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04.06.2020 | Original Communication

Impaired speed-dependent modulation of the gait pattern in multiple sclerosis

verfasst von: David Weller, Linard Filli, Christian Meyer, Lilla Lörincz, Michael Linnebank, Michael Weller, Armin Curt, Björn Zörner

Erschienen in: Journal of Neurology | Ausgabe 10/2020

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Abstract

Background

Walking dysfunction is common in people with multiple sclerosis (MS). Besides walking speed or endurance, one crucial feature of ambulatory function is the ability to adjust the gait pattern according to walking speed which relies on the integrity of spinal motor centres, their reciprocal connections to supraspinal networks and peripheral sensory input.

Objective

To investigate the capacity of people with MS to modify their gait pattern in response to changes in walking speed.

Methods

3D gait analysis during free treadmill walking was performed in 35 people with MS and 20 healthy controls. Twelve kinematic parameters ranging from basic spatiotemporal measures to complex indicators of intralimb coordination were assessed at different absolute and relative walking speeds.

Results

Cadence, double-limb support time, trunk movements and especially measures of intralimb coordination demonstrated significantly less speed-dependent modifications in MS than in controls. These limitations were more prominent in subjects with stronger MS-related impairment (worse outcome in clinical walking tests, higher Expanded Disability Status Scale).

Conclusion

The incapacity to modify specific elements of the walking pattern according to walking speed contributes to gait dysfunction in people with MS limiting activities of daily living. Gait modulation may serve as sensitive marker of walking function in MS.

Trial registration

Clinicaltrials.gov, NCT01576354; first posted April 12, 2012.

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Titel: Impaired speed-dependent modulation of the gait pattern in multiple sclerosis
verfasst von: David Weller
Linard Filli
Christian Meyer
Lilla Lörincz
Michael Linnebank
Michael Weller
Armin Curt
Björn Zörner
Publikationsdatum: 04.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 10/2020
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09965-3

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Impaired speed-dependent modulation of the gait pattern in multiple sclerosis

Abstract

Background

Objective

Methods

Results

Conclusion

Trial registration

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie

Springer Medizin

Abstract

Background

Objective

Methods

Results

Conclusion

Trial registration

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