nach oben

Erschienen in:

28.07.2017 | Original Article

Increase in echo intensity and extracellular-to-intracellular water ratio is independently associated with muscle weakness in elderly women

verfasst von: Masashi Taniguchi, Yosuke Yamada, Yoshihiro Fukumoto, Shinichiro Sawano, Seigo Minami, Tome Ikezoe, Yuya Watanabe, Misaka Kimura, Noriaki Ichihashi

Erschienen in: European Journal of Applied Physiology | Ausgabe 10/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The changes in muscle composition and its heterogeneity during aging are associated with muscle weakness in elderly persons independent of decreases in muscle mass or muscle thickness (MT). Both the assessment of echo intensity (EI) with ultrasound imaging and the evaluation of the extracellular water/intracellular water (ECW/ICW) ratio with segmental bioelectrical impedance spectroscopy (BIS) are non-invasive and convenient methods and seem valuable for muscle quality determination. However, no previous study has evaluated both EI and the ECW/ICW ratio simultaneously to investigate their relationship to muscle strength. The purpose of the present study was to investigate whether both EI and the ECW/ICW ratio are independently associated with muscle strength in elderly women.

Methods

A total of 179 elderly women with a mean age of 74.1 ± 4.9 years, living independently in the community, were enrolled. The MT and EI of the quadriceps femoris were measured using transverse ultrasound imaging. The ECW/ICW ratio in the upper thigh was calculated from segmental BIS. The maximum knee extensor strength and the presence of knee pain were also assessed.

Results

Knee extensor strength showed a significant positive correlation with MT, and significant negative correlations with EI, the ECW/ICW ratio, and age. Stepwise regression analysis revealed that knee extensor strength in elderly women was predicted by MT, EI, and the ECW/ICW ratio.

Conclusions

This study suggests that the simultaneous application of EI and the ECW/ICW ratio is useful in assessing muscle strength, and accurately estimates the changes in muscle quality related to muscle weakness.

Akima H, Hioki M, Yoshiko A, Koike T, Sakakibara H, Takahashi H, Oshida Y (2016) Intramuscular adipose tissue determined by T1-weighted MRI at 3T primarily reflects extramyocellular lipids. Magn Reson Imaging 34:397–403. doi:10.1016/j.mri.2015.12.038 CrossRefPubMed

Azzabou N, Hogrel JY, Carlier PG (2015) NMR based biomarkers to study age-related changes in the human quadriceps. Exp Gerontol 70:54–60. doi:10.1016/j.exger.2015.06.015 CrossRefPubMed

Cadore EL, Izquierdo M, Conceicao M, Radaelli R, Pinto RS, Baroni BM, Vaz MA, Alberton CL, Pinto SS, Cunha G, Bottaro M, Kruel LF (2012) Echo intensity is associated with skeletal muscle power and cardiovascular performance in elderly men. Exp Gerontol 47:473–478. doi:10.1016/j.exger.2012.04.002 CrossRefPubMed

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older People (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423. doi:10.1093/ageing/afq034 CrossRefPubMedPubMedCentral

Fukumoto Y, Ikezoe T, Tateuchi H, Tsukagoshi R, Akiyama H, So K, Kuroda Y, Yoneyama T, Ichihashi N (2012a) Muscle mass and composition of the hip, thigh and abdominal muscles in women with and without hip osteoarthritis. Ultrasound Med Biol 38:1540–1545. doi:10.1016/j.ultrasmedbio.2012.04.016 CrossRefPubMed

Fukumoto Y, Ikezoe T, Yamada Y, Tsukagoshi R, Nakamura M, Mori N, Kimura M, Ichihashi N (2012b) Skeletal muscle quality assessed from echo intensity is associated with muscle strength of middle-aged and elderly persons. Eur J Appl Physiol 112:1519–1525. doi:10.1007/s00421-011-2099-5 CrossRefPubMed

Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, Stamm E, Newman AB (2001) Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study. J Appl Physiol 90:2157–2165PubMed

Heckmatt JZ, Leeman S, Dubowitz V (1982) Ultrasound imaging in the diagnosis of muscle disease. J Pediatr 101:656–660CrossRefPubMed

Helme RD, Gibson SJ (2001) The epidemiology of pain in elderly people. Clin Geriatr Med 17:417–431CrossRefPubMed

Hirani V, Naganathan V, Blyth F, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG (2016) Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: the Concord Health and Ageing in Men Project. Age Ageing. doi:10.1093/ageing/afw214 PubMed

Janssen I, Heymsfield SB, Wang ZM, Ross R (2000) Skeletal muscle mass and distribution in 468 men and women aged 18–88 years. J Appl Physiol 89:81–88PubMed

Kaysen GA, Zhu F, Sarkar S, Heymsfield SB, Wong J, Kaitwatcharachai C, Kuhlmann MK, Levin NW (2005) Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy. Am J Clin Nutr 82:988–995PubMed

Kent-Braun JA, Ng AV, Young K (2000) Skeletal muscle contractile and noncontractile components in young and older women and men. J Appl Physiol 88:662–668PubMed

Klein CS, Rice CL, Marsh GD (2001) Normalized force, activation, and coactivation in the arm muscles of young and old men. J Appl Physiol 91:1341–1349PubMed

Kushner RF, Gudivaka R, Schoeller DA (1996) Clinical characteristics influencing bioelectrical impedance analysis measurements. Am J Clin Nutr 64:423S–427SPubMed

Liikavainio T, Lyytinen T, Tyrvainen E, Sipila S, Arokoski JP (2008) Physical function and properties of quadriceps femoris muscle in men with knee osteoarthritis. Arch Phys Med Rehabil 89:2185–2194. doi:10.1016/j.apmr.2008.04.012 CrossRefPubMed

Lopez P, Wilhelm EN, Rech A, Minozzo F, Radaelli R, Pinto RS (2017) Echo intensity independently predicts functionality in sedentary older men. Muscle Nerve 55:9–15. doi:10.1002/mus.25168 CrossRefPubMed

Oliviero A, Profice P, Tonali PA, Pilato F, Saturno E, Dileone M, Ranieri F, Di Lazzaro V (2006) Effects of aging on motor cortex excitability. Neurosci Res 55:74–77. doi:10.1016/j.neures.2006.02.002 CrossRefPubMed

Pillen S, Tak RO, Zwarts MJ, Lammens MM, Verrijp KN, Arts IM, van der Laak JA, Hoogerbrugge PM, van Engelen BG, Verrips A (2009) Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity. Ultrasound Med Biol 35:443–446. doi:10.1016/j.ultrasmedbio.2008.09.016 CrossRefPubMed

Radaelli R, Bottaro M, Wilhelm EN, Wagner DR, Pinto RS (2012) Time course of strength and echo intensity recovery after resistance exercise in women. J Strength Cond Res 26:2577–2584. doi:10.1519/JSC.0b013e31823dae96 CrossRefPubMed

Rantanen T, Guralnik JM, Ferrucci L, Penninx BW, Leveille S, Sipila S, Fried LP (2001) Coimpairments as predictors of severe walking disability in older women. J Am Geriatr Soc 49:21–27CrossRefPubMed

Rech A, Radaelli R, Goltz FR, da Rosa LH, Schneider CD, Pinto RS (2014) Echo intensity is negatively associated with functional capacity in older women. Age 36:9708. doi:10.1007/s11357-014-9708-2 CrossRefPubMedPubMedCentral

Reid KF, Pasha E, Doros G, Clark DJ, Patten C, Phillips EM, Frontera WR, Fielding RA (2014) Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties. Eur J Appl Physiol 114:29–39. doi:10.1007/s00421-013-2728-2 CrossRefPubMedPubMedCentral

