Skip to main content
main-content

21.06.2017 | Osteocytes (T Bellido and J Klein-Nulend, Section Editors) | Ausgabe 4/2017

Current Osteoporosis Reports 4/2017

In vivo Visualisation and Quantification of Bone Resorption and Bone Formation from Time-Lapse Imaging

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 4/2017
Autoren:
Patrik Christen, Ralph Müller
Wichtige Hinweise
This article is part of the Topical Collection on Osteocytes

Abstract

Purpose of Review

Mechanoregulation of bone cells was proposed over a century ago, but only now can we visualise and quantify bone resorption and bone formation and its mechanoregulation. In this review, we show how the newest advances in imaging and computational methods paved the way for this breakthrough.

Recent Findings

Non-invasive in vivo assessment of bone resorption and bone formation was demonstrated by time-lapse micro-computed tomography in animals, and by high-resolution peripheral quantitative computed tomography in humans. Coupled with micro-finite element analysis, the relationships between sites of bone resorption and bone formation and low and high tissue loading, respectively, were shown.

Summary

Time-lapse in vivo imaging and computational methods enabled visualising and quantifying bone resorption and bone formation as well as its mechanoregulation. Future research includes visualising and quantifying mechanoregulation of bone resorption and bone formation from molecular to organ scales, and translating the findings into medicine using personalised bone health prognosis.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2017

Current Osteoporosis Reports 4/2017 Zur Ausgabe

Osteoimmunology (M Humphrey and M Nakamura, Section Editors)

Osteoimmunology in Bone Fracture Healing

Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller, Section Editors)

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

Pediatrics (L Ward and E Imel, Section Editors)

Denosumab: an Emerging Therapy in Pediatric Bone Disorders

Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors)

Using Osteoporosis Therapies in Combination

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise