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05.08.2023 | Original Article

In vivo efficacy of silver nanoparticles against Syphacia muris infected laboratory Wistar rats

verfasst von: Mona Fathi Fol, Salwa Abdel-Hamid Hamdi, Heba Ali Abdel-Rahman, Nesma Abbas Mostafa

Erschienen in: Journal of Parasitic Diseases | Ausgabe 4/2023

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Abstract

Helminth infections are a worldwide problem that affects both humans and animals in developing countries. The common pinworm Syphacia muris frequently infects lab rats and can obstruct the creation of unrelated biological experiments. The objective of this study was to examine the in vivo efficacy of silver nanoparticles against S. muris infected Wistar rats. Transmission electron microscopy and X-ray diffraction examinations of silver nanoparticles revealed highly pure polycrystals with a mean size of 4 nm. Rats were divided into group I, the control: received distilled water; groups II and III, the treated: received 2, 4 mg/kg b.w. of Ag NPs, respectively. At the end of the experimental period, all rats were euthanized and dissected for collecting worms. The surface topography of the recovered worms was displayed using light and scanning electron microscopy, and their physiological status was determined using oxidative stress biomarkers. The histological changes in the rat liver, kidney, and spleen were also examined. In the current study, Ag NPs administration revealed substantial alterations in worms collected from treated rats, including shrinkage of lips, peeling and rupture of body cuticles, and disruption of surface annulations. Also, induced a significant increase in malondialdehyde and nitric oxide levels, as well as a decrease in reduced glutathione, glutathione peroxidase and catalase levels compared to control group. Moreover, sections of treated rats' liver, kidney and spleen displayed normal cellular appearance. In conclusion, this is the first in vivo study to evaluate Ag NPs efficacy against S. muris in laboratory rats without significant toxicity.

Adefegha SA, Dada FA, Oyeleye SI, Oboh G (2022) Effect of oral berberine administration on the renal profiles of adenosine deaminase, arginase, and nitric oxide in streptozotocin-induced diabetic nephropathy of rats. Comp Clin Path 31:255–263. https://doi.org/10.1007/s00580-022-03329-1CrossRef

Aderibigbe BA (2017) Metal-based nanoparticles for the treatment of infectious diseases. Molecules 22(1370):1–37. https://doi.org/10.3390/molecules22081370CrossRef

Adeyemi OS, Whiteley CG (2013) Interaction of nanoparticles with arginine kinase from Trypanosoma brucei: kinetic and mechanistic evaluation. Int J Biol Macromol 62:450–456. https://doi.org/10.1016/j.ijbiomac.2013.09.008CrossRefPubMed

Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ (2010) Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 242(3):263–269. https://doi.org/10.1016/j.taap.2009.10.016CrossRefPubMed

Ali D, Alarifi S, Kumar S, Ahmed M, Siddiqui MA (2012) Oxidative stress and genotoxic effect of zinc oxide nanoparticles in freshwater snail Lymnaea luteola L. Aquat Toxicol 124(125):83–90. https://doi.org/10.1016/j.aquatox.2012.07.012CrossRefPubMed

Ali M, Afzal M, Verma M, Bhattacharya SM et al (2014) Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. Parasitol Res 113:681–691. https://doi.org/10.1007/s00436-013-3696-5CrossRefPubMed

Ali R, Ahmad N, Mussarat S, Majid A, Alnomasy SF, Khan SN (2021) Nanoparticles as alternatives for the control of Haemonchus contortus: a systematic approach to unveil new anti-haemonchiasis agents. Front Vet Sci 8:789977. https://doi.org/10.3389/fvets.2021.789977CrossRefPubMedPubMedCentral

Allahverdiye AM, Abamor ES, Bagirova M, Tafailovich M (2011) Antimicrobial effect of TiO₂ and Ag₂O nanoparticles against drug resistant bacteria and Leishmania parasites. Future Microbiol 6(8):933–940. https://doi.org/10.2217/FMB.11.78CrossRef

Ayinmode A, Ndudim NF, Obebe OO (2015) Prevalence of gastrointestinal parasites of rodents in Ibadan, Nigeria. Niger Vet J 36(2):1158–1164

Barbosa ACMS, Silva LPC, Ferraz CM, Tobias FL, de Araújo JV, Loureiro B, Braga GMAM, Veloso FBR, Soares FEF, Fronza M, Braga FR (2019) Nematicidal activity of silver nanoparticles from the fungus Duddingtonia flagrans. Int J Nanomed 14:2341–2348. https://doi.org/10.2147/IJN.S193679CrossRef

