Skip to main content
Erschienen in: Journal of Neuro-Oncology 2/2017

04.02.2017 | Clinical Study

Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma

verfasst von: Maryam Shabihkhani, Donatello Telesca, Masoud Movassaghi, Yalda B. Naeini, Kourosh M. Naeini, Seyed Amin Hojat, Diviya Gupta, Gregory M. Lucey, Michael Ontiveros, Michael W. Wang, Lauren S. Hanna, Desiree E. Sanchez, Sergey Mareninov, Negar Khanlou, Harry V. Vinters, Marvin Bergsneider, Phioanh Leia Nghiemphu, Albert Lai, Linda M. Liau, Timothy F. Cloughesy, William H. Yong

Erschienen in: Journal of Neuro-Oncology | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data from 2001 to 2011 draws from 28% of the U.S. population. Latinos have a lower incidence of GBM and present slightly younger than non-Latino Whites. Cubans present at an older age than other Latino sub-populations. Latinos have a higher incidence of giant cell glioblastoma than non-Latino Whites while the incidence of gliosarcoma is similar. Despite lower rates of radiation therapy and greater rates of sub-total resection than non-Latino Whites, Latinos have better 1 and 5 year survival rates. SEER does not record chemotherapy data. Survivals of Latino sub-populations are similar with each other. Age, extent of resection, and the use of radiation therapy are associated with improved survival but none of these variables are sufficient in a multivariate analysis to explain the improved survival of Latinos relative to non-Latino Whites. As molecular data is not available in SEER records, we studied the MGMT and IDH status of 571 patients from a UCLA database. MGMT methylation and IDH1 mutation rates are not statistically significantly different between non-Latino Whites and Latinos. For UCLA patients with available information, chemotherapy and radiation rates are similar for non-Latino White and Latino patients, but the latter have lower rates of gross total resection and present at a younger age.
Literatur
2.
Zurück zum Zitat CBTRUS (2012), CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2008 (March 23, 2012 Revision). Source: central brain tumor registry of the United States, Hinsdale, IL CBTRUS (2012), CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2008 (March 23, 2012 Revision). Source: central brain tumor registry of the United States, Hinsdale, IL
3.
Zurück zum Zitat Braganza MZ, Kitahara CM, de González AB et al (2012) Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review. Neuro Oncol 14(11):1316–1324CrossRef Braganza MZ, Kitahara CM, de González AB et al (2012) Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review. Neuro Oncol 14(11):1316–1324CrossRef
4.
Zurück zum Zitat Neglia JP, Robison LL, Stovall M et al (2006) New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Inst 98(21):1528–1537CrossRef Neglia JP, Robison LL, Stovall M et al (2006) New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Inst 98(21):1528–1537CrossRef
5.
Zurück zum Zitat Krishnan G, Felini M, Carozza SE et al (2003) Occupation and adult gliomas in the San Francisco bay area. J Occup Environ Med 45(6):639–647CrossRef Krishnan G, Felini M, Carozza SE et al (2003) Occupation and adult gliomas in the San Francisco bay area. J Occup Environ Med 45(6):639–647CrossRef
6.
Zurück zum Zitat Savitz DA, Loomis DP (1995) Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141(2):123–134CrossRef Savitz DA, Loomis DP (1995) Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141(2):123–134CrossRef
7.
Zurück zum Zitat Greig NH, Ries LG, Yancik R et al (1990) Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 82(20):1621–1624CrossRef Greig NH, Ries LG, Yancik R et al (1990) Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 82(20):1621–1624CrossRef
8.
Zurück zum Zitat Hess KR, Broglio KR, Bondy ML (2004) Adult glioma incidence trends in the United States, 1977–2000. Cancer 101(10):2293–2299CrossRef Hess KR, Broglio KR, Bondy ML (2004) Adult glioma incidence trends in the United States, 1977–2000. Cancer 101(10):2293–2299CrossRef
9.
Zurück zum Zitat Chandler KL, Prados MD, Malec M et al (1993) Long-term survival in patients with glioblastoma multiforme. Neurosurgery 32(5):716–720CrossRef Chandler KL, Prados MD, Malec M et al (1993) Long-term survival in patients with glioblastoma multiforme. Neurosurgery 32(5):716–720CrossRef
10.
