Central venous catheter (CVC) placement is one of the most common procedures performed in patients today. Despite measures to improve the safety of this procedure such as use of ultrasound guidance, CVC placement is still associated with a significant risk of complications [
1]. In particular, malpositioned CVCs are associated with an increased risk of vascular complications and catheter malfunction [
2]. Currently, there is no well-accepted strategy for ensuring correct catheter tip positioning. Thus, Mo and colleagues are to be complimented on their data-driven derivation of a formula to improve CVC catheter placement [
3]. …