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Calcified Tissue International
Erschienen in: Calcified Tissue International 1/2016

27.02.2016 | Review

Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis

verfasst von: Gengyang Shen, Hui Ren, Ting Qiu, De Liang, Bo Xie, Zhida Zhang, Zhensong Yao, Zhidong Yang, Xiaobing Jiang

Erschienen in: Calcified Tissue International | Ausgabe 1/2016

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Abstract

Imbalances between bone formation and resorption are the primary cause of osteoporosis. However, currently, a detailed molecular mechanism of osteoporosis is not available. Autophagy is the conserved process characterized by degrading and recycling aggregated proteins, intracellular pathogens, and damaged organelles. MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes, including autophagy, through the posttranscriptional regulation of gene expression. Conversely, autophagy plays a role in the regulation of miRNA homeostasis. Recent advances have revealed that both autophagy and miRNAs are involved in the maintenance of bone homoeostasis, whereas the role of the interaction of miRNAs with autophagy in osteoporosis remains unclear. In this paper, we review previous reports on autophagy, miRNAs, and their interaction in osteoporosis.
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Metadaten
Titel
Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis
verfasst von
Gengyang Shen
Hui Ren
Ting Qiu
De Liang
Bo Xie
Zhida Zhang
Zhensong Yao
Zhidong Yang
Xiaobing Jiang
Publikationsdatum
27.02.2016
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 1/2016
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-016-0122-x

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Associations of Sarcopenic Obesity and Dynapenic Obesity with Bone Mineral Density and Incident Fractures Over 5–10 Years in Community-Dwelling Older Adults

Erratum

Erratum to: Glucocorticoid Suppresses Connexin 43 Expression by Inhibiting the Akt/mTOR Signaling Pathway in Osteoblasts

Original Research

Secreted Frizzled-Related Protein 5 Attenuates High Phosphate-Induced Calcification in Vascular Smooth Muscle Cells by Inhibiting the Wnt/ß-Catenin Pathway

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