Zurück zum Zitat Müller H, Brock M, Ernst H (1985) Long-term survival and recurrence-free interval in combined surgical, radio and chemotherapy of malignant brain gliomas. Clin Neurol Neurosurg 87(3):167–171CrossRef Müller H, Brock M, Ernst H (1985) Long-term survival and recurrence-free interval in combined surgical, radio and chemotherapy of malignant brain gliomas. Clin Neurol Neurosurg 87(3):167–171CrossRef
11.
Zurück zum Zitat Salford LG, Brun A, Nirfalk S (1988) Ten-year survival among patients with supratentorial astrocytomas grade III and IV. J Neurosurg 69(4):506–509CrossRef Salford LG, Brun A, Nirfalk S (1988) Ten-year survival among patients with supratentorial astrocytomas grade III and IV. J Neurosurg 69(4):506–509CrossRef
12.
Zurück zum Zitat Thumma SR, Fairbanks RK, Lamoreaux WT et al (2012) Effect of pretreatment clinical factors on overall survival in glioblastoma multiforme: A surveillance epidemiology and end results (SEER) population analysis. World J Surg Oncol 10:75CrossRef Thumma SR, Fairbanks RK, Lamoreaux WT et al (2012) Effect of pretreatment clinical factors on overall survival in glioblastoma multiforme: A surveillance epidemiology and end results (SEER) population analysis. World J Surg Oncol 10:75CrossRef
13.
Zurück zum Zitat Stupp R, Hegi ME, Mason WP et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466CrossRef Stupp R, Hegi ME, Mason WP et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466CrossRef
15.
Zurück zum Zitat Kamoshima Y, Motegi H, Terasaka S et al (2012) Analyses of IDH1 mutation and MGMT promoter methylation status for 5 cases of long-term survivors with glioblastoma. No Shinkei Geka 40(2):129–135PubMed Kamoshima Y, Motegi H, Terasaka S et al (2012) Analyses of IDH1 mutation and MGMT promoter methylation status for 5 cases of long-term survivors with glioblastoma. No Shinkei Geka 40(2):129–135PubMed
16.
Zurück zum Zitat Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997–1003CrossRef Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997–1003CrossRef
17.
Zurück zum Zitat Preston-Martin S (1989) Descriptive epidemiology of primary tumors of the brain cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 8(6):283–295CrossRef Preston-Martin S (1989) Descriptive epidemiology of primary tumors of the brain cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 8(6):283–295CrossRef
18.
Zurück zum Zitat Robertson JT, Gunter BC, Somes GW (2002) Racial differences in the incidence of gliomas: a retrospective study from Memphis, Tennessee. Br J Neurosurg 16(6):562–566CrossRef Robertson JT, Gunter BC, Somes GW (2002) Racial differences in the incidence of gliomas: a retrospective study from Memphis, Tennessee. Br J Neurosurg 16(6):562–566CrossRef
19.
Zurück zum Zitat Barnholtz-Sloan JS, Maldonado JL, Williams VL et al (2007) Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neuro-Oncol 85(2):171–180CrossRef Barnholtz-Sloan JS, Maldonado JL, Williams VL et al (2007) Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neuro-Oncol 85(2):171–180CrossRef
20.
Zurück zum Zitat Deorah S, Lynch CF, Sibenaller ZA et al (2006) Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20(4):E1CrossRef Deorah S, Lynch CF, Sibenaller ZA et al (2006) Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20(4):E1CrossRef
21.
Zurück zum Zitat Chakrabarti I, Cockburn M, Cozen W et al (2005) A population-based description of glioblastoma multiforme in Los Angeles County, 1974–1999. Cancer 104(12):2798–2806CrossRef Chakrabarti I, Cockburn M, Cozen W et al (2005) A population-based description of glioblastoma multiforme in Los Angeles County, 1974–1999. Cancer 104(12):2798–2806CrossRef
22.
Zurück zum Zitat Colby SL, Ortman JM (2015) Projections of the size and composition of the U.S. population: 2014 to 2060 population, estimates and projections current population: U.S. department of commerce economics and statistics administration, U.S. census bureau, census.gov, P25–1143 Colby SL, Ortman JM (2015) Projections of the size and composition of the U.S. population: 2014 to 2060 population, estimates and projections current population: U.S. department of commerce economics and statistics administration, U.S. census bureau, census.gov, P25–1143
23.
