Increased hepatic fatty acid polyunsaturation precedes ectopic lipid deposition in the liver in adaptation to high-fat diets in mice

Zurück zum Zitat Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, Gortmaker SL (2011) The global obesity pandemic: shaped by global drivers and local environments. Lancet 378(9793):804–814CrossRefPubMed Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, Gortmaker SL (2011) The global obesity pandemic: shaped by global drivers and local environments. Lancet 378(9793):804–814CrossRefPubMed

Zurück zum Zitat Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes H-P, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Uva MS, Taskinen M-R, Tendera M, Tuomilehto J, Valensi P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Erol Ç, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Torbicki A, Wijns W, Windecker S, De Backer G, Ezquerra EA, Avogaro A, Badimon L, Baranova E, Betteridge J, Ceriello A, Funck-Brentano C, Gulba DC, Hoes AW, Kjekshus JK, Lev E, Mueller C, Neyses L, Nilsson PM, Perk J, Reiner Ž, Sattar N, Schächinger V, Scheen A, Schirmer H, Strömberg A, Sudzhaeva S, Viigimaa M, Vlachopoulos C, Xuereb RG (2013) ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 34(39):3035–3087CrossRefPubMed Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes H-P, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Uva MS, Taskinen M-R, Tendera M, Tuomilehto J, Valensi P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Erol Ç, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Torbicki A, Wijns W, Windecker S, De Backer G, Ezquerra EA, Avogaro A, Badimon L, Baranova E, Betteridge J, Ceriello A, Funck-Brentano C, Gulba DC, Hoes AW, Kjekshus JK, Lev E, Mueller C, Neyses L, Nilsson PM, Perk J, Reiner Ž, Sattar N, Schächinger V, Scheen A, Schirmer H, Strömberg A, Sudzhaeva S, Viigimaa M, Vlachopoulos C, Xuereb RG (2013) ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 34(39):3035–3087CrossRefPubMed

Zurück zum Zitat Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M (2015) High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Am J Physiol Endocrinol Metab 308(7):E573–E582CrossRefPubMedPubMedCentral Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M (2015) High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Am J Physiol Endocrinol Metab 308(7):E573–E582CrossRefPubMedPubMedCentral

Zurück zum Zitat Gao X, Yan D, Zhao Y, Tao H, Zhou Y (2015) Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy. Nutr Metab 12:34CrossRef Gao X, Yan D, Zhao Y, Tao H, Zhou Y (2015) Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy. Nutr Metab 12:34CrossRef

Zurück zum Zitat van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PPH, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DPY, Heeringa P (2015) High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. Aging 7(4):256–267CrossRefPubMedPubMedCentral van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PPH, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DPY, Heeringa P (2015) High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. Aging 7(4):256–267CrossRefPubMedPubMedCentral

Zurück zum Zitat Gentile CL, Weir TL, Cox-York KA, Wei Y, Wang D, Reese L, Moran G, Estrada A, Mulligan C, Pagliassotti MJ, Foster MT (2015) The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD. Adipocyte 4(2):101–112CrossRefPubMedPubMedCentral Gentile CL, Weir TL, Cox-York KA, Wei Y, Wang D, Reese L, Moran G, Estrada A, Mulligan C, Pagliassotti MJ, Foster MT (2015) The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD. Adipocyte 4(2):101–112CrossRefPubMedPubMedCentral

Zurück zum Zitat Perry RJ, Samuel VT, Petersen KF, Shulman GI (2014) The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510(7503):84–91CrossRefPubMedPubMedCentral Perry RJ, Samuel VT, Petersen KF, Shulman GI (2014) The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510(7503):84–91CrossRefPubMedPubMedCentral

Zurück zum Zitat Wiedemann MSF, Wueest S, Item F, Schoenle EJ, Konrad D (2013) Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Am J Physiol Endocrinol Metab 305(3):E388–E395CrossRefPubMed Wiedemann MSF, Wueest S, Item F, Schoenle EJ, Konrad D (2013) Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Am J Physiol Endocrinol Metab 305(3):E388–E395CrossRefPubMed

Zurück zum Zitat Samuel VT, Liu Z-X, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279(31):32345–32353CrossRefPubMed Samuel VT, Liu Z-X, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279(31):32345–32353CrossRefPubMed

