Introduction
Methods
Animals
Experimental protocol
Echocardiography
Blood and urine measurements
Hemodynamics and cardiac function
Histology
Cardiomyocyte function
Endothelial function
Statistical analysis
Results
Control rats
Group | Control | RD |
---|---|---|
N
| 5 | 5 |
BW (g) | 386 ± 7 | 249 ± 14a
|
Food intake (g/24 h) | 15 ± 4 | 19 ± 1 |
Water intake (ml/24 h) | 24 ± 3 | 26 ± 2 |
Urine production (g/24 h) | 15 ± 2 | 11 ± 1 |
HW/BW (mg/g) | 3.2 ± 0.2 | 4.5 ± 0.5a
|
Lung/BW (mg/g) | 3.3 ± 0.0 | 4.8 ± 0.2a
|
RKW/BW (mg/g) | 3.7 ± 0.1 | 3.7 ± 0.1 |
UPE (mg/24 h) | 28 ± 5 | 76 ± 19a
|
FGS (AU) | 0.4 ± 0.4 | 1.6 ± 0.4a
|
Plasma creat (mg/L) | 31 ± 1 | 25 ± 4 |
MAP (mmHg) | 89 ± 4 | 102 ± 3a
|
LVSP (mmHg) | 117 ± 5 | 131 ± 3a
|
LVEDP (mmHg) | 5.3 ± 2.4 | 6.2 ± 1.9 |
HR (beats/min) | 359 ± 18 | 364 ± 14 |
CVP (mmHg) | 1.2 ± 1.9 | 2.1 ± 1.7 |
RBF/KW (ml/min/g) | 6.0 ± 1.6 | 2.6 ± 0.6a
|
Hct (%) | 47.6 ± 0.4 | 44.2 ± 0.3a
|
Myocardial infarction
Group | Control | CD | RD | CRD |
---|---|---|---|---|
N
| 10 | 6 | 9 | 10 |
BW (g) | 482 ± 11 | 466 ± 14 | 340 ± 9b
| 342 ± 8b
|
Food intake (g/24 h) | 11 ± 2 | 13 ± 3 | 13 ± 1 | 11 ± 1 |
Water intake (ml/24 h) | 21 ± 1 | 26 ± 5 | 22 ± 1 | 22 ± 1 |
Urine production (g/24 h) | 15 ± 2 | 18 ± 3 | 13 ± 1 | 14 ± 1 |
Hct (%) | 47.8 ± 0.6 | 48.7 ± 1.0 | 45.0 ± 0.8b
| 45.7 ± 0.7b
|
Plasma [Na] (mmol/L) | 137 ± 1 | 138 ± 1 | 137 ± 0 | 136 ± 1 |
Plasma [K] (mmol/L) | 4.4 ± 0.2 | 4.7 ± 0.2 | 4.5 ± 0.1 | 4.7 ± 0.1 |
Plasma [Cl] (mmol/L) | 102 ± 1 | 103 ± 1 | 105 ± 1 | 104 ± 0 |
Urine [Na] (mmol/L) | 92 ± 17 | 123 ± 36 | 147 ± 11b
| 159 ± 22b
|
Urine [K] (mmol/L) | 115 ± 15 | 125 ± 23 | 153 ± 9b
| 152 ± 21b
|
Urine [Cl] (mmol/L) | 101 ± 20 | 136 ± 40 | 176 ± 13b
| 184 ± 25 |
RKW/BW (mg/g) | 3.7 ± 0.1 | 3.3 ± 0.1a
| 3.3 ± 0.1b
| 3.1 ± 0.1b
|
FGS (AU) | 2.4 ± 0.6 | 3.6 ± 1.2 | 22.4 ± 2.1b
| 12.1 ± 1.4b
|
Renal effects
Group | Control | CD | RD | CRD |
---|---|---|---|---|
N
| 10 | 6 | 9 | 10 |
HR (b/min) | 331 ± 14 | 336 ± 35 | 360 ± 28 | 416 ± 38 |
MAP (mmHg) | 94 ± 3 | 88 ± 4 | 107 ± 4b
| 84 ± 5a
|
LVSP (mmHg) | 128 ± 4 | 123 ± 8 | 134 ± 3 | 108 ± 2ac
|
+dP/dt (mmHg/s) | 9,091 ± 299 | 7,463 ± 375a
| 8,993 ± 318 | 8,452 ± 455a
|
−dP/dt (mmHg/s) | 7,463 ± 375 | 6,009 ± 432a
| 6,199 ± 513 | 4,377 ± 299ac
|
RBF/KW (ml/min.g) | 7.1 ± 0.8 | 6.7 ± 0.4 | 2.8 ± 0.7b
| 2.7 ± 0.5b
|
Cardiac effects
Effects on cardiac function
Effects on myofilament function
Effects on cardiac structure
Circulatory effects
Effect on blood
Group | Control | CD | RD | CRD |
---|---|---|---|---|
N
| 10 | 5 | 9 | 9 |
Hct (%) | 47.8 ± 0.6 | 48.7 ± 1.0 | 45.0 ± 0.8b
| 45.7 ± 0.7b
|
RBC (#.1012/l) | 9.4 ± 0.1 | 9.4 ± 0.1 | 7.9 ± 0.2b
| 7.8 ± 0.1b
|
WBC (#.1012/l) | 10.7 ± 0.8 | 8.7 ± 0.6a
| 2.2 ± 0.2b
| 2.3 ± 0.1b
|
Platelets (#.1012/l) | 739 ± 68 | 852 ± 49 | 887 ± 44 | 832 ± 40 |