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Erschienen in:
06.09.2019 | Original Article
In vitro evaluation of radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) with static imaging and flow model
Erschienen in: Japanese Journal of Radiology | Ausgabe 10/2019
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Purpose
To evaluate the radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) under X-ray imaging.
Materials and methods
SAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed. The diameter of contrast-loaded SAP-MS in saline was measured sequentially. Radiography of the contrast-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio and visibility by multiple reader scoring. Under digital subtraction angiography, contrast-loaded SAP-MS were injected into a flow model. The flow speed was 1–10 cm/s, and images were acquired at 1–7.5 frames per second using a pulse width of 10–85 ms. Images were assessed by multiple reader scoring.
Results
The diameter of SAP-MS increased to 4.0–5.0 times its original size for approximately 15 min. The diameter of contrast-loaded SAP-MS in saline further increased by 10–30% within several minutes and returned to the previous size. Radiopacity and visibility of contrast-loaded SAP-MS decreased in 30 min after mixing with saline. Visibility was better with slow flow speed and narrow pulse width.
Conclusion
For effective observation, contrast-loaded SAP-MS should be kept in non-diluted contrast material until use. The conditions of slower flow and use of a narrow pulse width are recommended.