Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. This observation has received little attention and there have been no attempts to provide a causal explanation.
At baseline in an international comparative study on obesity, 289 participants aged 25–44 were recruited from communities in the US, the Seychelles, Ghana and South Africa and had REE measured with indirect calorimetry. All participants were thought to be free of major illness.
In multivariate regression models, both systolic and diastolic blood pressure were positively associated with REE (p < 0.01), while body mass index and fat mass were negatively correlated with systolic blood pressure (p < 0.01, and p < 0.05 respectively), but not diastolic blood pressure.
These data confirm previous reports and suggest that a common physiologic abnormality links REE and blood pressure. Elevated catecholamines, a putative metabolic characteristic of obesity, is a possible candidate to explain this association. The direct role of excess adipose tissue is open to question.
DeLany JP, Jakicic JM, Lowery JB, Hames KC, Kelley DE, Goodpaster BH. African American women exhibit similar adherence to intervention but lose less weight due to lower energy requirements. Int J Obes. 2014;38(9):1147–52. CrossRef
Ravussin E, Bogardus C. A brief overview of human energy metabolism and its relationship to essential obesity. Am J Clin Nutri. 1992;55(1 Suppl):242S–5S.
Astrup A, Simonsen L, Bulow J, Madsen J, Christensen NJ. Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle. Am J Phys. 1989;257(3 Pt 1):E340–5.
Webber J, Macdonald IA. Metabolic actions of catecholamines in man. Bailliere Clin Endocrinol Metab. 1993;7(2):393–413. CrossRef
Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WG, Boyce V, Howard BV, Bogardus C: Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med. 1988;318(8):467–72.
Weinsier RL, Nelson KM, Hensrud DD, Darnell BE, Hunter GR, Schutz Y. Metabolic predictors of obesity. Contribution of resting energy expenditure, thermic effect of food, and fuel utilization to four-year weight gain of post-obese and never-obese women. J Clin Invest. 1995;95(3):980–5. PubMedPubMedCentralCrossRef
Sriram N, Hunter GR, Fisher G, Brock DW. Resting energy expenditure and systolic blood pressure relationships in women across 4.5 years. J Clin Hypertens (Greenwich). 2014;16(3):172–6. CrossRef
Dyer AR, Elliott P. The INTERSALT study: relations of body mass index to blood pressure. INTERSALT co-operative research group. J Hum Hypertens. 1989;3(5):299–308. PubMed
Allen A, Stamler J, Stamler R, Gosch F, Cooper R, Trevisan M, Persky V. Observational and interventional experiences on dietary sodium intake and blood pressure. New York: Academic Press; 1981.
Dugas LR, Forrester TE, Plange-Rhule J, Bovet P, Lambert EV, Durazo-Arvizu RA, Cao G, Cooper RS, Khatib R, Tonino L, et al. Cardiovascular risk status of afro-origin populations across the spectrum of economic development: findings from the modeling the epidemiologic transition study. BMC Public Health. 2017;17(1):438. PubMedPubMedCentralCrossRef
Dugas LR, Kliethermes S, Plange-Rhule J, Tong L, Bovet P, Forrester TE, Lambert EV, Schoeller DA, Durazo-Arvizu RA, Shoham DA, et al. Accelerometer-measured physical activity is not associated with two-year weight change in African-origin adults from five diverse populations. PeerJ. 2017;5:e2902. PubMedPubMedCentralCrossRef
Luke A, Bovet P, Plange-Rhule J, Forrester TE, Lambert EV, Schoeller DA, Dugas LR, Durazo-Arvizu RA, Shoham DA, Cao G, et al. A mixed ecologic-cohort comparison of physical activity & weight among young adults from five populations of African origin. BMC Public Health. 2014;14:397. PubMedPubMedCentralCrossRef
Luke A, Bovet P, Forrester TE, Lambert EV, Plange-Rhule J, Schoeller DA, Dugas LR, Durazo-Arvizu RA, Shoham D, Cooper RS, et al. Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk. BMC Public Health. 2012;11:927. CrossRef
Luke A, Bovet P, Forrester T, Lambert EV, Plange-Rhule J, Schoeller DA, Dugas LR, Durazo-Arvizu RA, Shoham D, Cooper RS, et al. Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk. BMC Public Health. 2011;11:927.
Cooper R, Puras A, Tracy J, Kaufman J, Asuzu M, Ordunez P, Mufunda J, Sparks H. Evaluation of an electronic blood pressure device for epidemiological studies. Blood Press Monit. 1997;2(1):35–40. PubMed
Luke A, Bovet P, Forrester TE, Lambert EV, Plange-Rhule J, Dugas LR, Durazo-Arvizu RA, Kroff J, Richie WN, Schoeller DA. Prediction of fat-free mass using bioelectrical impedance analysis in young adults from five populations of African origin. Eur J Clin Nutr. 2013;67(9):956–60. PubMedPubMedCentralCrossRef
Schoeller DA, van Santen E, Peterson DW, Dietz W, Jaspan J, Klein PD. Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr. 1980;33(12):2686–93. PubMed
Assessment of Body Composition and Total Energy Expenditure in Humans Using Stable Isotope Techniques. IAEA Human Health Series 3. Vienna, Austria; 2009. http://www-pub.iaea.org/MTCD/Publications/PDF/Pub1370_web.pdf.
Wang Z, Deurenberg P, Wang W, Pietrobelli A, Baumgartner RN, Heymsfield SB. Hydration of fat-free body mass: new physiological modeling approach. Am J Phys. 1999;276(6 Pt 1):E995–E1003.
Moore FD, Olesen KH, McMurrey JD, et al. The body cell mass and its surrounding environment. Philadelphia: Saunders; 1963.
Luke A, Durazo-Arvizu R, Adeyemo A, et al. Resting metabolic rate is positively associated with weight change in a lean population. Obes Res. 2004;12:A229.
United Nations Development Programme. Human development report 2011: sustainability and equity: a better future for all. New York: Palgrave Macmillan; 2012.
Bitvise Tunnelier, Version 4.40 [ http://www.bitvise.com/tunnelier].
Seravalle G, Grassi G. Sympathetic Nervous System, Hypertension, Obesity and Metabolic Syndrome. High Blood Press Cardiovasc Prev. 2016;23(3):175–9.
Barbero U, D'Ascenzo F, Nijhoff F, Moretti C, Biondi-Zoccai G, Mennuni M, Capodanno D, Lococo M, Lipinski MJ, Gaita F. Assessing risk in patients with stable coronary disease: when should we intensify care and follow-up? Results from a meta-analysis of observational studies of the COURAGE and FAME era. Scientifica (Cairo). 2016;2016:3769152.
Alexander JK. Obesity and the heart. Heart Dis Stroke. 1993;2(4):317–21. PubMed
- Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora
Richard S. Cooper
Estelle V. Lambert
Terrence E. Forrester
Lara R. Dugas
- BioMed Central
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