Skip to main content
Erschienen in: World Journal of Surgery 9/2018

10.05.2018 | Original Scientific Report

Improved Outcomes of Enhanced Recovery After Surgery (ERAS) Protocol for Radical Cystectomy with Addition of a Multidisciplinary Care Process in a US Comprehensive Cancer Care Center

verfasst von: Sephalie Y. Patel, Rosemarie E. Garcia Getting, Brandon Alford, Karim Hussein, Braydon J. Schaible, David Boulware, Jae K. Lee, Scott M. Gilbert, Julio M. Powsang, Wade J. Sexton, Philippe E. Spiess, Michael A. Poch

Erschienen in: World Journal of Surgery | Ausgabe 9/2018

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Although enhanced recovery after surgery (ERAS) components include both anesthesia and surgical care processes, it is unclear whether a multidisciplinary approach to implementing ERAS care processes improves clinical outcomes. The addition of multidisciplinary care with anesthesiology-related components to an existing ERAS protocol for radical cystectomy at a US comprehensive cancer center provided an opportunity to compare short- and long-term outcomes.

Methods

We retrospectively compared the outcomes of 116 consecutive patients who underwent cystectomy after implementation of a multidisciplinary ERAS protocol with those of a historical control group of 143 consecutive patients who had been treated with a surgical ERAS protocol. Length of stay, return of bowel function, rate of blood transfusion, nausea, pain, and readmission rates were examined.

Results

Implementation of a multidisciplinary ERAS protocol was associated with better postsurgical symptom control, as indicated by lower rates of patient-reported nausea (P < .05). Multivariate Poisson regression analysis showed a decrease in estimated intraoperative transfusions (P ≤ .001) after adjusting for the effects of potential confounding variables. There were no statistically significant differences noted in length of stay, return of bowel function, 30- and 90-day complications, or readmissions.

