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Erschienen in: Inflammation 2/2016

27.02.2016 | ORIGINAL ARTICLE

In Vitro Oxidation of Collagen Promotes the Formation of Advanced Oxidation Protein Products and the Activation of Human Neutrophils

verfasst von: Guilherme Vargas Bochi, Vanessa Dorneles Torbitz, Luízi Prestes de Campos, Manuela Borges Sangoi, Natieli Flores Fernandes, Patrícia Gomes, Maria Beatriz Moretto, Fernanda Barbisan, Ivana Beatrice Mânica da Cruz, Rafael Noal Moresco

Erschienen in: Inflammation | Ausgabe 2/2016

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Abstract

The accumulation of advanced oxidation protein products (AOPPs) has been linked to several pathological conditions. Here, we investigated collagen as a potential source for AOPP formation and determined the effects of hypochlorous acid (HOCl)-treated collagen (collagen-AOPPs) on human neutrophil activity. We also assessed whether alpha-tocopherol could counteract these effects. Exposure to HOCl increased the levels of collagen-AOPPs. Collagen-AOPPs also stimulated the production of AOPPs, nitric oxide (NO), superoxide radicals (O2 ), and HOCl by neutrophils. Collagen-AOPPs induced apoptosis and decreased the number of viable cells. Alpha-tocopherol prevented the formation of collagen-AOPPs, strongly inhibited the collagen-AOPP-induced production of O2 and HOCl, and increased the viability of neutrophils. Our results suggest that collagen is an important protein that interacts with HOCl to form AOPPs, and consequently, collagen-AOPP formation is related to human neutrophil activation and cell death.
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Metadaten
Titel
In Vitro Oxidation of Collagen Promotes the Formation of Advanced Oxidation Protein Products and the Activation of Human Neutrophils
verfasst von
Guilherme Vargas Bochi
Vanessa Dorneles Torbitz
Luízi Prestes de Campos
Manuela Borges Sangoi
Natieli Flores Fernandes
Patrícia Gomes
Maria Beatriz Moretto
Fernanda Barbisan
Ivana Beatrice Mânica da Cruz
Rafael Noal Moresco
Publikationsdatum
27.02.2016
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 2/2016
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-016-0325-3

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