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17.05.2016 | Original Article | Ausgabe 6/2016

Lasers in Medical Science 6/2016

In vitro and in vivo brain-targeting chemo-photothermal therapy using graphene oxide conjugated with transferrin for Gliomas

Zeitschrift:
Lasers in Medical Science > Ausgabe 6/2016
Autoren:
Haixin Dong, Mei Jin, Zhiming Liu, Honglian Xiong, Xuejun Qiu, Wen Zhang, Zhouyi Guo
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10103-016-1955-2) contains supplementary material, which is available to authorized users.

Abstract

Current therapies for treating malignant glioma exhibit low therapeutic efficiency because of strong systemic side effects and poor transport across the blood brain barrier (BBB). Herein, we combined targeted chemo-photothermal glioma therapy with a novel multifunctional drug delivery system to overcome these issues. Drug carrier transferrin-conjugated PEGylated nanoscale graphene oxide (TPG) was successfully synthesized and characterized. When loaded on the proposed TPG-based drug delivery (TPGD) system, the anticancer drug doxorubicin could pass through the BBB and improve drug accumulation both in vitro and in vivo. TPGD was found to perform dual functions in chemotherapy and photothermal therapy. Targeted TPGD combination therapy showed higher rates of glioma cell death and prolonged survival of glioma-bearing rats compared with single doxorubicin or PGD therapy. In conclusion, we developed a potential nanoscale drug delivery system for combined therapy of glioma that can effectively decrease side effects and improve therapeutic effects.

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