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Erschienen in: Virchows Archiv 3/2019

02.05.2019 | Original Article

Incidental lymphoma in lymph node dissection for carcinoma in the abdominopelvic cavity: a single-institution experience

verfasst von: Yuhua Huang, Shumei Yan, Lili Liu, Jiabin Lu, Xia Yang, Yangfan He, Jingping Yun

Erschienen in: Virchows Archiv | Ausgabe 3/2019

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Abstract

Incidental detection of lymphoma in lymph node (LN) dissection for carcinoma is extremely rare. The occurrence and clinicopathological features of this rare condition have not been characterised. The medical records of 11,889 consecutive patients who underwent LN dissection for carcinoma in the abdominopelvic cavity were retrospectively reviewed. Among these patients, 11 had lymphomas detected in LN dissections and 7 had no previous history of lymphoma, representing an incidental detection rate of 0.06% (7/11889). The patients had a median age of 63 years (range, 48–69 years), and the male-to-female ratio was 1:2.5. The sites and histological types of the carcinoma were as follows: adenocarcinoma of the sigmoid colon (2 cases), endometrioid adenocarcinoma of the endometrium (2 cases), squamous carcinoma of the uterine cervix (1 case), adenocarcinoma of the stomach (1 case), and adenocarcinoma of the rectum (1 case). All incidental lymphoma cases (100%, 7/7) were low-grade B cell non-Hodgkin lymphoma (B-NHL), including 5 cases of follicular lymphoma (grades 1–2) and 2 cases of small lymphocytic lymphoma. The median follow-up interval was 39 months (5–65 months). All the patients were alive at the end of the follow-up period. Low-grade B-NHL can be incidentally detected during LN dissection for carcinoma in the abdominopelvic cavity. The subtype of incidental lymphoma is likely related to the epidemiology of lymphoma classes in the corresponding area. We should be aware of simultaneous occurrence of incidental lymphoma during lymphadenectomy for carcinoma.
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Literatur
1.
Zurück zum Zitat Sun Y, Shi YF, Zhou LX, Chen KN, Li XH (2011) Synchronous pulmonary squamous cell carcinoma and mantle cell lymphoma of the lymph node. Case Rep Genet 2011:945181PubMedPubMedCentral Sun Y, Shi YF, Zhou LX, Chen KN, Li XH (2011) Synchronous pulmonary squamous cell carcinoma and mantle cell lymphoma of the lymph node. Case Rep Genet 2011:945181PubMedPubMedCentral
2.
Zurück zum Zitat Habermann W, Anderhuber W, Humer-Fuchs U, Stammberger H (1997) Simultaneous occurrence of metastatic tonsillar squamous cell carcinoma and angioimmunoblastic T-cell lymphoma in a cervical lymph node. J Laryngol Otol 111:580–582CrossRefPubMed Habermann W, Anderhuber W, Humer-Fuchs U, Stammberger H (1997) Simultaneous occurrence of metastatic tonsillar squamous cell carcinoma and angioimmunoblastic T-cell lymphoma in a cervical lymph node. J Laryngol Otol 111:580–582CrossRefPubMed
3.
Zurück zum Zitat Tihan T, Filippa DA (1996) Coexistence of renal cell carcinoma and malignant lymphoma. A causal relationship or coincidental occurrence. Cancer 77:2325–2331CrossRefPubMed Tihan T, Filippa DA (1996) Coexistence of renal cell carcinoma and malignant lymphoma. A causal relationship or coincidental occurrence. Cancer 77:2325–2331CrossRefPubMed
4.
Zurück zum Zitat Travis LB, Curtis RE, Boice JD, Hankey BF, Fraumeni JF (1991) Second cancers following non-Hodgkin’s lymphoma. Cancer 67:2002–2009CrossRefPubMed Travis LB, Curtis RE, Boice JD, Hankey BF, Fraumeni JF (1991) Second cancers following non-Hodgkin’s lymphoma. Cancer 67:2002–2009CrossRefPubMed
5.
Zurück zum Zitat Ellis M, Lishner M (1993) Second malignancies following treatment in non-Hodgkin’s lymphoma. Leuk Lymphoma 9:337–342CrossRefPubMed Ellis M, Lishner M (1993) Second malignancies following treatment in non-Hodgkin’s lymphoma. Leuk Lymphoma 9:337–342CrossRefPubMed
6.
