Background
Methods
Patient population
Statistical analysis
Results
Incidence rate and median age of onset of renal replacement therapy in PKD
Year | Incident Rate of ESKD due to PKD (million population per year) | Lower 95% CI | Upper 95% CI |
---|---|---|---|
1970–1974 | 2.04 | 1.71 | 2.42 |
1975–1979 | 2.50 | 2.18 | 2.85 |
1980–1984 | 3.15*
| 2.80 | 3.54 |
1985–1989 | 3.92*
| 3.54 | 4.33 |
1990–1994 | 4.53*
| 4.13 | 4.95 |
1995–1999 | 5.62*
| 5.18 | 6.08 |
2000–2004 | 5.69*
| 5.26 | 6.14 |
2005–2009 | 7.63*
| 7.15 | 8.12 |
2010–2014 | 6.57*
| 6.15 | 7.02 |
Characteristics of the initial modality of renal replacement therapy in PKD
PKD | 0.5 years | 1 year | 3 years | 5 years |
1963–1974 | 58.5 [49.3–0.66.7] | 53.7 [44.5–0.62.0] | 44.7 [35.8–53.2] | 37.4 [28.9–45.9] |
1975–1984 | 56.9 [51.5–61.9] | 53.5 [48.1–58.5] | 47.1 [41.7–52.2] | 40.1 [34.9–45.2] |
1985–1994 | 84.3 [80.9–87.2] | 83.2 [79.7–86.1] | 78.0 [74.1–81.3] | 74.5 [70.5–78.0] |
1995–2004 | 93.0 [90.8–94.7] | 91.8 [89.5–93.7] | 88.6 [86.0–90.8] | 84.2 [81.2–86.8] |
2005–2014 | 97.6 [96.5–98.3] | 97.1 [96.0–97.9] | 93.9 [92.2–95.2] | 90.4 [88.2–92.2] |
Non-PKD | ||||
Total | ||||
1963–1974 | 63.1 [60.7–65.3] | 58.1 [55.7–60.5] | 48.5 [46.1–0.50.8] | 42.1 [39.7–44.4] |
1975–1984 | 63.5 [62.0–65.0] | 58.7 [57.1–60.2] | 48.4 [46.8–50.0] | 42.3 [40.7–43.9] |
1985–1994 | 84.9 [83.9–85.9] | 82.7 [81.6–83.7] | 74.8 [73.6–76.0] | 67.3 [65.9–68.6] |
1995–2004 | 92.7 [92.0–93.3] | 91.3 [90.5–92.0] | 85.9 [84.9–86.7] | 79.7 [78.6–80.7] |
2005–2014 | 95.8 [95.4–96.3] | 94.4 [93.9–95.0] | 89.1 [88.3–89.8] | 83.3 [82.3–84.3] |
Diabetic/Vascular | ||||
1963–1974 | 52.4 [43.3–60.8] | 46.8 [37.8–55.2] | 36.9 [28.5–45.4] | 34.5 [26.2–42.9] |
1975–1984 | 51.9 [46.7–56.8] | 46.3 [41.2–51.2] | 34.7 [29.9–39.5] | 27.8 [23.3–32.3] |
1985–1994 | 83.4 [80.1–86.3] | 80.0 [76.5–83.1] | 70.8 [66.8–74.3] | 61.3 [57.2–65.2] |
1995–2004 | 91.2 [89.1–92.9] | 89.5 [87.3–91.4] | 82.0 [79.3–84.4] | 75.7 [72.6–78.4] |
2005–2014 | 94.7 [93.5–95.7] | 93.0 [91.6–94.1] | 86.1 [84.1–87.9] | 80.1 [77.5–82.3] |
Non-vascular | ||||
1963–1974 | 63.9 [61.5–66.2] | 59.0 [56.6–61.4] | 49.4 [46.9–51.8] | 42.7 [40.3–45.2] |
1975–1984 | 64.8 [63.2–66.4] | 60.0 [58.4–61.6] | 49.9 [48.3–51.6] | 43.9 [42.2–45.6] |
1985–1994 | 85.1 [84.0–86.1] | 83.0 [81.8–84.1] | 75.4 [74.1–76.6] | 68.1 [66.6–69.4] |
1995–2004 | 93.0 [92.2–93.6] | 91.6 [90.7–92.3] | 86.5 [85.5–87.5] | 80.4 [79.3–81.5] |
2005–2014 | 96.1 [95.6–96.6] | 94.9 [94.3–95.4] | 89.8 [89.0–90.6] | 84.1 [83.0–85.2] |
Survival and death rates on renal replacement therapy in PKD
PKD | 0.5 years | 1 year | 3 years | 5 years |
1963–1974 | 90.7 [85.3–94.2] | 82.0 [75.4–87.0] | 64.0 [56.3–70.6] | 52.3 [44.6–59.5] |
