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Journal of Cancer Research and Clinical Oncology

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01.04.2012 | Original Paper

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

verfasst von: Songlin Piao, Shu Zhao, Fulin Guo, Jie Xue, Guodong Yao, Zhili Wei, Qi Huang, Yao Sun, Bin Zhang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2012

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Abstract

Purpose

The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.

Methods

We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC.

Results

Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P _CD147 = 0.031; P _MMP-9 = 0.020) and overall survival (OS) (P _CD147 = 0.044; P _MMP-9 = 0.013).

Conclusion

CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.

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Titel: Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma
verfasst von: Songlin Piao
Shu Zhao
Fulin Guo
Jie Xue
Guodong Yao
Zhili Wei
Qi Huang
Yao Sun
Bin Zhang
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2012
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-011-1142-6

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

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Purpose

Methods

Results

Conclusion

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Abstract

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Conclusion

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