Erschienen in:
16.04.2018 | Correspondence
Infectious prions do not induce Aβ deposition in an in vivo seeding model
verfasst von:
Jay Rasmussen, Susanne Krasemann, Hermann Altmeppen, Petra Schwarz, Juliane Schelle, Adriano Aguzzi, Markus Glatzel, Mathias Jucker
Erschienen in:
Acta Neuropathologica
|
Ausgabe 6/2018
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Excerpt
An increasing number of studies have suggested that certain cases of iatrogenic Creutzfeldt–Jakob disease (iCJD) that harbor significant β-amyloid (Aβ) pathology are the result of aggregated Aβ transmission to patients during the same procedure that caused prion disease [
2,
4,
7,
8,
11,
13,
17]. The source of iatrogenic contamination has been observed both for human growth hormone infusions and dura mater grafts, arguing against a treatment specific effect. Intriguingly, recent work has also observed suspected Aβ pathology transmission in post-mortem samples that received growth hormone treatments but did not develop CJD [
17]. Yet another study suggested that neurosurgery with Aβ-contaminated tools can transmit Aβ pathology and lead to intracerebral hemorrhage [
12]. These findings have been debated in the context of whether Aβ pathology is truly transmissible and whether Alzheimer’s disease could subsequently develop. …
