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Erschienen in: Gynäkologische Endokrinologie 4/2018

12.07.2018 | Fehlgeburt | CME

Infektiologische und immunologische Aspekte bei Kinderwunsch

verfasst von: PD Dr. med. Ruben-J. Kuon, Volker Daniel, Kilian Vomstein, Maja Weber, Timo Gaiser, Bettina Toth

Erschienen in: Gynäkologische Endokrinologie | Ausgabe 4/2018

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Zusammenfassung

Trotz modernster Verfahren der Reproduktionsmedizin inklusive der Präimplantationsdiagnostik gelingt in manchen Fällen auch bei wiederholtem Transfer eines morphologisch und genetisch unauffälligen Embryos keine Einnistung. Man spricht von rezidivierendem Implantationsversagen (RIF). Darüber hinaus sind etwa 1–3 % aller Paare von wiederkehrenden Spontanaborten (WSA) betroffen. Lediglich bei etwa der Hälfte dieser Paare lässt sich ein ursächlicher Faktor ermitteln. In den letzten Jahren sind infektiologische und immunologische Aspekte in den Fokus der Ursachensuche gerückt. Neben autoimmunologischen Faktoren wie dem Antiphospholipidsyndrom wird insbesondere die Rolle der peripheren und uterinen natürlichen Killerzellen bei der Implantation und dem Abortgeschehen beleuchtet. Neueste Daten weisen zudem auf eine Bedeutung der chronischen Endometritis als Risikofaktor sowohl für RIF als auch für WSA hin. Inwieweit sich die Pathogenese bei RIF und WSA überschneidet, ist unklar.
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Metadaten
Titel
Infektiologische und immunologische Aspekte bei Kinderwunsch
verfasst von
PD Dr. med. Ruben-J. Kuon
Volker Daniel
Kilian Vomstein
Maja Weber
Timo Gaiser
Bettina Toth
Publikationsdatum
12.07.2018
Verlag
Springer Medizin
Schlagwörter
Fehlgeburt
Hysteroskopie
Erschienen in
Gynäkologische Endokrinologie / Ausgabe 4/2018
Print ISSN: 1610-2894
Elektronische ISSN: 1610-2908
DOI
https://doi.org/10.1007/s10304-018-0196-9

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