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- 01.06.2025
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- Virchows Archiv | Ausgabe 6/2025
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Sejben et al. (https://doi.org/10.1007/s00428-024-03954-x) studied the presence of gastric-like (pseudopyloric and pseudofoveolar) metaplasia and Paneth cell hyperplasia in ileal biopsies from patients with Crohn’s disease, ulcerative colitis with endoscopically normal ileum or with backwash ileitis, and nonsteroidal anti-inflammatory drugs– (NSAIDs-) induced ileitis. The authors found that pseudofoveolar metaplasia, pseudopyloric metaplasia, and Paneth cell hyperplasia are not uncommon in chronic ileal inflammation. They are most frequently detected in Crohn’s disease but may also be present in NSAID-induced ileitis, whereas they are significantly less common in backwash ileitis and absent in normal ileum. The authors conclude that due to the surface localization of pseudofoveolar metaplasia, its identification can be particularly helpful when dealing with poorly oriented or superficial samples. …
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- In this issue
- Publikationsdatum
- 01.06.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
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Virchows Archiv / Ausgabe 6/2025
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307 - DOI
- https://doi.org/10.1007/s00428-025-04146-x