Zurück zum Zitat Boon Mariëtte R, Bakker Leontine EH, Haks Mariëlle C, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff Tom HM, Van Dijk KW, Guigas B, Jazet Ingrid M, Rensen Patrick CN (2014) Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects. Clin Sci 128(2):143–151CrossRef Boon Mariëtte R, Bakker Leontine EH, Haks Mariëlle C, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff Tom HM, Van Dijk KW, Guigas B, Jazet Ingrid M, Rensen Patrick CN (2014) Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects. Clin Sci 128(2):143–151CrossRef

Zurück zum Zitat Bakker LEH, van Schinkel LD, Guigas B, Streefland TCM, Jonker JT, van Klinken JB, van der Zon GCM, Lamb HJ, Smit JWA, Pijl H, Meinders AE, Jazet IM (2013) A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men. Diabetes 63(1):248–258CrossRef Bakker LEH, van Schinkel LD, Guigas B, Streefland TCM, Jonker JT, van Klinken JB, van der Zon GCM, Lamb HJ, Smit JWA, Pijl H, Meinders AE, Jazet IM (2013) A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men. Diabetes 63(1):248–258CrossRef

Zurück zum Zitat Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr (2007) Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 6(1):69–78CrossRefPubMed Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr (2007) Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 6(1):69–78CrossRefPubMed

Zurück zum Zitat Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L (2008) Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res 49(9):2038–2044CrossRefPubMedPubMedCentral Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L (2008) Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res 49(9):2038–2044CrossRefPubMedPubMedCentral

Zurück zum Zitat Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ (2016) Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice. Endocrinology 157(2):570–585CrossRefPubMed Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ (2016) Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice. Endocrinology 157(2):570–585CrossRefPubMed

Zurück zum Zitat Koonen DPY, Jacobs RL, Febbraio M, Young ME, Soltys C-LM, Ong H, Vance DE, Dyck JRB (2007) Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 56(12):2863–2871CrossRefPubMed Koonen DPY, Jacobs RL, Febbraio M, Young ME, Soltys C-LM, Ong H, Vance DE, Dyck JRB (2007) Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 56(12):2863–2871CrossRefPubMed

Zurück zum Zitat Brøns C, Jensen CB, Storgaard H, Hiscock NJ, White A, Appel JS, Jacobsen S, Nilsson E, Larsen CM, Astrup A, Quistorff B, Vaag A (2009) Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol 587(10):2387–2397CrossRefPubMedPubMedCentral Brøns C, Jensen CB, Storgaard H, Hiscock NJ, White A, Appel JS, Jacobsen S, Nilsson E, Larsen CM, Astrup A, Quistorff B, Vaag A (2009) Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol 587(10):2387–2397CrossRefPubMedPubMedCentral

Zurück zum Zitat Marks KA, Marvyn PM, Henao JJA, Bradley RM, Stark KD, Duncan RE (2015) Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose–liver axis in serum docosahexaenoic acid regulation. Genes Nutr 10(6):39CrossRefPubMedPubMedCentral Marks KA, Marvyn PM, Henao JJA, Bradley RM, Stark KD, Duncan RE (2015) Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose–liver axis in serum docosahexaenoic acid regulation. Genes Nutr 10(6):39CrossRefPubMedPubMedCentral

Zurück zum Zitat Heijboer AC, Donga E, Voshol PJ, Dang Z-C, Havekes LM, Romijn JA, Corssmit EPM (2005) Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. J Lipid Res 46(3):582–588CrossRefPubMed Heijboer AC, Donga E, Voshol PJ, Dang Z-C, Havekes LM, Romijn JA, Corssmit EPM (2005) Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. J Lipid Res 46(3):582–588CrossRefPubMed

Zurück zum Zitat Langhi C, Baldán Á (2015) CIDEC/Fsp27 is regulated by PPARα and plays a critical role in fasting- and diet-induced hepatosteatosis. Hepatology 61(4):1227–1238CrossRefPubMedPubMedCentral Langhi C, Baldán Á (2015) CIDEC/Fsp27 is regulated by PPARα and plays a critical role in fasting- and diet-induced hepatosteatosis. Hepatology 61(4):1227–1238CrossRefPubMedPubMedCentral

Zurück zum Zitat Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Schölmerich J, Bollheimer LC (2006) Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 36(3):485–501CrossRefPubMed Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Schölmerich J, Bollheimer LC (2006) Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 36(3):485–501CrossRefPubMed