Behnke J, Bajer A, Sinski E, Wakelin D (2001) Interactions involving intestinal nematodes of rodents: experimental and field studies. Parasitology 122(S1):S39–S49. https://doi.org/10.1017/S0031182000016796CrossRefPubMed

Bhardwaj R, Saudagar P, Dubey V (2012) Nanobiosciences: a contemporary approach in antiparasitic drugs. Mol Cell Pharmacol 4:97–103

Bhatia D, Mittal A, Malik DK (2016) Antimicrobial activity of PVP coated silver nanoparticles synthesized by Lysinibacillus varians. 3 Biotech 6:196. https://doi.org/10.1007/s13205-016-0514-7CrossRefPubMedPubMedCentral

Brophy PM, Patterson LH, Pritchard DL (1995) Secretory nematode SOD–offensive or defensive? Int J Parasitol 25(7):856–865. https://doi.org/10.1016/0020-7519(95)00005-mCrossRef

Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Meth Enzymol 52:302–310. https://doi.org/10.1016/s0076-6879(78)52032-6CrossRef

Caito SW, Aschner M (2015) Quantification of glutathione in Caenorhabditis elegans. Curr Protoc Toxicol 64:6–18. https://doi.org/10.1002/0471140856.tx0618s64CrossRefPubMedCentral

Chisholm AD, Xu S (2012) The Caenorhabditis elegans epidermis as a model skin II: differentiation and physiological roles. Wiley Interdiscip Rev Dev Biol 1(6):879–902. https://doi.org/10.1002/wdev.77CrossRefPubMedPubMedCentral

Chiumiento L, Bruschi F (2009) Enzymatic antioxidant systems in helminth parasites. Parasitol Res 105(3):593–603. https://doi.org/10.1007/s00436-009-1483-0CrossRefPubMed

Cromwell WA, Yang J, Starr JL, Jo YK (2014) Nematicidal effects of silver nanoparticles on root-knot nematode in Bermudagrass. J Nematol 46(3):261–266PubMedPubMedCentral

Delavari M, Dalimi A, Ghaffarifar F, Sadraei J (2014) In vitro study on cytotoxic effects of ZnO nanoparticles on promastigote and amastigote forms of Leishmania major. Iran J Parasitol 9(1):6–13PubMedPubMedCentral

Dorostkar A, Ghalavand M, Nazarizadeh A, Tat M, Hashemzadeh SM (2017) Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum. Int Nano Lett 7(2):157–164CrossRef

El Mahdy MM, Salah Eldin TA, Aly HS, Mohammed FF, Shaalana MI (2014) Evaluation of hepatotoxic and genotoxic potential of silver nanoparticles in albino rats. Exp Toxicol Pathol 67:21–29. https://doi.org/10.1016/j.etp.2014.09.005CrossRefPubMed

El-Aassar MR, Ibrahim OM, Fouda MMG, El-Beheri NG, Agwa MM (2020) Wound healing of nanofiber comprising polygalacturonic/hyaluronic acid embedded silver nanoparticles: in-vitro and in-vivo studies. Carbohydr Polym 238:116–175. https://doi.org/10.1016/j.carbpol.2020.116175CrossRef

Esmaeilnejad B, Samiei A, Mirzaei Y, Farhang-Pajuh F (2018) Assessment of oxidative/nitrosative stress biomarkers and DNA damage in Haemonchus contortus, following exposure to zinc oxide nanoparticles. Acta Parasitol 63:563–571. https://doi.org/10.1515/ap-2018-0065CrossRefPubMed

Franci G, Falanga A, Galdiero S et al (2015) Silver nanoparticles as potential antibacterial agents. Molecules 20:8856–8874. https://doi.org/10.3390/molecules20058856CrossRefPubMedPubMedCentral

Gang SS, Hallem EA (2016) Mechanisms of host seeking by parasitic nematodes. Mol Biochem Parasitol 208(1):23–32. https://doi.org/10.1016/j.molbiopara.2016.05.007CrossRefPubMedPubMedCentral

Govindarajan M, Benelli G (2015) Facile biosynthesis of silver nanoparticles using Barleria cristata: mosquitocidal potential and biotoxicity on three non-target aquatic organism. Parasitol Res 115:925–935. https://doi.org/10.1007/s00436-015-4817-0CrossRefPubMed

