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Erschienen in:

01.04.2012

Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus

verfasst von: Chantal J. M. Broers, Reinoud J. B. J. Gemke, Michel E. Weijerman, Koen F. van der Sluijs, A. Marceline van Furth

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2012

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Abstract

Purpose

Children with down syndrome (DS) have an increased susceptibility to infections, due to altered humoral and/or cellular immunity. The aim of this study was to determine the cytokine production in whole blood of children with DS upon stimulation with live influenza A virus.

Methods

Whole blood of 61 children with DS and 57 of their healthy siblings was stimulated with 2.5 × 10⁴ TCID50/ml influenza A virus during 6, 24, and 48 h. TNF-α, IL-1β, IL-6, IL-8, IL-10, IL-12p70, IFN-α, IFN-γ concentrations, and viral load were measured at all time points.

Results

At most of the time points, TNF-α, IL-1β, IL-6, and IL-8 concentrations were significantly higher in children with DS following stimulation with live influenza A virus. IFN-α and IFN-γ levels were also significantly higher in the DS group. Viral clearance, however, was equal in both groups.

Conclusions

Children with DS have an altered immune response to influenza A virus. The production of higher levels of pro-inflammatory cytokines may be responsible for a more severe clinical course of viral disease in these children.

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Titel: Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus
verfasst von: Chantal J. M. Broers
Reinoud J. B. J. Gemke
Michel E. Weijerman
Koen F. van der Sluijs
A. Marceline van Furth
Publikationsdatum: 01.04.2012
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2012
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-011-9625-4

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Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus

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Purpose

Methods

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Conclusions

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