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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

In-hospital death in acute coronary syndrome was related to admission glucose in men but not in women

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Julio Yoshio Takada, Rogério Bicudo Ramos, Larissa Cardoso Roza, Solange Desiree Avakian, José Antonio Franchini Ramires, Antonio de Pádua Mansur
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-47) contains supplementary material, which is available to authorized users.

Competing interests

Conflicts of Interest and Source of Funding: Authors declare no conflicts of interest. This study was partially supported by FAPESP and CNPq.

Authors’ contribution

JYT cared out paper conception, writing, data collection and statistical analysis. RBR, LCR, SDA participated in data collection. JAFR participated in data analysis and review process. APM carried out paper conception, data collection and analysis. All authors read and approved the final manuscript.

Abstract

Background

Admission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk factors, gender, hyperglycaemia and their effect on hospital mortality.

Methods

959 ACS patients (363 women and 596 men) were grouped based on glycaemia ≥ or < 200 mg/dL and gender: men with glucose < 200 mg/dL (menG-); women with glucose < 200 mg/dL (womenG-); men with glucose ≥ 200 mg/dL (menG+); and women with glucose ≥ 200 mg/dL (womenG+). A logistic regression analysis compared the relation between gender and glycaemia groups and death, adjusted for coronary risk factors and laboratory data.

Results group

menG- had lower mortality than menG + (OR = 0.172, IC95% 0.062-0.478), and womenG + (OR = 0.275, IC95% 0.090-0.841); womenG- mortality was lower than menG + (OR = 0.230, IC95% 0.074-0.717). No difference was found between menG + vs womenG + (p = 0.461), or womenG- vs womenG + (p = 0.110). Age (OR = 1.067, IC95% 1.031–1.104), EF (OR = 0.942, IC95% 0.915-0.968), and serum creatinine (OR = 1.329, IC95% 1.128-1.566) were other independent factors related to in-hospital death.

Conclusions

Death was greater in hyperglycemic men compared to lower blood glucose men and women groups, but there was no differences between women groups in respect to glycaemia after adjustment for coronary risk factors.
Zusatzmaterial
Authors’ original file for figure 1
12933_2012_459_MOESM1_ESM.gif
Authors’ original file for figure 2
12933_2012_459_MOESM2_ESM.gif
Literatur
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