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Erschienen in: Journal of Natural Medicines 3/2020

31.03.2020 | Original Paper

Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.

verfasst von: Shunya Murakami, Nozomu Hayashi, Teruyo Inomata, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2020

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Abstract

Fungal co-culture is a strategy to induce the production of secondary metabolites by activating cryptic genes. We discovered the production of a new compound, talarodone A (1), along with five known compounds 26 in co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp. isolated from soil collected in Miyazaki Prefecture, Japan. Among them, the productions of penicidones C (2) and D (3) were enhanced 27- and sixfold, respectively, by the co-culture. The structure of 3 should be represented as a γ-pyridol form with the reported chemical shifts, but not as a γ-pyridone form, based on DFT calculation.

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Metadaten
Titel
Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.
verfasst von
Shunya Murakami
Nozomu Hayashi
Teruyo Inomata
Hikaru Kato
Yuki Hitora
Sachiko Tsukamoto
Publikationsdatum
31.03.2020
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 3/2020
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-020-01400-1

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