Zurück zum Zitat Zabrocka E, Sierko E, Jelski S, Wojtukiewicz MZ (2016) Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: a case report. Mol Clin Oncol 5:455–457CrossRefPubMedPubMedCentral Zabrocka E, Sierko E, Jelski S, Wojtukiewicz MZ (2016) Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: a case report. Mol Clin Oncol 5:455–457CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Miles EF, Jacimore LL (2012) Synchronous bilateral breast carcinoma and axillary non-Hodgkin lymphoma: a case report and review of the literature. Case Rep Oncol Med 2012:685919PubMedPubMedCentral Miles EF, Jacimore LL (2012) Synchronous bilateral breast carcinoma and axillary non-Hodgkin lymphoma: a case report and review of the literature. Case Rep Oncol Med 2012:685919PubMedPubMedCentral
8.
Zurück zum Zitat Xue L-J, Yang J-H, Su Q-S, Wang H, Liu C (2010) Synchronous gastric carcinoma and nodal malignant lymphoma: a rare case report and literature review. Case Rep Oncol 3:223–230CrossRefPubMedPubMedCentral Xue L-J, Yang J-H, Su Q-S, Wang H, Liu C (2010) Synchronous gastric carcinoma and nodal malignant lymphoma: a rare case report and literature review. Case Rep Oncol 3:223–230CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Eisenberger CF, Walsh PC, Eisenberger MA, Chow NH, Partin AW, Mostwin JL, Marshall FF, Epstein JI, Schoenberg M (1999) Incidental non-Hodgkin’s lymphoma in patients with localized prostate cancer. Urology 53:175–179CrossRefPubMed Eisenberger CF, Walsh PC, Eisenberger MA, Chow NH, Partin AW, Mostwin JL, Marshall FF, Epstein JI, Schoenberg M (1999) Incidental non-Hodgkin’s lymphoma in patients with localized prostate cancer. Urology 53:175–179CrossRefPubMed
10.
Zurück zum Zitat Fernandez-Pello S, Rodriguez Villamil L, Gonzalez Rodriguez I, Venta V, Cuervo J, Menendez CL (2013) Lymph node non-Hodgkin’s lymphoma incidentally discovered during a nephrectomy for renal cell carcinoma. World J Clin Cases 1:121–123CrossRefPubMedPubMedCentral Fernandez-Pello S, Rodriguez Villamil L, Gonzalez Rodriguez I, Venta V, Cuervo J, Menendez CL (2013) Lymph node non-Hodgkin’s lymphoma incidentally discovered during a nephrectomy for renal cell carcinoma. World J Clin Cases 1:121–123CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Steven H, Swerdlow EC, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (2017) Who classification of tumours of haematopoietic and lymphoid tissues Revised 4th edition. IARC, Lyon, pp 199–464 Steven H, Swerdlow EC, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (2017) Who classification of tumours of haematopoietic and lymphoid tissues Revised 4th edition. IARC, Lyon, pp 199–464
12.
Zurück zum Zitat Huang Y, Xie J, Ding Y, Zhou X (2016) Extranodal natural killer/T-cell lymphoma in children and adolescents: a report of 17 cases in China. Am J Clin Pathol 145:46–54CrossRefPubMed Huang Y, Xie J, Ding Y, Zhou X (2016) Extranodal natural killer/T-cell lymphoma in children and adolescents: a report of 17 cases in China. Am J Clin Pathol 145:46–54CrossRefPubMed
13.
Zurück zum Zitat Langerak AW, Groenen PJ, Brüggemann M, Beldjord K, Bellan C, Bonello L, Boone E, Carter GI, Catherwood M, Davi F, Delfau-Larue MH, Diss T, Evans PA, Gameiro P, Garcia Sanz R, Gonzalez D, Grand D, Håkansson A, Hummel M, Liu H, Lombardia L, Macintyre EA, Milner BJ, Montes-Moreno S, Schuuring E, Spaargaren M, Hodges E, van Dongen JJ (2012) Euroclonality/biomed-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 26:2159–2171CrossRefPubMedPubMedCentral Langerak AW, Groenen PJ, Brüggemann M, Beldjord K, Bellan C, Bonello L, Boone E, Carter GI, Catherwood M, Davi F, Delfau-Larue MH, Diss T, Evans PA, Gameiro P, Garcia Sanz R, Gonzalez D, Grand D, Håkansson A, Hummel M, Liu H, Lombardia L, Macintyre EA, Milner BJ, Montes-Moreno S, Schuuring E, Spaargaren M, Hodges E, van Dongen JJ (2012) Euroclonality/biomed-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 26:2159–2171CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Murakami T, Shoji T, Suzuki K, Ishikawa S, Maruo H (2014) Simultaneous occurrence of early gastric carcinoma and mucosa-associated lymphoid tissue lymphoma of the omentum. Case Rep Gastroenterol 8:101–106CrossRefPubMedPubMedCentral Murakami T, Shoji T, Suzuki K, Ishikawa S, Maruo H (2014) Simultaneous occurrence of early gastric carcinoma and mucosa-associated lymphoid tissue lymphoma of the omentum. Case Rep Gastroenterol 8:101–106CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Ozimek A, Diebold J, Linke R, Heyn J, Hallfeldt K, Mussack T (2008) Bilateral primary adrenal non-Hodgkin’s lymphoma and primary adrenocortical carcinoma–review of the literature preoperative differentiation of adrenal tumors 55 (4):625–638 Ozimek A, Diebold J, Linke R, Heyn J, Hallfeldt K, Mussack T (2008) Bilateral primary adrenal non-Hodgkin’s lymphoma and primary adrenocortical carcinoma–review of the literature preoperative differentiation of adrenal tumors 55 (4):625–638
