Erschienen in:
01.12.2013 | Original Article
Incidence of steroid-associated osteonecrosis of the talus: a prospective MRI study
verfasst von:
Tomonori Shigemura, Junichi Nakamura, Yoshitada Harada, Masaaki Sakamoto, Kazuhisa Takahashi, Shunji Kishida
Erschienen in:
European Orthopaedics and Traumatology
|
Ausgabe 4/2013
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Abstract
Objective
The purpose of this study was to determine the incidence of steroid-associated osteonecrosis (ON) of the talus in systemic lupus erythematosus (SLE) patients using a prospective magnetic resonance imaging (MRI) study.
Methods
We prospectively evaluated 110 SLE patients (220 tali) who required corticosteroid therapy using MRI. The incidence of ON of the talus was compared with the incidence of ON of the femoral head. We also divided these patients into two groups: those with and without ON of the talus. We compared these groups for gender differences, ages at initial corticosteroid therapy, and highest daily corticosteroid dosages.
Results
The incidence of ON of the talus was significantly lower than the incidence of ON of the femoral head (7.3 versus 49.5 %; p < 0.001). No significant differences for gender, age at initial corticosteroid therapy, or highest daily corticosteroid dosage were observed between patients with and without ON of the talus. The rate of ON of the bilateral femoral head was significantly higher in those with ON of the talus than in those without ON of the talus.
Conclusion
Our results revealed that the incidence of ON of the talus was significantly lower than the incidence of ON of the femoral head.