Conclusion

This is the first study to investigate the effects of adding anesthesia ERAS components to an existing surgical ERAS protocol for radical cystectomy. We found that with the addition of anesthesia-related interventions, there was a decrease in transfusions and nausea.
Literatur
1.
Zurück zum Zitat Wood DL, Brennan MD, Chaudhry R et al (2008) Standardizing care processes to improve quality and safety of patient care in a large academic practice: the Plummer Project of the Department of Medicine, Mayo Clinic. Health Serv Manage Res 21(4):278–280CrossRef Wood DL, Brennan MD, Chaudhry R et al (2008) Standardizing care processes to improve quality and safety of patient care in a large academic practice: the Plummer Project of the Department of Medicine, Mayo Clinic. Health Serv Manage Res 21(4):278–280CrossRef
2.
Zurück zum Zitat Miller TE, Thacker JK, White WD et al (2014) Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol. Anesth Analg 118(5):1052–1061CrossRefPubMed Miller TE, Thacker JK, White WD et al (2014) Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol. Anesth Analg 118(5):1052–1061CrossRefPubMed
3.
Zurück zum Zitat Bai X, Zhang X, Lu F et al (2016) The implementation of an enhanced recovery after surgery (ERAS) program following pancreatic surgery in an academic medical center of China. Pancreatology 16:665–670CrossRefPubMed Bai X, Zhang X, Lu F et al (2016) The implementation of an enhanced recovery after surgery (ERAS) program following pancreatic surgery in an academic medical center of China. Pancreatology 16:665–670CrossRefPubMed
4.
Zurück zum Zitat Morgan KA, Lancaster WP, Walters ML et al (2016) Enhanced recovery after surgery protocols are valuable in pancreas surgery patients. J Am Coll Surg 222(4):658–664CrossRefPubMed Morgan KA, Lancaster WP, Walters ML et al (2016) Enhanced recovery after surgery protocols are valuable in pancreas surgery patients. J Am Coll Surg 222(4):658–664CrossRefPubMed
5.
Zurück zum Zitat Relph S, Bell A, Sivashanmugarajan V, Munro K et al (2014) Cost effectiveness of enhanced recovery after surgery programme for vaginal hysterectomy: a comparison of pre and post-implementation expenditures. Int J Health Plan Manag 29(4):399–406CrossRef Relph S, Bell A, Sivashanmugarajan V, Munro K et al (2014) Cost effectiveness of enhanced recovery after surgery programme for vaginal hysterectomy: a comparison of pre and post-implementation expenditures. Int J Health Plan Manag 29(4):399–406CrossRef
6.
Zurück zum Zitat Coyle MJ, Main B, Hughes C et al (2016) Enhanced recovery after surgery (ERAS) for head and neck oncology patients. Clin Otolaryngol 41(2):118–126CrossRefPubMed Coyle MJ, Main B, Hughes C et al (2016) Enhanced recovery after surgery (ERAS) for head and neck oncology patients. Clin Otolaryngol 41(2):118–126CrossRefPubMed
7.
Zurück zum Zitat Di Rollo D, Mohammed A, Rawlinson A (2015) Enhanced recovery protocols in urological surgery: a systematic review. Can J Urol 22(3):7817–7823PubMed Di Rollo D, Mohammed A, Rawlinson A (2015) Enhanced recovery protocols in urological surgery: a systematic review. Can J Urol 22(3):7817–7823PubMed
8.
Zurück zum Zitat Tyson MD, Chang SS (2016) Enhanced recovery pathways versus standard care after cystectomy: a meta-analysis of the effect on perioperative outcomes. Eur Urol 70:995–1003CrossRefPubMedPubMedCentral Tyson MD, Chang SS (2016) Enhanced recovery pathways versus standard care after cystectomy: a meta-analysis of the effect on perioperative outcomes. Eur Urol 70:995–1003CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Cerantola Y, Valerio M, Persson B et al (2013) Guidelines for perioperative care after radical cystectomy for bladder cancer: enhanced recovery after surgery (ERAS) society recommendations. Clin Nutr 32:879–887CrossRefPubMed Cerantola Y, Valerio M, Persson B et al (2013) Guidelines for perioperative care after radical cystectomy for bladder cancer: enhanced recovery after surgery (ERAS) society recommendations. Clin Nutr 32:879–887CrossRefPubMed
10.
Zurück zum Zitat Ghodoussipour S, Cameron B, Wang C et al (2017) Is compliance to an enhanced recovery protocol after radical cystectomy associated with improved postoperative outcomes? J Urol 197:e1127–e1128CrossRef Ghodoussipour S, Cameron B, Wang C et al (2017) Is compliance to an enhanced recovery protocol after radical cystectomy associated with improved postoperative outcomes? J Urol 197:e1127–e1128CrossRef
11.
Zurück zum Zitat Pillai P, McEleavy Gaughan M et al (2011) A double-blind randomized controlled clinical trial to assess the effect of doppler optimized intraoperative fluid management on outcome following radical cystectomy. J Urol 186:2201–2206CrossRefPubMed Pillai P, McEleavy Gaughan M et al (2011) A double-blind randomized controlled clinical trial to assess the effect of doppler optimized intraoperative fluid management on outcome following radical cystectomy. J Urol 186:2201–2206CrossRefPubMed
12.
Zurück zum Zitat McGee WT (2009) A simple physiologic algorithm for managing hemodynamics using stroke volume and stroke volume variation: physiologic optimization program. J Int Care Med 24:352–360CrossRef McGee WT (2009) A simple physiologic algorithm for managing hemodynamics using stroke volume and stroke volume variation: physiologic optimization program. J Int Care Med 24:352–360CrossRef
13.
Zurück zum Zitat Ramsingh DS, Sanghvi C, Gamboa J et al (2013) Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial. J Clin Monit Comput 27:249–257CrossRefPubMed Ramsingh DS, Sanghvi C, Gamboa J et al (2013) Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial. J Clin Monit Comput 27:249–257CrossRefPubMed