Zurück zum Zitat Duivenvoorde LPM, van Schothorst EM, Swarts HM, Kuda O, Steenbergh E, Termeulen S, Kopecky J, Keijer J (2015) A difference in fatty acid composition of isocaloric high-fat diets alters metabolic flexibility in male C57BL/6JOlaHsd mice. PLoS ONE 10(6):e0128515CrossRefPubMedPubMedCentral Duivenvoorde LPM, van Schothorst EM, Swarts HM, Kuda O, Steenbergh E, Termeulen S, Kopecky J, Keijer J (2015) A difference in fatty acid composition of isocaloric high-fat diets alters metabolic flexibility in male C57BL/6JOlaHsd mice. PLoS ONE 10(6):e0128515CrossRefPubMedPubMedCentral

Zurück zum Zitat Nunes PM, Wright AJ, Veltien A, van Asten JJA, Tack CJ, Jones JG, Heerschap A (2014) Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose-compared to glucose-fed mice. FASEB J 28(5):1988–1997CrossRefPubMed Nunes PM, Wright AJ, Veltien A, van Asten JJA, Tack CJ, Jones JG, Heerschap A (2014) Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose-compared to glucose-fed mice. FASEB J 28(5):1988–1997CrossRefPubMed

Zurück zum Zitat Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Investig 115(5):1343–1351CrossRefPubMedPubMedCentral Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Investig 115(5):1343–1351CrossRefPubMedPubMedCentral

Zurück zum Zitat Jonkers RAM, Geraedts TR, van Loon LJC, Nicolay K, Prompers JJ (2012) Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy. Magn Reson Med 68(4):997–1006CrossRefPubMed Jonkers RAM, Geraedts TR, van Loon LJC, Nicolay K, Prompers JJ (2012) Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized ¹H-[¹³C] magnetic resonance spectroscopy. Magn Reson Med 68(4):997–1006CrossRefPubMed

Zurück zum Zitat Gruetter R, Tkáč I (2000) Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 43(2):319–323CrossRefPubMed Gruetter R, Tkáč I (2000) Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 43(2):319–323CrossRefPubMed

Zurück zum Zitat Soares AF, Lei H, Gruetter R (2015) Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time 1H-MRS at 14.1 T in vivo. NMR Biomed 28(8):1009–1020CrossRefPubMed Soares AF, Lei H, Gruetter R (2015) Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time ¹H-MRS at 14.1 T in vivo. NMR Biomed 28(8):1009–1020CrossRefPubMed

Zurück zum Zitat Tkáč I, Starčuk Z, Choi IY, Gruetter R (1999) In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 41(4):649–656CrossRefPubMed Tkáč I, Starčuk Z, Choi IY, Gruetter R (1999) In vivo ¹H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 41(4):649–656CrossRefPubMed

Zurück zum Zitat Ji Y, Sun S, Xia S, Yang L, Li X, Qi L (2012) Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J Biol Chem 287(29):24378–24386CrossRefPubMedPubMedCentral Ji Y, Sun S, Xia S, Yang L, Li X, Qi L (2012) Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J Biol Chem 287(29):24378–24386CrossRefPubMedPubMedCentral

Zurück zum Zitat Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB (2011) Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 60(10):2474–2483CrossRefPubMedPubMedCentral Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB (2011) Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 60(10):2474–2483CrossRefPubMedPubMedCentral

Zurück zum Zitat Williams LM, Campbell FM, Drew JE, Koch C, Hoggard N, Rees WD, Kamolrat T, Ngo HT, Steffensen I-L, Gray SR, Tups A (2014) The development of diet-induced obesity and glucose intolerance in C57Bl/6 mice on a high-fat diet consists of distinct phases. PLoS ONE 9(8):e106159CrossRefPubMedPubMedCentral Williams LM, Campbell FM, Drew JE, Koch C, Hoggard N, Rees WD, Kamolrat T, Ngo HT, Steffensen I-L, Gray SR, Tups A (2014) The development of diet-induced obesity and glucose intolerance in C57Bl/6 mice on a high-fat diet consists of distinct phases. PLoS ONE 9(8):e106159CrossRefPubMedPubMedCentral

Zurück zum Zitat Kowalski GM, Hamley S, Selathurai A, Kloehn J, De Souza DP, O’Callaghan S, Nijagal B, Tull DL, McConville MJ, Bruce CR (2016) Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis. Sci Rep 6:27541CrossRefPubMedPubMedCentral Kowalski GM, Hamley S, Selathurai A, Kloehn J, De Souza DP, O’Callaghan S, Nijagal B, Tull DL, McConville MJ, Bruce CR (2016) Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis. Sci Rep 6:27541CrossRefPubMedPubMedCentral

