Background
Methods
Definition of peripheral artery disease incidence
Progression of the illness
Statistical methods
Ethics
Results
Without PAD | With PAD | Total | |||||
---|---|---|---|---|---|---|---|
n = 2161 | n = 95 | na = 2256 | |||||
n | % | n | % | n | % |
p
| |
Men | 887 | 41 % | 46 | 48 % | 933 | 41 % | 0.153 |
Age (mean, SD) | 63 | 7.7 | 66 | 9.0 | 63 | 7.8 | 0.000 |
Age category | 0.023 | ||||||
49–64 | 1337 | 62 % | 46 | 48 % | 1383 | 61 % | |
65–69 | 376 | 17 % | 20 | 21 % | 396 | 18 % | |
70–86 | 448 | 21 % | 29 | 31 % | 477 | 21 % | |
Education level | 0.332 | ||||||
Illiterate | 97 | 5 % | 7 | 8 % | 104 | 5 % | |
Primary education | 1482 | 72 % | 63 | 69 % | 1545 | 72 % | |
Secondary education | 408 | 20 % | 20 | 22 % | 428 | 20 % | |
University | 73 | 4 % | 1 | 1 % | 74 | 3 % | |
Smoking habit | 0.000 | ||||||
Never smoker | 1285 | 59 % | 37 | 39 % | 1322 | 58.6 % | |
Former smoker | 532 | 25 % | 31 | 33 % | 563 | 25.0 % | |
Current smoker | 344 | 16 % | 27 | 28 % | 371 | 16.4 % | |
Physical activity in leisure timeb (mean, SD) | 5.8 | 3.5 | 4.7 | 3.7 | 5.8 | 3.6 | 0.009 |
Physical activity limitations | 0.000 | ||||||
None | 933 | 44 % | 21 | 22 % | 954 | 43 % | |
Moderate | 1052 | 49 % | 56 | 60 % | 1108 | 50 % | |
Can only do light activities | 142 | 7 % | 13 | 14 % | 155 | 7 % | |
Any activity causes breathlessness | 15 | 1 % | 4 | 4 % | 19 | 1 % | |
Body mass index (Kg/m2) (mean, SD) | 29 | 4.5 | 30 | 5.6 | 29 | 4.6 | 0.091 |
Central obesityc | 1283 | 60 % | 63 | 66 % | 1346 | 60 % | 0.196 |
Morbidity (clinical record) | |||||||
Hypertension | 891 | 42 % | 57 | 62 % | 948 | 43 % | 0.000 |
Hypercholesterolemia | 1015 | 48 % | 50 | 53 % | 1065 | 48 % | 0.334 |
Diabetes | 268 | 12 % | 21 | 22 % | 289 | 13 % | 0.006 |
High LDL (>130 mg/dl) | 1225 | 57 % | 53 | 56 % | 1278 | 57 % | 0.783 |
Low HDL (<40 mg/dl men, <50 mg/dl women) | 410 | 19 % | 30 | 32 % | 440 | 20 % | 0.002 |
High triglycerides (>150 mg/dl) | 506 | 24 % | 27 | 28 % | 533 | 24 % | 0.286 |
Atherogenic dyslipidaemia | 199 | 9 % | 11 | 12 % | 210 | 9 % | 0.437 |
REGICOR scored | 0.000 | ||||||
≤ 5 % | 1253 | 64 % | 32 | 43 % | 1285 | 64 % | |
5–10 % | 524 | 27 % | 27 | 36 % | 551 | 27 % | |
> 10 % | 166 | 9 % | 16 | 21 % | 182 | 9 % | |
Framingham scored | 0.000 | ||||||
≤ 10 % | 940 | 48 % | 24 | 32 % | 964 | 48 % | |
10–20 % | 669 | 34 % | 24 | 32 % | 693 | 34 % | |
> 20 % | 334 | 17 % | 27 | 36 % | 361 | 18 % | |
Ankle SBP (minimum of both legs) (mmHg) (mean, SD) | 147 | 21 | 144 | 24 | 147 | 21 | 0.124 |
Control brachial SBP (mmHg) (mean, SD) | 135 | 18 | 142 | 20 | 135 | 18 | 0.000 |
