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Erschienen in: International Journal of Computer Assisted Radiology and Surgery 2/2020

07.08.2019 | Original Article

Improving realism in patient-specific abdominal ultrasound simulation using CycleGANs

verfasst von: Santiago Vitale, José Ignacio Orlando, Emmanuel Iarussi, Ignacio Larrabide

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 2/2020

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Abstract

Purpose

In this paper, we propose to apply generative adversarial neural networks trained with a cycle consistency loss, or CycleGANs, to improve realism in ultrasound (US) simulation from computed tomography (CT) scans.

Methods

A ray-casting US simulation approach is used to generate intermediate synthetic images from abdominal CT scans. Then, an unpaired set of these synthetic and real US images is used to train CycleGANs with two alternative architectures for the generator, a U-Net and a ResNet. These networks are finally used to translate ray-casting based simulations into more realistic synthetic US images.

Results

Our approach was evaluated both qualitatively and quantitatively. A user study performed by 21 experts in US imaging shows that both networks significantly improve realism with respect to the original ray-casting algorithm (\(p \ll 0.0001\)), with the ResNet model performing better than the U-Net (\(p \ll 0.0001\)).

Conclusion

Applying CycleGANs allows to obtain better synthetic US images of the abdomen. These results can contribute to reduce the gap between artificially generated and real US scans, which might positively impact in applications such as semi-supervised training of machine learning algorithms and low-cost training of medical doctors and radiologists in US image interpretation.
Literatur
1.
Zurück zum Zitat American College of Emergency Physicians (2001) Use of ultrasound imaging by emergency physicians. Ann Emerg Med 38(4):469 American College of Emergency Physicians (2001) Use of ultrasound imaging by emergency physicians. Ann Emerg Med 38(4):469
2.
Zurück zum Zitat Behboodi B, Rivaz H (2019) Ultrasound segmentation using u-net: learning from simulated data and testing on real data. arXiv:1904.11031 Behboodi B, Rivaz H (2019) Ultrasound segmentation using u-net: learning from simulated data and testing on real data. arXiv:​1904.​11031
3.
Zurück zum Zitat Cohen JP, Luck M, Honari S (2018) Distribution matching losses can hallucinate features in medical image translation. arXiv:1805.08841 Cohen JP, Luck M, Honari S (2018) Distribution matching losses can hallucinate features in medical image translation. arXiv:​1805.​08841
4.
Zurück zum Zitat D’Amato JP, Lo Vercio L, Rubí P, Fernández Vera E, Barbuzza R, del Fresno M, Larrabide I (2015) Efficient scatter model for simulation of ultrasound images from computed tomography data. In: 11th International symposium on medical information processing and analysis, vol 9681. International Society for Optics and Photonics, p 968105 D’Amato JP, Lo Vercio L, Rubí P, Fernández Vera E, Barbuzza R, del Fresno M, Larrabide I (2015) Efficient scatter model for simulation of ultrasound images from computed tomography data. In: 11th International symposium on medical information processing and analysis, vol 9681. International Society for Optics and Photonics, p 968105
5.
Zurück zum Zitat De Leeuw JR (2015) jspsych: a JavaScript library for creating behavioral experiments in a web browser. Behav Res Methods 47(1):1–12CrossRef De Leeuw JR (2015) jspsych: a JavaScript library for creating behavioral experiments in a web browser. Behav Res Methods 47(1):1–12CrossRef
6.
Zurück zum Zitat De Luca V, Tschannen M, Székely G, Tanner C (2013) A learning-based approach for fast and robust vessel tracking in long ultrasound sequences. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 518–525 De Luca V, Tschannen M, Székely G, Tanner C (2013) A learning-based approach for fast and robust vessel tracking in long ultrasound sequences. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 518–525
7.
Zurück zum Zitat Dinh VA, Fu JY, Lu S, Chiem A, Fox JC, Blaivas M (2016) Integration of ultrasound in medical education at United States medical schools: a national survey of directors’ experiences. J Ultrasound Med 35(2):413–419CrossRef Dinh VA, Fu JY, Lu S, Chiem A, Fox JC, Blaivas M (2016) Integration of ultrasound in medical education at United States medical schools: a national survey of directors’ experiences. J Ultrasound Med 35(2):413–419CrossRef
