Background
Methods
Patients and tissues
IER3 (low) | IER3 (high) |
P
| |
---|---|---|---|
Number of patients, no. % | 49(55.7) | 39(44.3) | |
Gender, no.% | 0.799 | ||
Female | 12(24.5) | 8(20.5) | |
Male | 37(75.5) | 31(79.5) | |
Age at Surgery, median(IQR) | 70(62–75) | 72(62–80) | 0.462 |
pT, no. % | 0.493 | ||
< =pT2 | 16(32.7) | 10(25.6) | |
> =pT3 | 33(67.3) | 29(74.4) | |
pN, no. % (n = 79) |
0.018
| ||
pN(−) | 33(76.7) | 18(50.0) | |
pN(+) | 10(23.3) | 18(50.0) | |
LVI, no. % | 0.284 | ||
LVI(−) | 31(63.3) | 20(51.3) | |
LVI(+) | 18(36.7) | 19(48.7) | |
PNI, no. % | 0.808 | ||
PNI(−) | 37(75.5) | 28(71.8) | |
PNI(+) | 12(24.5) | 11(28.2) | |
STSM, no. % | 0.781 | ||
margin(−) | 40(81.6) | 33(84.6) | |
margin(+) | 9(18.4) | 6(15.4) | |
Metastasis, no. % | 1.000 | ||
Mets(−) | 29(59.2) | 23(59.0) | |
Mets(+) | 20(40.8) | 16(41.0) |
Immunohistochemistry and Immunoreactive score
Statistics
Results
Protein expression of IER3 in BCa
High IER3 protein expression was an independent indicator of poor prognosis in BCa patients
Univariable | Multivariable | |||||
---|---|---|---|---|---|---|
Hazard Ratio | 95% CI |
P
| Hazard Ratio Ratio | 95% CI |
p
| |
Gender | ||||||
Male vs. Female | 1.14 | 0.62–2.10 | 0.681 | |||
Age | 1.03 | 1.00–1.05 |
0.029
| 1.04 | 1.01–1.07 |
0.012
|
pT | ||||||
> =pT3 vs. <=pT2 | 2.39 | 1.29–4.42 |
0.006
| 1.54 | 0.71–3.32 | 0.272 |
pN | ||||||
pN(+) vs. pN(−) | 3.41 | 1.95–5.99 |
< 0.001
| 2.35 | 1.26–4.38 |
0.007
|
LVI | ||||||
LVI(+) vs. LVI(−) | 2.03 | 1.22–3.37 |
0.006
| 0.99 | 0.52–1.89 | 0.987 |
PNI | ||||||
PNI(+) vs. PNI(−) | 1.03 | 0.56–1.87 | 0.935 | |||
STSM | ||||||
STSM(+) vs. STSM(−) | 2.62 | 1.41–4.88 |
0.002
| 2.02 | 0.96–4.27 | 0.065 |
Metastasis | ||||||
Mets(+) vs. Mets(−) | 2.35 | 1.41–3.97 |
0.001
| 1.81 | 0.98–3.33 | 0.058 |
IER3 IHC | ||||||
IER3(high) vs. IER3(low) | 2.16 | 1.29–3.13 |
0.003
| 2.21 | 1.21–4.04 |
0.010
|