The online version of this article (doi:10.1186/s12969-017-0147-3) contains supplementary material, which is available to authorized users.
Inflammatory bowel disease can develop in the context of some rheumatic diseases in childhood, including juvenile idiopathic arthritis (JIA). Inflammatory bowel disease (IBD) is frequently associated with other immune-mediated diseases; however, systemic onset JIA (sJIA) has not previously been connected to IBD. Treatment of sJIA has significantly changed in recent years, possibly causing changes in inflammatory patterns. Therefore, data from the German Center for Pediatric and Adolescent Rheumtology from 2010 until 2015 were analyzed by retrospective chart review.
Eighty-two patients with confirmed diagosis of sJIA were found. Of these, three were identified with a diagnosis of IBD confirmed by colonoscopy (two cases of Crohn’s disease, one case of ulcerative colitis) 0.8 – 4.3 years after diagnosis. All three were treated with IL-1 antagonists (anakinra in two cases, canakinumab in one case) and were well controlled for sJIA symptoms at time of diagnosis of IBD
IBD seems to be a rare, but possible complication of sJIA. Treatment with IL-1 antagonists might be a relevant factor for a switch in the clinical phenotype of the underlying inflammatory process.
Additional file 1: Table S1. Supplementary clinical and laboratory data for the patients at time of diagnosis of sJIA. (DOCX 23 kb)12969_2017_147_MOESM1_ESM.docx
Additional file 2: Table S2. Coloscopy results of the 3 patients, translated and summarized from the German original. (DOCX 23 kb)12969_2017_147_MOESM2_ESM.docx
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- Inflammatory bowel disease following anti-interleukin-1-treatment in systemic juvenile idiopathic arthritis
- BioMed Central
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