Ankle-brachial index (minimum of both legs) (mean, SD) | 1.10 | 0.10 | 1.01 | 0.09 | 1.09 | 0.10 | 0.000 |
Overall | Men | Women | |||||||
---|---|---|---|---|---|---|---|---|---|
Cases | Ia | CI 95 % | Cases | Ia | CI 95 % | Cases | Ia | CI 95 % | |
PAD | 95 | 8.6 | 6.9–10.5 | 46 | 10.2 | 7.4–13.5 | 49 | 7.5 | 5.5–9.9 |
Symptomatic PADb | 18 | 1.6 | 1.0–2.6 | 11 | 2.4 | 1.2–4.3 | 7 | 1.1 | 0.4–2.2 |
Assymptomatic PADb | 71 | 6.4 | 5.0–8.1 | 34 | 7.5 | 5.2–10.5 | 37 | 5.6 | 4.0–7.8 |
Baseline variablesa | HR | CI 95 % |
p
|
---|---|---|---|
Men | 1.81 | 1.20–2.71 | 0.011 |
Age (by year) | 1.04 | 1.01–1.06 | 0.006 |
Education level | |||
Illiterate | 1.00 | ||
Primary education | 0.71 | 0.32–1.57 | 0.288 |
Secondary education or University | 0.85 | 0.35–2.07 | 0.385 |
Smoking habit | |||
Never smoker | 1.00 | ||
Former smoker | 2.69 | 1.45–5.01 | 0.002 |
Current smoker | 3.78 | 2.01–7.11 | 0.000 |
Physical activity in leisure timeb (mean, SD) | 0.97 | 0.90–1.05 | 0.498 |
Physical activity limitations | |||
None | 1.00 | ||
Moderate | 2.03 | 1.20–3.42 | 0.008 |
Can only do light activities or any activity causes breathlessness | 2.55 | 1.31–4.97 | 0.006 |
Body mass index (Kg/m2) (mean, SD) | 1.03 | 0.98–1.07 | 0.234 |
Central obesityc | 1.10 | 0.70–1.73 | 0.690 |
Morbidity (clinical record) | |||
Hypertension | 1.71 | 1.09–2.67 | 0.018 |
Hypercholesterolemia | 0.98 | 0.65–1.47 | 0.905 |
Diabetes | 1.73 | 1.06–2.84 | 0.028 |
High LDL (>130 mg/dl) | 0.89 | 0.59–1.34 | 0.577 |
Low HDL (<40 mg/dl men, <50 mg/dl women) | 1.82 | 1.17–2.82 | 0.008 |
High triglycerides (>150 mg/dl) | 1.05 | 0.66–1.65 | 0.846 |
Atherogenic dyslipidaemia | 1.11 | 0.58–2.12 | 0.742 |
Baseline variablesb | HR | CI 95 % |
p
|
---|---|---|---|
Age (by year) | 1.04 | 1.01–1.07 | 0.003 |
Low HDL (<40 mg/dl men, <50 mg/dl women) | 1.68 | 1.08–2.63 | 0.023 |
Moderate limitation of physical activities | 1.99 | 1.18–3.37 | 0.010 |
Only light activities or any activity causes breathlessness | 2.36 | 1.21–4.63 | 0.011 |
Former smoker | 2.49 | 1.53–4.05 | 0.000 |
Current smoker | 3.49 | 2.07–5.90 | 0.000 |
Baseline variablesa | OR | CI 95 % |
p
|
---|---|---|---|
Age (by year) | 1.03 | 1.01–1.04 | 0.001 |
Education level | |||
Illiterate | 1.00 | ||
Primary education | 0.52 | 0.33–0.83 | 0.005 |
Secondary education or University | 0.65 | 0.39–1.08 | 0.097 |
Smoking habit | |||
Never smoker | 1.00 | ||
Former smoker | 1.42 | 1.08–1.85 | 0.011 |
Current smoker | 2.04 | 1.51–2.75 | 0.000 |
Physical activity limitations | |||
None | 1.00 | ||
Moderate | 1.34 | 1.05–1.72 | 0.018 |
Only light activities or any activity causes breathlessness | 1.22 | 0.78–1.90 | 0.388 |