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Current Oncology Reports

Erschienen in:

01.10.2019 | Breast Cancer (B Overmoyer, Section Editor)

Inflammatory Breast Cancer: a Separate Entity

verfasst von: Jennifer M. Rosenbluth, Beth A. Overmoyer

Erschienen in: Current Oncology Reports | Ausgabe 10/2019

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Abstract

Purpose of Review

Inflammatory breast cancer (IBC) is an uncommon but highly aggressive subtype of breast cancer that contributes significantly to breast cancer–related mortality. In this review, we provide an overview of the clinical and molecular characteristics of IBC, and highlight some areas of need for ongoing research.

Recent Findings

The disease is characterized by florid tumor emboli that obstruct dermal lymphatics, leading to swelling and inflammation of the affected breast. Recent studies have focused on tumor cell intrinsic features, such as signaling through pathways involved in growth and stem-like behavior, as well as extrinsic features, such as the immune system, that can be leveraged to develop new potential therapies.

Summary

Key efforts have led to an increase in awareness of the disease as well as new insights into IBC pathogenesis. However, there is a strong need for new therapies designed specifically for IBC, and many unanswered questions remain.

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Titel: Inflammatory Breast Cancer: a Separate Entity
verfasst von: Jennifer M. Rosenbluth
Beth A. Overmoyer
Publikationsdatum: 01.10.2019
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 10/2019
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-019-0842-y

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