1975–1984 | 97.0 [95.1–98.2] | 92.9 [90.3–94.8] | 76.7 [72.8–80.2] | 65.5 [61.2–69.4] |
1985–1994 | 97.0 [95.6–97.9] | 94.3 [92.5–95.7] | 82.9 [80.2–85.3] | 72.1 [69.0–75.0] |
1995–2004 | 98.3 [97.4–98.9] | 96.1 [94.9–97.1] | 85.8 [83.8–87.6] | 77.7 [75.3–79.9] |
2005–2014 | 98.5 [97.8–99.0] | 97.1 [96.2–97.8] | 91.2 [89.6–92.5] | 85.1 [83.1–86.9] |
Non-PKD | ||||
Total | ||||
1963–1974 | 88.1 [86.7–89.4] | 79.6 [77.9–81.3] | 61.5 [59.5–63.5] | 52.4 [50.3–54.5] |
1975–1984 | 93.3 [92.6–93.9] | 86.6 [85.7–87.5] | 69.9 [68.7–71.1] | 58.9 [57.6–60.1] |
1985–1994 | 94.6 [94.2–95.0] | 89.2 [88.6–89.8] | 68.7 [67.7–69.5] | 54.4 [53.5–55.4] |
1995–2004 | 93.8 [93.5–94.1] | 87.6 [87.1–88.1] | 66.5 [65.9–67.2] | 51.1 [50.4–51.8] |
2005–2014 | 94.0 [93.7–94.3] | 89.1 [88.7–89.4] | 70.4 [69.8–71.0] | 55.2 [55.5–56.0] |
Diabetic/Vascular | ||||
1963–1974 | 79.9 [73.4–84.9] | 68.8 [61.7–74.9] | 43.4 [36.3–50.3] | 38.1 [31.2–45.0] |
1975–1984 | 87.0 [84.4–89.1] | 76.4 [73.3–79.2] | 50.3 [46.8–53.8] | 35.6 [32.3–39.0] |
1985–1994 | 92.1 [91.0–93.6] | 84.0 [83.6–85.4] | 52.6 [50.6–54.4] | 33.3 [31.4–35.0] |
1995–2004 | 92.7 [92.2–93.3] | 85.1 [84.3–85.8] | 58.0 [56.9–59.0] | 38.0 [36.9–39.0] |
2005–2014 | 94.0 [93.6–94.3] | 88.3 [87.8–88.8] | 65.6 [64.7–66.4] | 46.6 [45.6–47.6] |
Non-vascular | ||||
1963–1974 | 88.9 [87.5–90.2] | 80.7 [78.9–82.3] | 63.3 [61.1–65.3] | 53.8 [51.6–55.9] |
1975–1984 | 94.3 [93.6–94.9] | 88.3 [87.3–89.1] | 73.1 [71.8–74.3] | 62.6 [61.3–64.0] |
1985–1994 | 95.5 [95.0–95.9] | 91.0 [90.3–91.6] | 74.2 [73.2–75.2] | 61.9 [60.8–63.0] |
1995–2004 | 94.6 [94.2–95.0] | 89.5 [88.9–90.0] | 72.9 [72.0–73.7] | 60.8 [59.9–61.7] |
2005–2014 | 94.0 [93.6–94.4] | 90.0 [89.4–90.4] | 75.8 [74.9–76.6] | 65.7 [63.7–65.7] |
PKD | 0.5 years | 1 year | 3 years | 5 years |
1963–1974 | 85.0 | 71.8 | 46.9 | 32.8 |
1975–1984 | 96.0 | 90.4 | 69.0 | 54.4 |
1985–1994 | 97.0 | 94.3 | 82.2 | 69.7 |
1995–2004 | 98.7 | 97.1 | 88.6 | 81.1 |
2005–2014 | 99.0 | 98.1 | 93.7 | 88.8 |
Non-PKD | ||||
Total | ||||
1963–1974 | 78.3 | 64.1 | 38.1 | 27.2 |
1975–1984 | 89.7 | 79.7 | 55.3 | 39.9 |
1985–1994 | 94.3 | 88.4 | 64.8 | 47.2 |
1995–2004 | 95.2 | 90.1 | 71.1 | 54.7 |
2005–2014 | 95.5 | 91.8 | 76.2 | 61.7 |
Diabetic/vascular | ||||
1963–1974 | 64.5 | 47.6 | 18.2 | 13.7 |
1975–1984 | 83.2 | 70.2 | 39.8 | 24.2 |
1985–1994 | 92.0 | 83.6 | 51.4 | 30.8 |
1995–2004 | 94.1 | 87.7 | 63.3 | 43.0 |
2005–2014 | 95.4 | 91.0 | 71.9 | 54.1 |
Non-vascular | ||||
1963–1974 | 79.9 | 65.8 | 40.3 | 28.7 |
1975–1984 | 91.1 | 81.7 | 58.7 | 43.5 |
1985–1994 | 95.1 | 90.0 | 70.0 | 53.7 |
1995–2004 | 95.7 | 91.4 | 76.1 | 62.7 |
2005–2014 | 95.5 | 92.3 | 80.2 | 69.3 |
PKD | 0.5 years | 1 year | 3 years | 5 years |