Reimers K, Reimers CD, Wagner S, Paetzke I, Pongratz DE (1993) Skeletal muscle sonography: a correlative study of echogenicity and morphology. J Ultrasound Med 12:73–77CrossRefPubMed

Rice J, Keogh JWL (2009) Power training: can it improve functional performance in older adults? A systematic review. Int J Exerc Sci 2:131–151

Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127:990S–991SPubMed

Scott D, Blizzard L, Fell J, Jones G (2012) Prospective study of self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community-dwelling older adults. Arthritis Care Res (Hoboken) 64:30–37. doi:10.1002/acr.20545 CrossRef

Sipila S, Koskinen SOA, Taaffe DR, Takala TES, Cheng SL, Rantanen T, Toivanen J, Suominen H (2004) Determinants of lower-body muscle power in early postmenopausal women. J Am Geriatr Soc 52:939–944CrossRefPubMed

Skelton DA, Greig CA, Davies JM, Young A (1994) Strength, power and related functional ability of healthy people aged 65–89 years. Age Ageing 23:371–377CrossRefPubMed

Taniguchi M, Fukumoto Y, Kobayashi M, Kawasaki T, Maegawa S, Ibuki S, Ichihashi N (2015) Quantity and quality of the lower extremity muscles in women with knee osteoarthritis. Ultrasound Med Biol 41:2567–2574. doi:10.1016/j.ultrasmedbio.2015.05.014 CrossRefPubMed

Wilhelm EN, Rech A, Minozzo F, Radaelli R, Botton CE, Pinto RS (2014) Relationship between quadriceps femoris echo intensity, muscle power, and functional capacity of older men. Age 36:9625. doi:10.1007/s11357-014-9625-4 CrossRefPubMedPubMedCentral

Yamada Y, Schoeller DA, Nakamura E, Morimoto T, Kimura M, Oda S (2010) Extracellular water may mask actual muscle atrophy during aging. J Gerontol A Biol Sci Med Sci 65:510–516. doi:10.1093/gerona/glq001 CrossRefPubMed

Yamada Y, Watanabe Y, Ikenaga M, Yokoyama K, Yoshida T, Morimoto T, Kimura M (2013) Comparison of single- or multifrequency bioelectrical impedance analysis and spectroscopy for assessment of appendicular skeletal muscle in the elderly. J Appl Physiol 115:812–818. doi:10.1152/japplphysiol.00010.2013 CrossRefPubMed

Yamada Y, Matsuda K, Bjorkman MP, Kimura M (2014) Application of segmental bioelectrical impedance spectroscopy to the assessment of skeletal muscle cell mass in elderly men. Geriatr Gerontol Int 14:129–134. doi:10.1111/ggi.12212 CrossRefPubMed

Yamada Y, Buehring B, Krueger D, Anderson R, Schoeller D, Binkley N (2016a) Electrical properties assessed by segmental bioelectrical impedance spectroscopy as biomarkers of age-related loss of skeletal muscle quantity and quality. J Gerontol A Biol Sci Med Sci. doi:10.1093/gerona/glw125

Yamada Y, Yoshida T, Yokoyama K, Watanabe Y, Miyake M, Yamagata E, Yamada M, Kimura M, Kyoto-Kameoka S (2016b) The extracellular to intracellular water ratio in upper legs is negatively associated with skeletal muscle strength and gait speed in older people. J Gerontol A Biol Sci Med Sci. doi:10.1093/gerona/glw125

Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T (2009) Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab 27:620–628. doi:10.1007/s00774-009-0080-8 CrossRefPubMed

Zhu F, Schneditz D, Wang E, Levin NW (1998) Dynamics of segmental extracellular volumes during changes in body position by bioimpedance analysis. J Appl Physiol 85:497–504PubMed

