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09.11.2018 | Clinical Study

Incidentally found brain tumors in the pediatric population: a case series and proposed treatment algorithm

Zeitschrift:
Journal of Neuro-Oncology
Autoren:
Erin Wright, Ernest K. Amankwah, S. Parrish Winesett, Gerald F. Tuite, George Jallo, Carolyn Carey, Luis F. Rodriguez, Stacie Stapleton
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11060-018-03039-1) contains supplementary material, which is available to authorized users.

Abstract

Purpose

With the increasing use of imaging, there has been an increase in the number of incidentally found brain lesions in pediatric patients resulting in a treatment dilemma for physicians and emotional strain for patients and families. Adult studies support initial surveillance of incidentally found low grade appearing lesions as the most appropriate approach. The aim of this study was to evaluate incidental lesions in the pediatric population and propose an initial treatment algorithm for such lesions.

Methods

Pediatric records were retrospectively reviewed at Johns Hopkins All Children’s Hospital for incidentally found brain tumors between 2000 and 2017. Demographic data, presenting symptoms, treatment approach, and outcomes were reviewed for 55 patients, age 0–18.

Results

Of the 55 patients included in the study, 14 underwent surgical resection, 3 underwent biopsy, and 38 with benign imaging characteristics at presentation were monitored with radiology alone. Only one patient, out of the 17 that underwent resection or biopsy, had pathology consistent with a high grade glioma. Of the patients monitored radiographically 10 total patients showed an increase in the overall size of the lesion; however after a median follow up of 34.2 months only 2 increased to a degree that required surgical intervention.

Conclusions

The majority of incidentally found brain lesions with benign imaging characteristics at presentation may be managed conservatively. Surveillance is an important part of the initial management of incidental lesions in the pediatric population, but careful scrutiny must be paid to the potential for higher grade lesions or malignant transformation.

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Zusatzmaterial
Supplementary material 1 (XLSX 13 KB)
11060_2018_3039_MOESM1_ESM.xlsx
Literatur
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