Zurück zum Zitat Curry WT Jr, Barker FG 2nd (2009) Racial, ethnic and socioeconomic disparities in the treatment of brain tumors. J Neurooncol 93(1):25–39CrossRef Curry WT Jr, Barker FG 2nd (2009) Racial, ethnic and socioeconomic disparities in the treatment of brain tumors. J Neurooncol 93(1):25–39CrossRef
24.
Zurück zum Zitat Murthy VH, Krumholz HM (2004) Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 291(22):2720–2726CrossRef Murthy VH, Krumholz HM (2004) Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 291(22):2720–2726CrossRef
25.
Zurück zum Zitat NAACCR Race and Ethnicity Work Group. (2009) NAACCR guideline for enhancing hispanic/latino identification: revised NAACCR hispanic/latino identification algorithm [NHIA v2.2]. North American Association of Central Cancer Registries, Springfield NAACCR Race and Ethnicity Work Group. (2009) NAACCR guideline for enhancing hispanic/latino identification: revised NAACCR hispanic/latino identification algorithm [NHIA v2.2]. North American Association of Central Cancer Registries, Springfield
26.
Zurück zum Zitat McLendon RE, Robinson JS Jr, Chambers DB et al (1985) The glioblastoma multiforme in Georgia, 1977–1981. Cancer 56(4):894–897CrossRef McLendon RE, Robinson JS Jr, Chambers DB et al (1985) The glioblastoma multiforme in Georgia, 1977–1981. Cancer 56(4):894–897CrossRef
27.
Zurück zum Zitat Barnholtz-Sloan JS, Sloan AE, Schwartz AG (2003) Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973–1997. J Neurosurg 99(3):458–466CrossRef Barnholtz-Sloan JS, Sloan AE, Schwartz AG (2003) Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973–1997. J Neurosurg 99(3):458–466CrossRef
28.
Zurück zum Zitat Dubrow R, Darefsky AS (2011) Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007. BMC Cancer 11:325CrossRef Dubrow R, Darefsky AS (2011) Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007. BMC Cancer 11:325CrossRef
29.
Zurück zum Zitat Brown M, Schrot R, Bauer K et al (2009) Incidence of first primary central nervous system tumors in California, 2001–2005: children, adolescents and teens. J Neuro-Oncol 94(2):263–273CrossRef Brown M, Schrot R, Bauer K et al (2009) Incidence of first primary central nervous system tumors in California, 2001–2005: children, adolescents and teens. J Neuro-Oncol 94(2):263–273CrossRef
30.
Zurück zum Zitat Koshy M, Villano JL, Dolecek TA et al (2012) Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neuroonco 107(1): 207–212CrossRef Koshy M, Villano JL, Dolecek TA et al (2012) Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neuroonco 107(1): 207–212CrossRef
31.
Zurück zum Zitat Burger PC, Green SB (1987) Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59(9):1617–1625CrossRef Burger PC, Green SB (1987) Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59(9):1617–1625CrossRef
32.
Zurück zum Zitat Sneed PK, Prados MD, McDermott MW et al (1995) Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost. Neurosurgery 36(5):898–903CrossRef Sneed PK, Prados MD, McDermott MW et al (1995) Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost. Neurosurgery 36(5):898–903CrossRef
33.
Zurück zum Zitat Krex D, Klink B, Hartmann C et al (2007) Long-term survival with glioblastoma multiforme. Brain 130(Pt 10):2596–2606CrossRef Krex D, Klink B, Hartmann C et al (2007) Long-term survival with glioblastoma multiforme. Brain 130(Pt 10):2596–2606CrossRef
34.
Zurück zum Zitat Laws ER, Parney IF, Huang W et al (2003) Glioma outcomes investigators. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the glioma outcomes project. J Neurosurg 99(3):467–473CrossRef Laws ER, Parney IF, Huang W et al (2003) Glioma outcomes investigators. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the glioma outcomes project. J Neurosurg 99(3):467–473CrossRef
35.
Zurück zum Zitat Simpson JR, Horton J, Scott C et al (1993) Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26(2):239–244CrossRef Simpson JR, Horton J, Scott C et al (1993) Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 26(2):239–244CrossRef
36.
Zurück zum Zitat Lacroix M, Abi-Said D, Fourney DR et al (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):1908CrossRef Lacroix M, Abi-Said D, Fourney DR et al (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):1908CrossRef
37.
Zurück zum Zitat Singal V, Singal AK, Kuo YF (2012) Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis. J Cancer Res Clin Oncol 138(4):715–722CrossRef Singal V, Singal AK, Kuo YF (2012) Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis. J Cancer Res Clin Oncol 138(4):715–722CrossRef
38.