8.
Zurück zum Zitat Engelhardt S, De Simone R, Full PM, Karck M, Wolf I (2018) Improving surgical training phantoms by hyperrealism: Deep unpaired image-to-image translation from real surgeries. arXiv:1806.03627 Engelhardt S, De Simone R, Full PM, Karck M, Wolf I (2018) Improving surgical training phantoms by hyperrealism: Deep unpaired image-to-image translation from real surgeries. arXiv:​1806.​03627
9.
Zurück zum Zitat Goodfellow I, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S, Courville A, Bengio Y (2014) Generative adversarial nets. In: Ghahramani Z, Welling M, Cortes C, Lawrence ND, Weinberger KQ (eds) Proceedings of the 27th international conference on neural information processing systems, vol 2. MIT Press, Cambridge, pp 2672–2680 Goodfellow I, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S, Courville A, Bengio Y (2014) Generative adversarial nets. In: Ghahramani Z, Welling M, Cortes C, Lawrence ND, Weinberger KQ (eds) Proceedings of the 27th international conference on neural information processing systems, vol 2. MIT Press, Cambridge, pp 2672–2680
10.
Zurück zum Zitat He K, Zhang X, Ren S, Sun J (2016) Deep residual learning for image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 770–778 He K, Zhang X, Ren S, Sun J (2016) Deep residual learning for image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 770–778
11.
Zurück zum Zitat Heer I, Middendorf K, Müller-Egloff S, Dugas M, Strauss A (2004) Ultrasound training: the virtual patient. Ultrasound Obstet Gynecol 24(4):440–444CrossRef Heer I, Middendorf K, Müller-Egloff S, Dugas M, Strauss A (2004) Ultrasound training: the virtual patient. Ultrasound Obstet Gynecol 24(4):440–444CrossRef
12.
Zurück zum Zitat Hiasa Y, Otake Y, Takao M, Matsuoka T, Takashima K, Carass A, Prince JL, Sugano N, Sato Y (2018) Cross-modality image synthesis from unpaired data using CycleGAN. In: International workshop on simulation and synthesis in medical imaging. Springer, pp 31–41 Hiasa Y, Otake Y, Takao M, Matsuoka T, Takashima K, Carass A, Prince JL, Sugano N, Sato Y (2018) Cross-modality image synthesis from unpaired data using CycleGAN. In: International workshop on simulation and synthesis in medical imaging. Springer, pp 31–41
14.
Zurück zum Zitat Isola P, Zhu JY, Zhou T, Efros AA (2017) Image-to-image translation with conditional adversarial networks. In: CVPR Isola P, Zhu JY, Zhou T, Efros AA (2017) Image-to-image translation with conditional adversarial networks. In: CVPR
15.
Zurück zum Zitat Kutter O, Shams R, Navab N (2009) Visualization and GPU-accelerated simulation of medical ultrasound from CT images. Comput Methods Progr Biomed 94(3):250–266CrossRef Kutter O, Shams R, Navab N (2009) Visualization and GPU-accelerated simulation of medical ultrasound from CT images. Comput Methods Progr Biomed 94(3):250–266CrossRef
16.
Zurück zum Zitat Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, Van Der Laak JA, Van Ginneken B, Sánchez CI (2017) A survey on deep learning in medical image analysis. Med Image Anal 42:60–88CrossRef Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, Van Der Laak JA, Van Ginneken B, Sánchez CI (2017) A survey on deep learning in medical image analysis. Med Image Anal 42:60–88CrossRef
18.
Zurück zum Zitat Odena A, Dumoulin V, Olah C (2016) Deconvolution and checkerboard artifacts. Distill 1(10):e3CrossRef Odena A, Dumoulin V, Olah C (2016) Deconvolution and checkerboard artifacts. Distill 1(10):e3CrossRef
19.
Zurück zum Zitat Østergaard ML, Ewertsen C, Konge L, Albrecht-Beste E, Nielsen MB (2016) Simulation-based abdominal ultrasound training—a systematic review. Ultraschall in der Medizin Eur J Ultrasound 37(03):253–261CrossRef Østergaard ML, Ewertsen C, Konge L, Albrecht-Beste E, Nielsen MB (2016) Simulation-based abdominal ultrasound training—a systematic review. Ultraschall in der Medizin Eur J Ultrasound 37(03):253–261CrossRef
20.
