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Clinical Rheumatology

Erschienen in:

01.02.2016 | Original Article

Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

verfasst von: Peng Wang, Shi-Yang Guan, Shu-Zhen Xu, Hong-Miao Li, Rui-Xue Leng, Xiang-Pei Li, Hai-Feng Pan

Erschienen in: Clinical Rheumatology | Ausgabe 2/2016

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Abstract

This study aims to derive a more precise estimation on carotid intima-media thickness (CIMT) level in patients with rheumatoid arthritis (RA) and related factors. Studies published from January 1, 1982 to December 31, 2014 in English, which comparing CIMT between RA group and control group were searched in PubMed, Embase, and Cochrane Library databases. Heterogeneity test was performed, and publication bias was evaluated. Stata software 12.0 was used to perform the meta-analysis. Two-thousand one hundred sixty-three articles were obtained after searching databases, and 47 studies were finally included in the meta-analysis. The result of the analysis in random effect model showed that RA group had significantly higher CIMT than control group, with the standardized mean difference (SMD) of 1.04 and 95% CI (0.81,1.27). To evaluate the stability of our results, sensitivity analyses were performed, and the results showed no significant change when any one study was excluded. Subgroup analyses showed that region, race, age, BMI, and disease duration were associated with CIMT in RA patients. In summary, CIMT in RA patients is thicker than healthy controls, and it is influenced by region, race, age, BMI, and disease duration.

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Titel: Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis
verfasst von: Peng Wang
Shi-Yang Guan
Shu-Zhen Xu
Hong-Miao Li
Rui-Xue Leng
Xiang-Pei Li
Hai-Feng Pan
Publikationsdatum: 01.02.2016
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 2/2016
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-015-3130-8

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