Zurück zum Zitat McCann J, Artinian V, Duhaime L et al (2005) Evaluation of the causes for racial disparity in surgical treatment of early stage lung cancer. Chest 128(5):3440–3446CrossRef McCann J, Artinian V, Duhaime L et al (2005) Evaluation of the causes for racial disparity in surgical treatment of early stage lung cancer. Chest 128(5):3440–3446CrossRef
39.
Zurück zum Zitat Terplan M, Schluterman N, McNamara EJ et al (2012) Have racial disparities in ovarian cancer increased over time? An analysis of SEER data. Gynecol Oncol 125(1):19–24CrossRef Terplan M, Schluterman N, McNamara EJ et al (2012) Have racial disparities in ovarian cancer increased over time? An analysis of SEER data. Gynecol Oncol 125(1):19–24CrossRef
40.
Zurück zum Zitat Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5(10):1725–1731CrossRef Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5(10):1725–1731CrossRef
41.
Zurück zum Zitat Stupp R, Dietrich PY, Kraljevic SO et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20(5):1375–1382CrossRef Stupp R, Dietrich PY, Kraljevic SO et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20(5):1375–1382CrossRef
42.
Zurück zum Zitat Aizer AA, Ancukiewicz M, Nguyen PL et al (2014) Underutilization of radiation therapy in patients with glioblastoma: predictive factors and outcomes. Cancer 120(2):238–243CrossRef Aizer AA, Ancukiewicz M, Nguyen PL et al (2014) Underutilization of radiation therapy in patients with glioblastoma: predictive factors and outcomes. Cancer 120(2):238–243CrossRef
43.
Zurück zum Zitat Walker GV, Li J, Mahajan A et al (2012) Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme: a population-based analysis. Cancer 118(18):4538–4544CrossRef Walker GV, Li J, Mahajan A et al (2012) Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme: a population-based analysis. Cancer 118(18):4538–4544CrossRef
44.
Zurück zum Zitat Punglia RS, Weeks JC, Neville BA et al (2006) Effect of distance to radiation treatment facility on use of radiation therapy after mastectomy in elderly women. Int J Radiat Oncol Biol Phys 66(1):56–63CrossRef Punglia RS, Weeks JC, Neville BA et al (2006) Effect of distance to radiation treatment facility on use of radiation therapy after mastectomy in elderly women. Int J Radiat Oncol Biol Phys 66(1):56–63CrossRef
45.
Zurück zum Zitat Bradley CJ, Given CW, Roberts C (2002) Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst 94(7):490–496CrossRef Bradley CJ, Given CW, Roberts C (2002) Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst 94(7):490–496CrossRef
46.
Zurück zum Zitat Kozak KR, Moody JS (2009) Giant cell glioblastoma: a glioblastoma subtype with distinct epidemiology and superior prognosis. Neuro Oncol 11(6):833–841CrossRef Kozak KR, Moody JS (2009) Giant cell glioblastoma: a glioblastoma subtype with distinct epidemiology and superior prognosis. Neuro Oncol 11(6):833–841CrossRef
48.
Zurück zum Zitat Lopez-Gonzalez MA, Sotelo J (2000) Brain tumors in Mexico: characteristics and prognosis of glioblastoma. Surg Neurol 53(2):157–162CrossRef Lopez-Gonzalez MA, Sotelo J (2000) Brain tumors in Mexico: characteristics and prognosis of glioblastoma. Surg Neurol 53(2):157–162CrossRef
Metadaten
Titel
Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma
verfasst von
Maryam Shabihkhani
Donatello Telesca
Masoud Movassaghi
Yalda B. Naeini
Kourosh M. Naeini
Seyed Amin Hojat
Diviya Gupta
Gregory M. Lucey
Michael Ontiveros
Michael W. Wang
Lauren S. Hanna
Desiree E. Sanchez
Sergey Mareninov
Negar Khanlou
Harry V. Vinters
Marvin Bergsneider
Phioanh Leia Nghiemphu
Albert Lai
Linda M. Liau
Timothy F. Cloughesy
William H. Yong
Publikationsdatum
04.02.2017
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 2/2017
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-017-2377-0

Weitere Artikel der Ausgabe 2/2017

Journal of Neuro-Oncology 2/2017 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.