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Magnetic Resonance Materials in Physics, Biology and Medicine

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15.06.2018 | Research Article

Improvement of ¹⁹F MR image uniformity in a mouse model of cellular therapy using inductive coupling

verfasst von: Bu S. Park, Ge Ma, William T. Koch, Sunder S. Rajan, Manuel Mastromanolis, Johnny Lam, Kyung Sung, Brent McCright

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 1/2019

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Abstract

Objective

Improve ¹⁹F magnetic resonance imaging uniformity of perfluorocarbon (PFC)-labeled cells by using a secondary inductive resonator tuned to 287 MHz to enhance the induced radio frequency (RF) magnetic field (B₁) at 7.05 T.

Materials and methods

Following Faraday’s induction law, the sign of induced B₁ made by the secondary resonator can be changed depending on the tuning of the resonator. A secondary resonator located on the opposite side of the phantom of the ¹⁹F surface coil can be shown to enhance or subtract the induced B₁ field, depending upon its tuning.

Results

The numerical simulation results of rotating transmit B₁ magnitude (|B ₁ ⁺ |) and corresponding experimental ¹⁹F images were compared without and with the secondary resonator. With the secondary resonator tuned to 287 MHz, improvements of |B ₁ ⁺ | and ¹⁹F image uniformity were demonstrated. The use of the secondary resonator improved our ability to visualize transplanted cell location non-invasively over a period of 6 weeks.

Conclusion

The secondary resonator tuned to enhance the induced B₁ results in improved image uniformity in a pre-clinical application, enabling cell tracking of PFC-labeled cells with the secondary resonator.

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Titel: Improvement of 19F MR image uniformity in a mouse model of cellular therapy using inductive coupling
verfasst von: Bu S. Park
Ge Ma
William T. Koch
Sunder S. Rajan
Manuel Mastromanolis
Johnny Lam
Kyung Sung
Brent McCright
Publikationsdatum: 15.06.2018
Verlag: Springer International Publishing
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 1/2019
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-018-0693-9

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Improvement of ¹⁹F MR image uniformity in a mouse model of cellular therapy using inductive coupling

Abstract

Objective

Materials and methods

Results

Conclusion

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Springer Medizin

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Objective

Materials and methods

Results

Conclusion

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