14.
Zurück zum Zitat Lee CT, Chang SS, Kamat AM et al (2014) Alvimopan accelerates gastrointestinal recovery after radical cystectomy: a multicenter randomized placebo-controlled trial. Eur Urol 66:265–272CrossRefPubMed Lee CT, Chang SS, Kamat AM et al (2014) Alvimopan accelerates gastrointestinal recovery after radical cystectomy: a multicenter randomized placebo-controlled trial. Eur Urol 66:265–272CrossRefPubMed
15.
Zurück zum Zitat Grant MC, Lee H, Page AJ et al (2016) The effect of preoperative gabapentin on postoperative nausea and vomiting: a meta-analysis. Anesth Analg 122:976–985CrossRefPubMed Grant MC, Lee H, Page AJ et al (2016) The effect of preoperative gabapentin on postoperative nausea and vomiting: a meta-analysis. Anesth Analg 122:976–985CrossRefPubMed
16.
Zurück zum Zitat Giglio MT, Marucci M, Testini M et al (2009) Goal-directed hemodynamic therapy and gastrointestinal complications in major surgery: a meta-analysis of randomized controlled trials. Br J Anaesth 103:637–646CrossRefPubMed Giglio MT, Marucci M, Testini M et al (2009) Goal-directed hemodynamic therapy and gastrointestinal complications in major surgery: a meta-analysis of randomized controlled trials. Br J Anaesth 103:637–646CrossRefPubMed
18.
Zurück zum Zitat Wuethrich PY, Studer UE, Thalmann GN et al (2014) Intraoperative continuous norepinephrine infusion combined with restrictive deferred hydration significantly reduces the need for blood transfusion in patients undergoing open radical cystectomy: results of a prospective randomized trial. Eur Urol 66(2):352–360CrossRefPubMed Wuethrich PY, Studer UE, Thalmann GN et al (2014) Intraoperative continuous norepinephrine infusion combined with restrictive deferred hydration significantly reduces the need for blood transfusion in patients undergoing open radical cystectomy: results of a prospective randomized trial. Eur Urol 66(2):352–360CrossRefPubMed
19.
Zurück zum Zitat Johnson SC, Smith ZL, Golan S et al (2017) Temporal trends in perioperative morbidity for radical cystectomy using the National Surgical Quality Improvement Program database. Urol Oncol 35(11):659.e13–659.e19CrossRef Johnson SC, Smith ZL, Golan S et al (2017) Temporal trends in perioperative morbidity for radical cystectomy using the National Surgical Quality Improvement Program database. Urol Oncol 35(11):659.e13–659.e19CrossRef
20.
Zurück zum Zitat Stepaniak PS, Heij C, Buise MP et al (2012) Bariatric surgery with operating room teams that stayed fixed during the day: a multicenter study analyzing the effects on patient outcomes, teamwork and safety climate, and procedure duration. Anesth Analg 115:1384–1392CrossRefPubMed Stepaniak PS, Heij C, Buise MP et al (2012) Bariatric surgery with operating room teams that stayed fixed during the day: a multicenter study analyzing the effects on patient outcomes, teamwork and safety climate, and procedure duration. Anesth Analg 115:1384–1392CrossRefPubMed
21.
Zurück zum Zitat Jaeger MT, Siemens DR, Wei X et al (2017) Association between anesthesiology volumes and early and late outcomes after cystectomy for bladder cancer: a population based study. Anesth Analg 125:147–155CrossRefPubMed Jaeger MT, Siemens DR, Wei X et al (2017) Association between anesthesiology volumes and early and late outcomes after cystectomy for bladder cancer: a population based study. Anesth Analg 125:147–155CrossRefPubMed
22.
Zurück zum Zitat Capdevila X, Moulard S, Plasse C et al (2017) Effectiveness of epidural analgesia, continuous surgical site analgesia, and patient-controlled analgesia morphine for postoperative pain management and hyperalgesia, rehabilitation, and health-related quality of life after open nephrectomy: a prospective, randomized, controlled study. Anesth Analg 124:336–345CrossRefPubMed Capdevila X, Moulard S, Plasse C et al (2017) Effectiveness of epidural analgesia, continuous surgical site analgesia, and patient-controlled analgesia morphine for postoperative pain management and hyperalgesia, rehabilitation, and health-related quality of life after open nephrectomy: a prospective, randomized, controlled study. Anesth Analg 124:336–345CrossRefPubMed
23.
Zurück zum Zitat Amr YM, Yousef AA (2010) Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain 26:381–385CrossRefPubMed Amr YM, Yousef AA (2010) Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain 26:381–385CrossRefPubMed
24.
Zurück zum Zitat Solak O, Metin M, Esme H et al (2007) Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur J Cardiothorac Surg 32:9–12CrossRefPubMed Solak O, Metin M, Esme H et al (2007) Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur J Cardiothorac Surg 32:9–12CrossRefPubMed
Metadaten
Titel
Improved Outcomes of Enhanced Recovery After Surgery (ERAS) Protocol for Radical Cystectomy with Addition of a Multidisciplinary Care Process in a US Comprehensive Cancer Care Center
verfasst von
Sephalie Y. Patel
Rosemarie E. Garcia Getting
Brandon Alford
Karim Hussein
Braydon J. Schaible
David Boulware
Jae K. Lee
Scott M. Gilbert
Julio M. Powsang
Wade J. Sexton
Philippe E. Spiess
Michael A. Poch
Publikationsdatum
10.05.2018
Verlag
Springer International Publishing
Erschienen in
World Journal of Surgery / Ausgabe 9/2018
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-018-4665-z

Weitere Artikel der Ausgabe 9/2018

World Journal of Surgery 9/2018 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.