16.
Zurück zum Zitat Kobayashi YAH, Watanabe S (1990) Second malignant lymphomas and leukemias in the national cancer center from 1962 to 1987. Jpn J Cancer Res 81:7CrossRef Kobayashi YAH, Watanabe S (1990) Second malignant lymphomas and leukemias in the national cancer center from 1962 to 1987. Jpn J Cancer Res 81:7CrossRef
17.
Zurück zum Zitat Beisland C, Talleraas O, Bakke A, Norstein J (2006) Multiple primary malignancies in patients with renal cell carcinoma: a national population-based cohort study. BJU Int 97:698–702CrossRefPubMed Beisland C, Talleraas O, Bakke A, Norstein J (2006) Multiple primary malignancies in patients with renal cell carcinoma: a national population-based cohort study. BJU Int 97:698–702CrossRefPubMed
18.
Zurück zum Zitat Kamiyama Y, Kobayashi Y, Fukuhara S, Morikawa N, Munakata W, Miyagi Maeshima A, Maruyama D, Kim SW, Watanabe T, Terauchi T, Muramatsu Y, Tobinai K (2015) Incidental detection of malignant lymphoma in subjects in a cancer surveillance programme. Br J Haematol 169:138–142CrossRefPubMed Kamiyama Y, Kobayashi Y, Fukuhara S, Morikawa N, Munakata W, Miyagi Maeshima A, Maruyama D, Kim SW, Watanabe T, Terauchi T, Muramatsu Y, Tobinai K (2015) Incidental detection of malignant lymphoma in subjects in a cancer surveillance programme. Br J Haematol 169:138–142CrossRefPubMed
19.
Zurück zum Zitat Yang QP, Zhang WY, Yu JB, Zhao S, Xu H, Wang WY, Bi CF, Zuo Z, Wang XQ, Huang J, Dai L, Liu WP (2011) Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution. Diagn Pathol 6:77CrossRefPubMedPubMedCentral Yang QP, Zhang WY, Yu JB, Zhao S, Xu H, Wang WY, Bi CF, Zuo Z, Wang XQ, Huang J, Dai L, Liu WP (2011) Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution. Diagn Pathol 6:77CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 311:1471–1475CrossRefPubMed Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 311:1471–1475CrossRefPubMed
21.
Zurück zum Zitat Bermudez G, González de Villambrosía S, Martínez-López A, Batlle A, Revert-Arce JB, Cereceda Company L, Ortega Bezanilla C, Piris MA, Montes-Moreno S (2016) Incidental and isolated follicular lymphoma in situ and mantle cell lymphoma in situ lack clinical significance. Am J Surg Pathol 40(7):943–949CrossRefPubMed Bermudez G, González de Villambrosía S, Martínez-López A, Batlle A, Revert-Arce JB, Cereceda Company L, Ortega Bezanilla C, Piris MA, Montes-Moreno S (2016) Incidental and isolated follicular lymphoma in situ and mantle cell lymphoma in situ lack clinical significance. Am J Surg Pathol 40(7):943–949CrossRefPubMed
22.
Zurück zum Zitat Henopp T, Quintanilla-Martínez L, Fend F, Adam P (2011) Prevalence of follicular lymphoma in situ in consecutively analysed reactive lymph nodes. Histopathology 59(1):139–142CrossRefPubMed Henopp T, Quintanilla-Martínez L, Fend F, Adam P (2011) Prevalence of follicular lymphoma in situ in consecutively analysed reactive lymph nodes. Histopathology 59(1):139–142CrossRefPubMed
23.
Zurück zum Zitat Oishi N, Montes-Moreno S, Feldman AL (2018) In situ neoplasia in lymph node pathology. Semin Diagn Pathol 35(1):76–83CrossRefPubMed Oishi N, Montes-Moreno S, Feldman AL (2018) In situ neoplasia in lymph node pathology. Semin Diagn Pathol 35(1):76–83CrossRefPubMed
Metadaten
Titel
Incidental lymphoma in lymph node dissection for carcinoma in the abdominopelvic cavity: a single-institution experience
verfasst von
Yuhua Huang
Shumei Yan
Lili Liu
Jiabin Lu
Xia Yang
Yangfan He
Jingping Yun
Publikationsdatum
02.05.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 3/2019
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-019-02578-w

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