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Breast Cancer Research

Erschienen in:

01.06.2003 | Review

Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model

verfasst von: Kazuo Shirakawa, Hisataka Kobayashi, Jun Sobajima, Daijo Hashimoto, Atsushi Shimizu, Hiro Wakasugi

Erschienen in: Breast Cancer Research | Ausgabe 3/2003

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Abstract

We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis (with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry–angiogenesis junction.

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Titel: Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model
verfasst von: Kazuo Shirakawa
Hisataka Kobayashi
Jun Sobajima
Daijo Hashimoto
Atsushi Shimizu
Hiro Wakasugi
Publikationsdatum: 01.06.2003
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 3/2003
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr585

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Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model

Abstract

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