Zurück zum Zitat Petrusca L, Cattin P, De Luca V, Preiswerk F, Celicanin Z, Auboiroux V, Viallon M, Arnold P, Santini F, Terraz S, Scheffler K, Becker CD, Salomir R (2013) Hybrid ultrasound/magnetic resonance simultaneous acquisition and image fusion for motion monitoring in the upper abdomen. Investig Radiol 48(5):333–340CrossRef Petrusca L, Cattin P, De Luca V, Preiswerk F, Celicanin Z, Auboiroux V, Viallon M, Arnold P, Santini F, Terraz S, Scheffler K, Becker CD, Salomir R (2013) Hybrid ultrasound/magnetic resonance simultaneous acquisition and image fusion for motion monitoring in the upper abdomen. Investig Radiol 48(5):333–340CrossRef
22.
Zurück zum Zitat Ronneberger O, Fischer P, Brox T (2015) U-net: convolutional networks for biomedical image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 234–241 Ronneberger O, Fischer P, Brox T (2015) U-net: convolutional networks for biomedical image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 234–241
23.
Zurück zum Zitat Rubi P, Vera EF, Larrabide I, Calvo M, D’Amato J, Larrabide I (2017) Comparison of real-time ultrasound simulation models using abdominal CT images. In: 12th international symposium on medical information processing and analysis, vol 10160. International Society for Optics and Photonics, p 1016009 Rubi P, Vera EF, Larrabide I, Calvo M, D’Amato J, Larrabide I (2017) Comparison of real-time ultrasound simulation models using abdominal CT images. In: 12th international symposium on medical information processing and analysis, vol 10160. International Society for Optics and Photonics, p 1016009
24.
Zurück zum Zitat Shams R, Hartley R, Navab N (2008) Real-time simulation of medical ultrasound from ct images. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 734–741 Shams R, Hartley R, Navab N (2008) Real-time simulation of medical ultrasound from ct images. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 734–741
25.
Zurück zum Zitat Taigman Y, Polyak A, Wolf L (2017) Unsupervised cross-domain image generation. In: International conference on learning representations, ICLR 2017 Taigman Y, Polyak A, Wolf L (2017) Unsupervised cross-domain image generation. In: International conference on learning representations, ICLR 2017
26.
Zurück zum Zitat Terkamp C, Kirchner G, Wedemeyer J, Dettmer A, Kielstein J, Reindell H, Bleck J, Manns M, Gebel M (2003) Simulation of abdomen sonography. evaluation of a new ultrasound simulator. Ultraschall in der Medizin 24(04):239–244CrossRef Terkamp C, Kirchner G, Wedemeyer J, Dettmer A, Kielstein J, Reindell H, Bleck J, Manns M, Gebel M (2003) Simulation of abdomen sonography. evaluation of a new ultrasound simulator. Ultraschall in der Medizin 24(04):239–244CrossRef
27.
Zurück zum Zitat Walcher F, Weinlich M, Conrad G, Schweigkofler U, Breitkreutz R, Kirschning T, Marzi I (2006) Prehospital ultrasound imaging improves management of abdominal trauma. Br J Surg Inc Eur J Surg Swiss Surg 93(2):238–242 Walcher F, Weinlich M, Conrad G, Schweigkofler U, Breitkreutz R, Kirschning T, Marzi I (2006) Prehospital ultrasound imaging improves management of abdominal trauma. Br J Surg Inc Eur J Surg Swiss Surg 93(2):238–242
28.
Zurück zum Zitat Wang C, Macnaught G, Papanastasiou G, MacGillivray T, Newby D (2018) Unsupervised learning for cross-domain medical image synthesis using deformation invariant cycle consistency networks. In: International workshop on simulation and synthesis in medical imaging. Springer, pp 52–60 Wang C, Macnaught G, Papanastasiou G, MacGillivray T, Newby D (2018) Unsupervised learning for cross-domain medical image synthesis using deformation invariant cycle consistency networks. In: International workshop on simulation and synthesis in medical imaging. Springer, pp 52–60
30.
Zurück zum Zitat Zhu JY, Park T, Isola P, Efros AA (2017) Unpaired image-to-image translation using cycle-consistent adversarial networks. In: ICCV Zhu JY, Park T, Isola P, Efros AA (2017) Unpaired image-to-image translation using cycle-consistent adversarial networks. In: ICCV
Metadaten
Titel
Improving realism in patient-specific abdominal ultrasound simulation using CycleGANs
verfasst von
Santiago Vitale
José Ignacio Orlando
Emmanuel Iarussi
Ignacio Larrabide
Publikationsdatum
07.08.2019
Verlag
Springer International Publishing
Erschienen in
International Journal of Computer Assisted Radiology and Surgery / Ausgabe 2/2020
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI
https://doi.org/10.1007/s11548-019-02046-5

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