Zurück zum Zitat Duncan MJ, Smith JT, Narbaiza J, Mueez F, Bustle LB, Qureshi S, Fieseler C, Legan SJ (2016) Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet. Physiol Behav 167:1–9CrossRefPubMed Duncan MJ, Smith JT, Narbaiza J, Mueez F, Bustle LB, Qureshi S, Fieseler C, Legan SJ (2016) Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet. Physiol Behav 167:1–9CrossRefPubMed

Zurück zum Zitat Delgado TC, Barosa C, Nunes PM, Cerdán S, Geraldes CFGC, Jones JG (2012) Resolving the sources of plasma glucose excursions following a glucose tolerance test in the rat with deuterated water and [U-13C]glucose. PLoS ONE 7(3):e34042CrossRefPubMedPubMedCentral Delgado TC, Barosa C, Nunes PM, Cerdán S, Geraldes CFGC, Jones JG (2012) Resolving the sources of plasma glucose excursions following a glucose tolerance test in the rat with deuterated water and [U-¹³C]glucose. PLoS ONE 7(3):e34042CrossRefPubMedPubMedCentral

Zurück zum Zitat Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, Renn W, Gerich J (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23(3):295–301CrossRefPubMed Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, Renn W, Gerich J (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23(3):295–301CrossRefPubMed

Zurück zum Zitat Häring H-U (2016) Novel phenotypes of prediabetes? Diabetologia 59:1806–1818CrossRefPubMedPubMedCentral Häring H-U (2016) Novel phenotypes of prediabetes? Diabetologia 59:1806–1818CrossRefPubMedPubMedCentral

Zurück zum Zitat Seppälä-Lindroos A, Vehkavaara S, Häkkinen A-M, Goto T, Westerbacka J, Sovijärvi A, Halavaara J, Yki-Järvinen H (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87(7):3023–3028CrossRefPubMed Seppälä-Lindroos A, Vehkavaara S, Häkkinen A-M, Goto T, Westerbacka J, Sovijärvi A, Halavaara J, Yki-Järvinen H (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87(7):3023–3028CrossRefPubMed

Zurück zum Zitat Soares AF, Paz-Montoya J, Lei H, Moniatte M, Gruetter R (2017) Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice. NMR Biomed. doi:10.1002/nbm.3761 Soares AF, Paz-Montoya J, Lei H, Moniatte M, Gruetter R (2017) Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice. NMR Biomed. doi:10.​1002/​nbm.​3761

Zurück zum Zitat Steneberg P, Sykaras AG, Backlund F, Straseviciene J, Söderström I, Edlund H (2015) Hyperinsulinemia enhances hepatic expression of the fatty acid transporter Cd36 and provokes hepatosteatosis and hepatic insulin resistance. J Biol Chem 290(31):19034–19043CrossRefPubMedPubMedCentral Steneberg P, Sykaras AG, Backlund F, Straseviciene J, Söderström I, Edlund H (2015) Hyperinsulinemia enhances hepatic expression of the fatty acid transporter Cd36 and provokes hepatosteatosis and hepatic insulin resistance. J Biol Chem 290(31):19034–19043CrossRefPubMedPubMedCentral

Zurück zum Zitat Liu T-W, Heden TD, Morris EM, Fritsche KL, Vieira-Potter VJ, Thyfault JP (2015) High-fat diet alters serum fatty acid profiles in obesity prone rats: implications for in vitro studies. Lipids 50(10):997–1008CrossRefPubMedPubMedCentral Liu T-W, Heden TD, Morris EM, Fritsche KL, Vieira-Potter VJ, Thyfault JP (2015) High-fat diet alters serum fatty acid profiles in obesity prone rats: implications for in vitro studies. Lipids 50(10):997–1008CrossRefPubMedPubMedCentral

Zurück zum Zitat Raclot T (2003) Selective mobilization of fatty acids from adipose tissue triacylglycerols. Prog Lipid Res 42(4):257–288CrossRefPubMed Raclot T (2003) Selective mobilization of fatty acids from adipose tissue triacylglycerols. Prog Lipid Res 42(4):257–288CrossRefPubMed

Zurück zum Zitat Viljanen APM, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, Järvisalo M, Parkkola R, Rönnemaa T, Guiducci L, Lehtimäki T, Raitakari OT, Mari A, Nuutila P (2009) Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab 94(1):50–55CrossRefPubMed Viljanen APM, Iozzo P, Borra R, Kankaanpää M, Karmi A, Lautamäki R, Järvisalo M, Parkkola R, Rönnemaa T, Guiducci L, Lehtimäki T, Raitakari OT, Mari A, Nuutila P (2009) Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab 94(1):50–55CrossRefPubMed

