Titel: Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity
verfasst von: Tatsushi Wakasugi
Shinichiro Morishita
Katsuji Kaida
Yusuke Itani
Norihiko Kodama
Kazuhiro Ikegame
Hiroyasu Ogawa
Kazuhisa Domen
Publikationsdatum: 25.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 7/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-017-4036-6

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Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity

Abstract

Introduction

Methods

Results

Conclusion

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Abstract

Introduction

Methods

Results

Conclusion

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