Hagiu BA, Vrinceanu N, Postolache P (2015) The hypothesis regarding the regenerative action of silver nanoparticles. In: E-Health and Bioengineering Conference (EHB), pp 1–4. https://doi.org/10.1109/EHB.2015.7391524

Hillyer JF, Albrecht RM (2001) Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90(12):1927–1936. https://doi.org/10.1002/jps.1143CrossRefPubMed

Hsieh HJ, Liu CA, Huang B, Tseng H, Wang D (2014) Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci 21(1):3. https://doi.org/10.1186/1423-0127-21-3CrossRefPubMedPubMedCentral

Hussein J, El-Naggar ME, Fouda MMG, Morsy OM et al (2020) The efficiency of blackberry loaded Ag NPs, Au NPs and Ag& Au NPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity in experimental rats. Int J Biol Macromol 159:1084–1093. https://doi.org/10.1016/j.ijbiomac.2020.05.115CrossRefPubMed

Ilic V, Krstic A, Katic-Radivojevic S, Jovcic G, Milenkovic P, Bugarski D (2010) Syphacia obvelata modifies mitogen-activated protein kinases and nitric oxide synthases expression in murine bone marrow cells. Parasitol Int 59:82–88CrossRefPubMed

Jabir AF, Shaker AS (2020) Roles of superoxide dismutase (SOD), malondialdehyde (MDA), 8-iso-prostaglandinF2a (8-iso-PGF2a) as oxidative stress in development and progression of Brest cancer in Iraqi females patients. Al-Qadisiyah J Pure Sci 25(1):1–4. https://doi.org/10.29350/jops.2020.25.1.1053

Ji JH, Jung JH, Kim SS, Yoon JU et al (2007) Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague–Dawley rats. Inhal Toxicol 19:857–871. https://doi.org/10.1080/08958370701432108CrossRefPubMed

Khalil AI, Lashein GH, Morsy GH, Abd El-Mottaleb DI (2014) Oxyurids of wild and laboratory rodents from Egypt. Life Sci J 11(3):94–107

Khan YA, Singh BR, Ullah R, Shoeb M, Naqv AH, Abidi SM (2015) Anthelmintic effect of biocompatible zinc oxide nanoparticles (ZnO NPs) on Gigantocotyle explanatum, a neglected parasite of Indian water buffalo. PLoS ONE 10(7):0133086. https://doi.org/10.1371/journal.pone.0133086CrossRef

Kiran T, Karaman U, Arici Y, Yildiz S (2019) Comparison of malondialdehyde, nitric oxide, adenosine deaminase and glutathione levels in patients with Entamoeba coli, Enterobius vermicularis, Giardia intestinalis, Demodex spp. positive, hydatid cyst and Toxoplasma gondii serum positive. Ann Med Res 26:1420CrossRef

Kotze AC (2003) Catalase induction protects Haemonchus contortus against hydrogen peroxide in vitro. Int J Parasitol 33:393–400. https://doi.org/10.1016/s0020-7519(03)00012-2CrossRefPubMed

Kuhnel D, Nickel C (2014) The OECD expert meeting on ecotoxicology and environmental fate—towards the development of improved OECD guidelines for the testing of nano-materials. Sci Total Environ 472:347–353. https://doi.org/10.1016/j.scitotenv.2013.11.055CrossRefPubMed

Lansdown ABG (2006) Silver in health care: antimicrobial effects and safety in use. Curr Probl Dermatol 33:17–34. https://doi.org/10.1159/000093928CrossRefPubMed

Lara HH, Romero-Urbina DG, Pierce C et al (2015) Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study. J Nanobiotech 13(91):2–12. https://doi.org/10.1186/s12951-015-0147-8CrossRef

Li M, Zhu L, Lin D (2011) Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. Environ Sci Technol 45(5):1977–1983CrossRefPubMed

Lim D, Roh JY, Eom HJ, Hyun JW, Choi J (2012) Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans. Environ Toxicol Chem 31:585–592. https://doi.org/10.1002/etc.1706CrossRefPubMed

Lotfy BMM, Mousa MR, El-Shehry MSFE et al (2022) Therapeutic potency of Gallium verum extract on ethanol-induced gastric ulcer in rats. Biointerface Res Appl Chem 12:6010–6020. https://doi.org/10.33263/BRIAC125.60106020

Mamdouh S, Mohamed AS, Mohamed HA, Fahmy WS (2022) Zn contamination stimulate agonistic behavior and oxidative stress of crayfishes (Procambarus clarkii). J Trace Elem Med Biol 69:126895. https://doi.org/10.1016/j.jtemb.2021.126895CrossRefPubMed

Massetti M, Locci T, Cecchettini A et al (2004) Nitric oxide synthase immunoreactivity in the nematode Trichinella britovi. Evidence for nitric oxide production by the parasite. Int J Parasitol 34:715–721. https://doi.org/10.1016/j.ijpara.2004.02.002CrossRef

Mclaughlin S, Podrebarac J, Ruel M (2016) Nano-engineered biomaterials for tissue regeneration: What has been achieved so far? Front Mater 3:1–28CrossRef

Meade TM, Watson J (2014) Characterization of rat pinworm (Syphacia muris) epidemiology as a means to increase detection and elimination. J Am Assoc Lab Anim Sci 53:661–667PubMedPubMedCentral

Meyer JN, Lord CA, Yang XY et al (2010) Intracellular uptake and associated toxicity of silver nano articles in Caenorhabditis elegans. Aquat Toxicol 100:140–150. https://doi.org/10.1016/j.aquatox.2010.07.016CrossRefPubMed

Okorafor KA, Odaibo AB, Eleng IE, Okete JA (2012) Occurrence and prevalence of ecto- and gastrointestinal parasites in cane rats (Thryonomyss winderianus) from Oyo State, south-western Nigeria. Eur J Zoo Res 1(3):70–76

Omar TY, Elshenawy HIA, Abdelfattah MA, Al Shawoush AM, Mohamed AS, Saad DY (2023) Biointerfrence between zinc oxide/alginate nanocomposites and freshwater bivalve. Biointerface Res Appl Chem 13(3):277. https://doi.org/10.33263/BRIAC133.27

Pillai RK, John SS, Joseph CT, Chandramohanakumar N, Balagopalan M (2012) Vermifugal activity of biofabricated silver nanoparticles. Res J Recent Sci 1:47–51

Pinto RM, Vicente JJ, Noronha D, Gonçalves L, Gomes DC (1994) Helminth parasites of conventionally maintained laboratory mice. Mem Inst Oswaldo Cruz 89:33–40. https://doi.org/10.1590/s0074-02761994000100007CrossRefPubMed

Pinto RM, Goncalves L, Noronha D, Gomes DC (2001) Worm burdens in outbred and inbred laboratory rats with morphometric data on Syphacia muris (Yamaguti, 1935) Yamaguti, 1941 (Nematoda, Oxyuroidea). Mem Inst Oswaldo Cruz. Rio de Janeiro 96(1):133–136. https://doi.org/10.1590/s0074-02762001000100016

Pritchard MH, Kruse GOW (1982) The collection and preservation of animal parasites. Technical Bulletin No. 1, The Harold W. Manter Laboratory. University of Nebraska Press, Lincoln. 141

Roh JY, Sim SJ, Yi J, Park K, Chung KH, Ryu DY (2009) Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. Environ Sci Technol 43(10):3933–3940. https://doi.org/10.1021/es803477uCrossRefPubMed

Ross LE, Dykstra M (2003) Biological electron microscopy: theory, techniques and troubleshooting. Springer, USA

Salt IP, Morrow VA, Brandie FM, Connell JM, Petrie JR (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells. J Biol Chem 278:18791–18797. https://doi.org/10.1074/jbc.M210618200CrossRefPubMed

Sato Y, Ooi HK, Nonaka N, Oku Y, Kamiya M (1995) Antibody production in Syphacia obvelata-infected mice. J Parasitol 81:559–562CrossRefPubMed

Song S, Guo Y, Zhang X, Zhang X, Zhang J, Ma E (2014) Changes to cuticle surface ultrastructure and some biological functions in the nematode Caenorhabditis elegans exposed to excessive copper. Arch Environ Contam Toxicol 66(3):390–399. https://doi.org/10.1007/s00244-013-9991-4CrossRefPubMed

Stebounova LV, Adamcakova Dodd A, Kim JS et al (2011) Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model. Part Fibre Toxicol 8:5. https://doi.org/10.1186/1743-8977-8-5CrossRefPubMedPubMedCentral

Sueta T, Miyoshi I, Okamura T, Kasai N (2002) Experimental eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) from mice colonies using ivermectin. Exp Anim 51:367–373CrossRefPubMed

Sung JH, Ji JH, Song KS, Lee JH et al (2011) Acute inhalation toxicity of silver nanoparticles. Toxicol Ind Health 27:149–154. https://doi.org/10.1177/0748233710382540CrossRefPubMed