Zurück zum Zitat Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair M, Peters JM, Busik J, Olson LK, Jump DB (2006) Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 47(9):2028–2041CrossRefPubMedPubMedCentral Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair M, Peters JM, Busik J, Olson LK, Jump DB (2006) Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 47(9):2028–2041CrossRefPubMedPubMedCentral

Zurück zum Zitat Weiss K, Mihály J, Liebisch G, Marosvölgyi T, Garcia AL, Schmitz G, Decsi T, Rühl R (2013) Effect of high versus low doses of fat and vitamin A dietary supplementation on fatty acid composition of phospholipids in mice. Genes Nutr 9(1):368CrossRefPubMedPubMedCentral Weiss K, Mihály J, Liebisch G, Marosvölgyi T, Garcia AL, Schmitz G, Decsi T, Rühl R (2013) Effect of high versus low doses of fat and vitamin A dietary supplementation on fatty acid composition of phospholipids in mice. Genes Nutr 9(1):368CrossRefPubMedPubMedCentral

Zurück zum Zitat Ntambi JM (1992) Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 267(15):10925–10930PubMed Ntambi JM (1992) Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 267(15):10925–10930PubMed

Zurück zum Zitat Duarte JAG, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC (2014) A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice. J Lipid Res 55(12):2541–2553CrossRefPubMedPubMedCentral Duarte JAG, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC (2014) A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice. J Lipid Res 55(12):2541–2553CrossRefPubMedPubMedCentral

Zurück zum Zitat Oosterveer MH, van Dijk TH, Tietge UJF, Boer T, Havinga R, Stellaard F, Groen AK, Kuipers F, Reijngoud D-J (2009) High fat feeding induces hepatic fatty acid elongation in mice. PLoS ONE 4(6):e6066CrossRefPubMedPubMedCentral Oosterveer MH, van Dijk TH, Tietge UJF, Boer T, Havinga R, Stellaard F, Groen AK, Kuipers F, Reijngoud D-J (2009) High fat feeding induces hepatic fatty acid elongation in mice. PLoS ONE 4(6):e6066CrossRefPubMedPubMedCentral

Zurück zum Zitat Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FPW, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G (2015) Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. J Hepatol 63(2):437–445CrossRefPubMedPubMedCentral Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FPW, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G (2015) Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. J Hepatol 63(2):437–445CrossRefPubMedPubMedCentral

Zurück zum Zitat Bidar AW, Ploj K, Lelliott C, Nelander K, Winzell MS, Böttcher G, Oscarsson J, Storlien L, Hockings PD (2012) In vivo imaging of lipid storage and regression in diet-induced obesity during nutrition manipulation. Am J Physiol Endocrinol Metab 303(11):E1287–E1295CrossRefPubMed Bidar AW, Ploj K, Lelliott C, Nelander K, Winzell MS, Böttcher G, Oscarsson J, Storlien L, Hockings PD (2012) In vivo imaging of lipid storage and regression in diet-induced obesity during nutrition manipulation. Am J Physiol Endocrinol Metab 303(11):E1287–E1295CrossRefPubMed

Zurück zum Zitat Foster MT, Softic S, Caldwell J, Kohli R, deKloet AD, Seeley RJ (2013) Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it. Physiol Rep 1(2):e00015CrossRefPubMedPubMedCentral Foster MT, Softic S, Caldwell J, Kohli R, deKloet AD, Seeley RJ (2013) Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it. Physiol Rep 1(2):e00015CrossRefPubMedPubMedCentral

Zurück zum Zitat Luu YK, Lublinsky S, Ozcivici E, Capilla E, Pessin JE, Rubin CT, Judex S (2009) In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys 31(1):34–41CrossRefPubMed Luu YK, Lublinsky S, Ozcivici E, Capilla E, Pessin JE, Rubin CT, Judex S (2009) In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys 31(1):34–41CrossRefPubMed

Zurück zum Zitat Valsesia A, Saris WH, Astrup A, Hager J, Masoodi M (2016) Distinct lipid profiles predict improved glycemic control in obese, nondiabetic patients after a low-caloric diet intervention: the diet, obesity and genes randomized trial. Am J Clin Nutr 104(3):566–575CrossRefPubMed Valsesia A, Saris WH, Astrup A, Hager J, Masoodi M (2016) Distinct lipid profiles predict improved glycemic control in obese, nondiabetic patients after a low-caloric diet intervention: the diet, obesity and genes randomized trial. Am J Clin Nutr 104(3):566–575CrossRefPubMed