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08.01.2019 | Retinal Disorders | Ausgabe 4/2019

Graefe's Archive for Clinical and Experimental Ophthalmology 4/2019

In vivo imaging of the fibrillar architecture of the posterior vitreous and its relationship to the premacular bursa, Cloquet’s canal, prevascular vitreous fissures, and cisterns

Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 4/2019
Orly Gal-Or, Quraish Ghadiali, Rosa Dolz-Marco, Michael Engelbert
Wichtige Hinweise
Orly Gal-Or and Quraish Ghadiali contributed equally to this work.
The manuscript content was presented at the Association for Research in Vision and Ophthalmology Annual Meeting 2017 in Baltimore Maryland on May 8, 2017.

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To describe the fibrillar architecture of the posterior cortical vitreous and identify variations across eyes of different axial lengths in vivo.


Sixty-four eyes of 32 subjects were examined with swept-source optical coherence tomography (SS-OCT). Grading of vitreous degeneration, presence of vitreous cisterns/lacunae, posterior hyaloid status, directionality of vitreous fibers and their relations to vitreous spaces, and lamellar reflectivity of the posterior vitreous were assessed.


A consistent pattern of fibrillar organization was discovered. Eyewall parallel fibers formed a dense meshwork over the retinal surface and fibers oriented in a perpendicular fashion to this meshwork were found to envelop the various vitreous spaces, intersecting at variable angles of insertion to the eyewall parallel fibers. Lamellar reflectivity suggestive of splitting of the cortical fibrillar meshwork was detected in 27 eyes (42%) with 56% of these eyes demonstrating perpendicularly oriented intersecting fibers. Fifty-six percent of eyes with lamellar reflectivity had an axial length > 25 mm.


SS-OCT imaging revealed fibrillar organization of the posterior vitreous. Eye wall parallel hyperreflectivity of cortical vitreous was a universal finding. This pattern is suggestive of a splitting of cortical vitreous tissue and may represent a precursor to vitreoschisis. Perpendicular fibers appear to be important constituents of the walls of the various liquid vitreous spaces.

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