Tomar RS, Preet S (2016) Evaluation of anthelmintic activity of biologically synthesized silver nanoparticles against the gastrointestinal nematode, Haemonchus contortus. J Helmin 91(4):1–8. https://doi.org/10.1017/S0022149X16000444CrossRef

Torres-Acosta JF, Mendoza-de-Gives P, Aguilar-Caballero AJ, Cuéllar-Ordaz JA (2012) Anthelmintic resistance in sheep farms: update of the situation in the American continent. Vet Parasitol 189:89–96. https://doi.org/10.1016/j.vetpar.2012.03.037CrossRefPubMed

Unfried K, Albrecht C, Klotz LO et al (2007) Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1(1):52–71CrossRef

Urie R, Ghosh D, Ridha I, Rege K (2018) Inorganic nanomaterials for soft tissue repair and regeneration. Annu Rev Biomed Eng 20:353–374. https://doi.org/10.1146/annurev-bioeng-071516-044457CrossRefPubMed

Wang Q, Rosa BA, Jasmer DP, Mitreva M (2015) Pan-Nematoda transcriptomic elucidation of essential intestinal functions and therapeutic targets with broad potential. Ebio Medicine 2(9):1079–1089. https://doi.org/10.1016/j.ebiom.2015.07.030CrossRef

Wei L, Lu J, Xu H, Patel A, Chen ZS, Chen G (2015) Silver nanoparticles: synthesis, properties, and therapeutic applications. Drug Discov Today 20:595–601. https://doi.org/10.1016/j.drudis.2014.11.014CrossRefPubMed

Xiang Y, Li J, Liu X, Cui Z, Yang X, Yeung KWK, Pan H, Wu S (2017) Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility. Mater Sci Eng C Mater Biol Appl 79:629–637. https://doi.org/10.1016/j.msec.2017.05.115CrossRefPubMed

Xiong D, Fang T, Yu L, Sima X, Zhu W (2011) Effects of nano-scale TiO₂, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409(8):1444–1452. https://doi.org/10.1016/j.scitotenv.2011.01.015CrossRefPubMed

Youssef FS, Elbanna HA, Elzorba HY et al (2020) Synthesis and characterization of florfenicol-silver nanocomposite and its antibacterial activity against some gram positive and gram-negative bacteria. Int J Vet Sci. 9(3):324–330

Youssef A, Baiomy A, Fahmy SR, Mohamed AS, Saad D, Desoky R (2022) Potential anti-osteoporotic effect of Allolobophora caliginosa extract in orchiectomized rats. Pharm. Sci. Asia 49:138–146. https://doi.org/10.29090/psa.2022.02.21.144

Yu KN, Yoon TJ, Tehrani AM, Kim JE, Park SJ, Jeong MS et al (2013) Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro 27:1187–1195. https://doi.org/10.1016/j.tiv.2013.02.010CrossRefPubMed

Zhang F, You X, Zhu T, Gao S, Wang Y, Wang R, Yu H, Qian B (2020) Silica nanoparticles enhance germ cell apoptosis by inducing reactive oxygen species (ROS) formation in Caenorhabditis elegans. J Toxicol Sci 45(3):117–129. https://doi.org/10.2131/jts.45.117CrossRefPubMed

Zhang X-F, Liu Z-G, Shen W, Gurunathan S (2016) Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci 17:1534. https://doi.org/10.3390/ijms17091534CrossRefPubMedPubMedCentral

Zhang Z, Shen W, Xue J, Liu Y et al (2018) Recent advances in synthetic methods and applications of silver nanostructures. Nano-Scale Res Lett 13(1):54. https://doi.org/10.1186/s11671-018-2450-4CrossRef

Titel: In vivo efficacy of silver nanoparticles against Syphacia muris infected laboratory Wistar rats
verfasst von: Mona Fathi Fol
Salwa Abdel-Hamid Hamdi
Heba Ali Abdel-Rahman
Nesma Abbas Mostafa
Publikationsdatum: 05.08.2023
Verlag: Springer India
Erschienen in: Journal of Parasitic Diseases / Ausgabe 4/2023
Print ISSN: 0971-7196
Elektronische ISSN: 0975-0703
DOI: https://doi.org/10.1007/s12639-023-01607-5

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In vivo efficacy of silver nanoparticles against Syphacia muris infected laboratory Wistar rats

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