1963–1974 | 96.2 [90.9–98.4] | 90.9 [82.7–95.4] | 73.7 [59.3–83.7] | 51.3 [34.2–66.0] |
1975–1984 | 98.5 [97.0–99.3] | 94.8 [92.2–96.6] | 80.8 [75.6–85.0] | 62.5 [55.3–68.8] |
1985–1994 | 96.9 [95.5–97.9] | 94.0 [92.1–95.5] | 79.9 [76.4–82.9] | 59.9 [55.0–64.3] |
1995–2004 | 98.3 [97.4–98.9] | 95.9 [94.5–96.9] | 83.1 [80.5–85.3] | 69.4 [66.1–72.5] |
2005–2014 | 98.3 [97.6–98.9] | 96.6 [95.5–97.4] | 87.6 [85.4–89.5] | 77.7 [74.4–80.6] |
Non-PKD | ||||
Total | ||||
1963–1974 | 92.7 [91.4–93.8] | 87.1 [85.1–88.8] | 66.9 [62.9–70.6] | 55.1 [50.1–59.8] |
1975–1984 | 93.8 [93.1–94.4] | 87.1 [86.1–88.1] | 64.6 [62.9–66.2] | 45.9 [43.9–47.9] |
1985–1994 | 94.5 [94.1–95.0] | 88.7 [87.9–89.2] | 61.9 [60.8–63.0] | 40.2 [39.0–41.4] |
1995–2004 | 93.6 [93.3–94.0] | 87.0 [86.5–87.5] | 62.7 [62.0–63.4] | 42.9 [42.1–43.7] |
2005–2014 | 93.7 [93.4–94.0] | 88.5 [88.1–88.9] | 67.3 [66.6–67.9] | 48.5 [47.7–49.3] |
Diabetic/Vascular | ||||
1963–1974 | 83.6 [76.8–88.5] | 77.7 [69.7–83.8] | 55.6 [42.5–66.8] | 51.9 [37.8–64.3] |
1975–1984 | 88.7 [86.1–90.8] | 78.1 [74.7–81.0] | 47.6 [43.1–52.0] | 25.3 [21.0–29.8] |
1985–1994 | 92.0 [90.9–93.0] | 83.5 [82.0–84.9] | 48.4 [46.4–50.5] | 24.9 [23.1–26.8] |
1995–2004 | 92.7 [92.1–0.93.2] | 84.8 [84.1–85.6] | 56.2 [55.1–57.3] | 34.1 [33.0–35.2] |
2005–2014 | 93.9 [93.5–94.3] | 88.2 [87.6–88.7] | 64.2 [63.3–65.0] | 43.5 [42.4–44.5] |
Non-vascular | ||||
1963–1974 | 93.6 [92.2–94.7] | 88.0 [86.0–89.8] | 68.0 [63.8–71.9] | 55.6 [50.3–60.6] |
1975–1984 | 94.6 [93.9–95.3] | 88.6 [87.6–89.69] | 67.6 [65.8–69.3] | 49.8 [47.6–52.0] |
1985–1994 | 95.5 [95.0–95.9] | 90.4 [89.7–91.1] | 67.7 [66.4–68.9] | 47.3 [45.8–48.8] |
1995–2004 | 94.4 [93.9–94.8] | 88.7 [88.1–89.3] | 68.3 [67.3–69.3] | 51.1 [50.0–52.2] |
2005–2014 | 93.5 [93.1–94.0] | 89.0 [88.4–89.6] | 71.5 [70.5–72.4] | 55.7 [54.4–56.9] |
PKD | 0.5 years | 1 year | 3 years | 5 years |
1963–1974 | 92.6 | 83.3 | 56.0 | 26.4 |
1975–1984 | 98.1 | 93.4 | 77.5 | 58.2 |
1985–1994 | 96.9 | 94.1 | 80.7 | 62.5 |
1995–2004 | 98.5 | 96.4 | 85.5 | 73.8 |
2005–2014 | 98.8 | 97.5 | 91.0 | 83.9 |
Non-PKD | ||||
Total | ||||
1963–1974 | 86.1 | 76.4 | 47.4 | 33.7 |
1975–1984 | 91.2 | 82.4 | 56.1 | 37.1 |
1985–1994 | 94.1 | 87.7 | 60.8 | 39.0 |
1995–2004 | 94.4 | 88.6 | 66.6 | 47.5 |
2005–2014 | 95.0 | 90.8 | 73.0 | 56.0 |
Diabetic/vascular | ||||
1963–1974 | 69.1 | 59.3 | 29.2 | 25.2 |
1975–1984 | 86.7 | 74.7 | 42.4 | 20.6 |
1985–1994 | 91.9 | 83.3 | 48.2 | 24.8 |
1995–2004 | 93.6 | 86.7 | 60.4 | 38.5 |
2005–2014 | 95.1 | 90.4 | 69.9 | 50.7 |
Non-vascular | ||||
1963–1974 | 87.8 | 78.1 | 49.4 | 34.8 |
1975–1984 | 92.2 | 83.9 | 58.9 | 40.6 |
1985–1994 | 94.9 | 89.5 | 66.4 | 45.9 |
1995–2004 | 95.0 | 90.0 | 71.7 | 55.3 |
2005–2014 | 94.8 | 91.1 | 76.7 | 62.8 |