Titel: Increase in echo intensity and extracellular-to-intracellular water ratio is independently associated with muscle weakness in elderly women
verfasst von: Masashi Taniguchi
Yosuke Yamada
Yoshihiro Fukumoto
Shinichiro Sawano
Seigo Minami
Tome Ikezoe
Yuya Watanabe
Misaka Kimura
Noriaki Ichihashi
Publikationsdatum: 28.07.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 10/2017
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-017-3686-x

Acute and chronic neuromuscular adaptations to local vibration training

Invited Review

Changing relative crank angle increases the metabolic cost of leg cycling

Original Article

Erratum to: Sitting position affects performance in cross-country sit-skiing

Erratum

Hypoxia affects tissue oxygenation differently in the thigh and calf muscles during incremental running

Original Article

Training and acute exercise modulates mitochondrial dynamics in football players’ blood mononuclear cells

Original Article

Early detection of exercise-induced muscle damage using elastography

Original Article

Neu im Fachgebiet Arbeitsmedizin

Schwangerschaftsabbrüche und Lebenslagen: Erkenntnisse auf Basis von pairfam-Daten

Open Access
Schwangerschaftsabbruch
Leitthema

Schwangerschaftsabbrüche nehmen in der öffentlichen Debatte großen Raum ein. Derzeit steht beispielsweise erneut die Strafbarkeit von Abbrüchen zur Diskussion, die bisher im Strafgesetzbuch in § 218 ff. geregelt ist. Eine von der Bundesregierung …

IQWiG-Evidenzbericht zum Thema psychische Folgen eines Schwangerschaftsabbruchs

Open Access
Schwangerschaftsabbruch
Leitthema

Das Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) wurde vom Bundesministerium für Gesundheit beauftragt, bei der Weiterentwicklung der S2k-Leitlinie „Schwangerschaftsabbruch im ersten Trimenon“ zu einer S3-Leitlinie zu …

Schwangerschaftsabbrüche in Deutschland – Ergebnisse der Bundesstatistik

Open Access
Schwangerschaftsabbruch
Leitthema

Nach einem Rückgang der Zahl der Schwangerschaftsabbrüche von ungefähr 130.000 jährlichen Abbrüchen in den Jahren von 1996 bis 2004 auf ca. 100.000 Fälle ab 2013/2014 gab es zuletzt wieder einen gewissen Anstieg auf 106.000 Abbrüche in 2023. Der …

Innovationen in der Versorgung von Schwangerschaftsabbrüchen während der COVID-19-Pandemie in Deutschland, Frankreich und Großbritannien

Open Access
Schwangerschaftsabbruch
Leitthema

Die COVID-19-Pandemie hatte drastische Auswirkungen auf die Gesundheitssysteme vieler Länder. Zur Aufrechterhaltung der Versorgung mussten umgehend Lösungen gefunden werden, wobei sich auch das Potenzial ergab, Innovationen zu beschleunigen. So …

Springer Medizin

Increase in echo intensity and extracellular-to-intracellular water ratio is independently associated with muscle weakness in elderly women

Abstract

Purpose

Methods

Results

Conclusions

Weitere Artikel der Ausgabe 10/2017

Acute and chronic neuromuscular adaptations to local vibration training

Changing relative crank angle increases the metabolic cost of leg cycling

Erratum to: Sitting position affects performance in cross-country sit-skiing

Hypoxia affects tissue oxygenation differently in the thigh and calf muscles during incremental running

Training and acute exercise modulates mitochondrial dynamics in football players’ blood mononuclear cells

Early detection of exercise-induced muscle damage using elastography

Neu im Fachgebiet Arbeitsmedizin

Schwangerschaftsabbrüche und Lebenslagen: Erkenntnisse auf Basis von pairfam-Daten

IQWiG-Evidenzbericht zum Thema psychische Folgen eines Schwangerschaftsabbruchs

Schwangerschaftsabbrüche in Deutschland – Ergebnisse der Bundesstatistik

Innovationen in der Versorgung von Schwangerschaftsabbrüchen während der COVID-19-Pandemie in Deutschland, Frankreich und Großbritannien

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten